Heme oxygenase-1 system in organ transplantation1

Bilirubin Is an Antioxidant of Possible Physiological Importance

1987 • 3,406 citations

THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases

1997 • 2,481 citations

Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

2000 • 2,074 citations

Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury.

1996 • 1,116 citations

Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice

2002 • 1,002 citations

Carbon Monoxide Generated by Heme Oxygenase 1 Suppresses Endothelial Cell Apoptosis

2000 • 970 citations

The heme synthesis and degradation pathways: role in oxidant sensitivity

2000 • 779 citations

Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat.

1992 • 691 citations

Expression of heme oxygenase-1 can determine cardiac xenograft survival

1998 • 621 citations

Heme oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblasts.

1994 • 520 citations

Heme oxygenase-1 protects against vascular constriction and proliferation

2001 • 515 citations

Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury

1999 • 489 citations

Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes

1998 • 466 citations

Carbon Monoxide Generated by Heme Oxygenase-1 Suppresses the Rejection of Mouse-to-Rat Cardiac Transplants

2001 • 455 citations

Iron regulates nitric oxide synthase activity by controlling nuclear transcription.

1994 • 413 citations

Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase

2001 • 413 citations

Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis

2001 • 396 citations

Cloned, expressed rat cerebellar nitric oxide synthase contains stoichiometric amounts of heme, which binds carbon monoxide.

1992 • 368 citations

Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia

2001 • 362 citations

Induction of Heme Oxygenase-1 Suppresses Venular Leukocyte Adhesion Elicited by Oxidative Stress

1999 • 356 citations

Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide.

1995 • 355 citations

Gene Therapy Strategy for Long-Term Myocardial Protection Using Adeno-Associated Virus-Mediated Delivery of Heme Oxygenase Gene

2002 • 304 citations

A beneficial role of bile pigments as an endogenous tissue protector: Anti-complement effects of biliverdin and conjugated bilirubin

1993 • 266 citations

Heme Oxygenase-1 Induction in Islet Cells Results in Protection From Apoptosis and Improved In Vivo Function After Transplantation

2001 • 263 citations

Carbon monoxide is a major contributor to the regulation of vascular tone in aortas expressing high levels of haeme oxygenase‐1

1998 • 239 citations

Association of Serum Bilirubin Concentration with Risk of Coronary Artery Disease

2000 • 228 citations

Ex vivoexposure to carbon monoxide prevents hepatic ischemia/reperfusion injury through p38 MAP kinase pathway

2002 • 227 citations

MHC class II molecules, cathepsins, and La/SSB proteins in lacrimal acinar cell endomembranes

1999 • 195 citations

Effect of Superoxide Anions on Red Blood Cell Rheologic Properties

1998 • 183 citations

Heme Oxygenase-1 Overexpression Protects Rat Livers from Ischemia/Reperfusion Injury with Extended Cold Preservation

2001 • 178 citations

Induction of kidney heme oxygenase-1 (HSP32) mRNA and protein by ischemia/reperfusion: possible role of heme as both promotor of tissue damage and regulator of HSP32.

1993 • 177 citations

Heme oxygenase modulates selectin expression in different regional vascular beds

2000 • 158 citations

HEME OXYGENASE-1 OVEREXPRESSION PROTECTS RAT HEARTS FROM COLD ISCHEMIA/REPERFUSION INJURY VIA AN ANTIAPOPTOTIC PATHWAY1

2002 • 158 citations

Heme oxygenase-1 gene transfer inhibits inducible nitric oxide synthase expression and protects genetically fat Zucker rat livers from ischemia-reperfusion injury1

2002 • 153 citations

Carbon monoxide attenuates aeroallergen-induced inflammation in mice

2001 • 147 citations

Adenovirus-mediated transfer of heme oxygenase-1 cDNA attenuates severe lung injury induced by the influenza virus in mice

2001 • 139 citations

Heme Oxygenase 1 Gene Transfer Prevents CD95/Fas Ligand-Mediated Apoptosis and Improves Liver Allograft Survival via Carbon Monoxide Signaling Pathway

2002 • 128 citations

CD154-CD40 T-cell costimulation pathway is required in the mechanism of hepatic ischemia/reperfusion injury, and its blockade facilitates and depends on heme oxygenase-1 mediated cytoprotection

