A Significant Role for the Heme Oxygenase-1 Gene in Endothelial Cell Cycle Progression

Bilirubin Is an Antioxidant of Possible Physiological Importance

1987 • 3,406 citations

RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

1996 • 1,955 citations

Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications

1988 • 1,699 citations

Reduced stress defense in heme oxygenase 1-deficient cells

1997 • 1,263 citations

Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency

1999 • 1,237 citations

Carbon Monoxide Generated by Heme Oxygenase 1 Suppresses Endothelial Cell Apoptosis

2000 • 970 citations

Isolation and Characterization of a cDNA from the Rat Brain that Encodes Hemoprotein Heme Oxygenase‐3

1997 • 834 citations

Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage.

1993 • 603 citations

Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy.

1992 • 494 citations

Time course of endothelial dysfunction and myocardial injury during myocardial ischemia and reperfusion in the cat.

1990 • 471 citations

Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia

2001 • 362 citations

Induction of Heme Oxygenase-1 Suppresses Venular Leukocyte Adhesion Elicited by Oxidative Stress

1999 • 356 citations

Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide.

1995 • 355 citations

Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells: protective effect against heme and hemoglobin toxicity.

1995 • 343 citations

Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron.

1991 • 309 citations

Thiol Compounds Interact with Nitric Oxide in Regulating Heme Oxygenase-1 Induction in Endothelial Cells

1997 • 297 citations

Induction of heme oxygenase-1 inhibits the monocyte transmigration induced by mildly oxidized LDL.

1997 • 294 citations

Dithiocarbamates Induce Apoptosis in Thymocytes by Raising the Intracellular Level of Redox-active Copper

1995 • 280 citations

The Biological Significance and Physiological Role of Heme Oxygenase

1996 • 254 citations

Heme Induces the Expression of Adhesion Molecules ICAM-1, VCAM-1, and E Selectin in Vascular Endothelial Cells

1997 • 225 citations

Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2.

1998 • 213 citations

Gene transfer of human heme oxygenase into coronary endothelial cells potentially promotes angiogenesis

1998 • 213 citations

Functional Analysis of cDNAs for Two Types of Human Heme Oxygenase and Evidence for Their Separate Regulation1

1993 • 196 citations

Overexpression of the Heme Oxygenase Gene in Renal Cell Carcinoma

1997 • 187 citations

Human Heme Oxygenase-1 Gene Transfer Lowers Blood Pressure and Promotes Growth in Spontaneously Hypertensive Rats

2001 • 159 citations

Sn-protoporphyrin use in the management of hyperbilirubinemia in term newborns with direct Coombs-positive ABO incompatibility.

1988 • 159 citations

Differential effects of heme oxygenase isoforms on heme mediation of endothelial intracellular adhesion molecule 1 expression.

1999 • 145 citations

Retrovirus-mediated HO gene transfer into endothelial cells protects against oxidant-induced injury

1999 • 126 citations

Induction of heart heme oxygenase-1 (HSP32) by hyperthermia: possible role in stress-mediated elevation of cyclic 3':5'-guanosine monophosphate.

1994 • 124 citations

Preischemic But Not Postischemic Zinc Protoporphyrin Treatment Reduces Infarct Size and Edema Accumulation After Temporary Focal Cerebral Ischemia in Rats

1995 • 112 citations

Heme protein-mediated renal injury: A protective role for 21-aminosteroids in vitro and in vivo

1995 • 107 citations

Exacerbation of Chronic Renovascular Hypertension and Acute Renal Failure in Heme Oxygenase-1–Deficient Mice

2001 • 102 citations

Heme oxygenase isoform-specific expression and distribution in the rat kidney

2001 • 101 citations

Transcriptional regulation of the heme oxygenase 1 gene by pyrrolidine dithiocarbamate

1998 • 96 citations

A Single Dose of Sn-Mesoporphyrin Prevents Development of Severe Hyperbilirubinemia in Glucose-6-Phosphate Dehydrogenase-Deficient Newborns

2001 • 81 citations

Presence of heme oxygenase and NADPH cytochrome P-450 (c) reductase in human corneal epithelium.

1987 • 78 citations

Pyrrolidine dithiocarbamate-induced apoptosis depends on cell type, density, and the presence of Cu²⁺ and Zn²⁺

2000 • 76 citations

Dual role of heme oxygenase in epithelial cell injury: Contrasting effects of short-term and long-term exposure to oxidant stress

1996 • 76 citations

Sensitivity of human tissue heme oxygenase to a new synthetic metalloporphyrin

1989 • 71 citations

Pyrrolidine Dithiocarbamate Induces Bovine Cerebral Endothelial Cell Death by Increasing the Intracellular Zinc Level

1999 • 62 citations

Regulation of human heme oxygenase in endothelial cells by using sense and antisense retroviral constructs

2001 • 55 citations