Retrovirus-mediated HO gene transfer into endothelial cells protects against oxidant-induced injury

Microsomal Heme Oxygenase

1969 • 1,348 citations

Reduced stress defense in heme oxygenase 1-deficient cells

1997 • 1,263 citations

Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury.

1996 • 1,116 citations

Heme oxygenase 1 is required for mammalian iron reutilization

1997 • 998 citations

In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium

1992 • 953 citations

Isolation and Characterization of a cDNA from the Rat Brain that Encodes Hemoprotein Heme Oxygenase‐3

1997 • 834 citations

Heme oxygenase: A novel target for the modulation of inflammatory response

1996 • 784 citations

Hypoxia-inducible Factor-1 Mediates Transcriptional Activation of the Heme Oxygenase-1 Gene in Response to Hypoxia

1997 • 775 citations

Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP.

1995 • 709 citations

Construction and use of a safe and efficient amphotropic packaging cell line

1988 • 637 citations

Induction of heme oxygenase: a general response to oxidant stress in cultured mammalian cells.

1991 • 635 citations

Site-Specific Gene Expression in Vivo by Direct Gene Transfer into the Arterial Wall

1990 • 573 citations

Heme oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblasts.

1994 • 520 citations

Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes

1998 • 466 citations

Construction and use of a safe and efficient amphotropic packaging cell line

1988 • 416 citations

Transcriptional control of rat heme oxygenase by heat shock.

1987 • 415 citations

Heme oxygenase 2: endothelial and neuronal localization and role in endothelium-dependent relaxation.

1996 • 401 citations

The enzymatic catabolism of hemoglobin: stimulation of microsomal heme oxygenase by hemin.

1970 • 396 citations

Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells: protective effect against heme and hemoglobin toxicity.

1995 • 343 citations

Hemoglobin provides protection against lethal endotoxemia in rats: the role of heme oxygenase-1.

1995 • 309 citations

The Biological Significance and Physiological Role of Heme Oxygenase

1996 • 254 citations

Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide

1997 • 235 citations

Functional Analysis of cDNAs for Two Types of Human Heme Oxygenase and Evidence for Their Separate Regulation1

1993 • 196 citations

Human heme oxygenase-2: Characterization and expression of a full-length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal

1992 • 184 citations

Hepatic gene therapy: adenovirus enhancement of receptor-mediated gene delivery and expression in primary hepatocytes.

1993 • 169 citations

Corticosterone Regulates Heme Oxygenase‐2 and NO Synthase Transcription and Protein Expression In Rat Brain

1994 • 148 citations

Heme Oxygenase-mediated Resistance to Oxygen Toxicity in Hamster Fibroblasts

1997 • 135 citations

Characterization of the enzyme

1994 • 134 citations

Regulation of heme oxygenase-2 by glucocorticoids in neonatal rat brain: characterization of a functional glucocorticoid response element

1997 • 125 citations

Preischemic But Not Postischemic Zinc Protoporphyrin Treatment Reduces Infarct Size and Edema Accumulation After Temporary Focal Cerebral Ischemia in Rats

1995 • 112 citations

Direct demonstration of a physiological role for carbon monoxide in olfactory receptor neurons

1995 • 103 citations

Adenovirus-mediated heme oxygenase-1 gene transfer into rabbit ocular tissues.

1995 • 96 citations

Heme oxygenase is a heat shock protein and PEST protein in rat astroglial cells

1992 • 84 citations

Dual role of heme oxygenase in epithelial cell injury: Contrasting effects of short-term and long-term exposure to oxidant stress

1996 • 76 citations

Sensitivity of human tissue heme oxygenase to a new synthetic metalloporphyrin

1989 • 71 citations

Vehicles for gene therapy

1993 • 50 citations

Transient induction of heme oxygenase after cortical stab wound injury

1996 • 46 citations

Activation of nuclear factor kappa B and oncogene expression by 12(R)-hydroxyeicosatrienoic acid, an angiogenic factor in microvessel endothelial cells.

1994 • 40 citations

Zinc Protoporphyrin, Zinc Ion, and Protoporphyrin Reduce Focal Cerebral Ischemia

1996 • 39 citations

The hematopoietic stromal microenvironment promotes retro‐virus‐mediated gene transfer into hematopoietic stem cells

1993 • 31 citations

Adenovirus Mediated Alpha Interferon (IFN‐α) Gene Transfer into CD34⁺Cells and CML Mononuclear Cells

1997 • 25 citations