2002 • 122 citations

Protective roles of endogenous carbon monoxide in neointimal development elicited by arterial injury

2000 • 117 citations

Stress protein-induced immunosuppression: inhibition of cellular immune effector functions following overexpression of haem oxygenase (HSP 32)

1998 • 114 citations

The interaction of hemin and bilirubin with the human red cell membrane

1982 • 88 citations

A novel strategy against ischemia and reperfusion injury: cytoprotection with heme oxygenase system

2002 • 87 citations

PHYSIOLOGICAL AND BIOCHEMICAL EFFECTS ON RATS AND MICE EXPOSED TO SMALL CONCENTRATIONS OF CARBON MONOXIDE FOR LONG PERIODS

1970 • 83 citations

Hepatic subcellular metabolism of heme from heme-hemopexin: Incorporation of iron into ferritin

1979 • 74 citations

NITRIC OXIDE PRODUCTION AND NITRIC OXIDE SYNTHASE EXPRESSION IN ACUTE HUMAN RENAL ALLOGRAFT REJECTION1

2000 • 55 citations

Red cell trapping after ischemia and long-term kidney damage. Influence of hematocrit

1990 • 53 citations

GENE TRANSFER OF IMMUNOMODULATORY PEPTIDES CORRELATES WITH HEME OXYGENASE-1 INDUCTION AND ENHANCED ALLOGRAFT SURVIVAL 1

2000 • 44 citations

ALLEVIATION OF GRAFT-VERSUS-HOST DISEASE AFTER CONDITIONING WITH COBALT-PROTOPORPHYRIN, AN INDUCER OF HEME OXYGENASE-1

2000 • 43 citations

PRIOR INDUCTION OF HEAT SHOCK PROTEINS BY A NITRIC OXIDE DONOR ATTENUATES CARDIAC ISCHEMIA/REPERFUSION INJURY IN THE RAT1

2000 • 37 citations

Studies on hepatic injury and antioxidant enzyme activities in rat subcellular organelles following in vivo ischemia and reperfusion.

1997 • 37 citations

Local heat-shock priming-induced improvement in microvascular perfusion in osteomyocutaneous flaps is mediated by heat-shock protein 32

2001 • 36 citations

Effect of recipients' peri‐operative parameters on the outcome of kidney transplantation

1998 • 31 citations

ANTAGONIZING LEUKOTRIENE B4 RECEPTORS DELAYS CARDIAC ALLOGRAFT REJECTION IN MICE

1999 • 29 citations

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1997 • 29 citations

Pretreatment of small bowel isograft donors with cobalt-protoporphyrin decreases preservation injury

1999 • 27 citations

INFLUENCE OF THE PRETRANSPLANT HEMATOCRIT LEVEL ON EARLY GRAFT FUNCTION IN PRIMARY CADAVERIC RENAL TRANSPLANTATION

1993 • 27 citations

Selectin-Mediated Interactions Regulate Cytokine Networks and Macrophage Heme Oxygenase-1 Induction in Cardiac Allograft Recipients

2002 • 26 citations

Carboxyhemaglobin Levels in Methylene Chloride-Exposed Employees

1996 • 21 citations

Retinal pigment epithelial cell-based gene therapy against hemoglobin toxicity.

1998 • 21 citations

Hemopexin Decreases Spontaneous Chemiluminescence of Cold Preserved Liver after Reperfusion

1998 • 16 citations

Overexpression of heme oxygenase-1 protects allogeneic thyroid grafts from rejection in naive mice

2000 • 15 citations

Effects of hepatic ischemia-reperfusion injury on the hepatic mixed function oxidase system in rats.

1990 • 12 citations

De novo protein synthesis induced by donor nutritional depletion ameliorates cold ischemia and reperfusion injury in rat liver

2000 • 11 citations

Endothelial Injury and Trapping of Blood Cells in Human Myocardium Following Coronary Bypass Surgery

1999 • 10 citations

Effect of leukotriene B4 receptor antagonist (ONO4057) on hepatic allografting in rats

2000 • 7 citations

Isovolemic hemodilution and skeletal muscle function during ischemia and reperfusion

1998 • 5 citations