ALLEVIATION OF GRAFT-VERSUS-HOST DISEASE AFTER CONDITIONING WITH COBALT-PROTOPORPHYRIN, AN INDUCER OF HEME OXYGENASE-1

THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases

1997 • 2,481 citations

Carbon Monoxide: a Putative Neural Messenger

1993 • 1,519 citations

Reduced stress defense in heme oxygenase 1-deficient cells

1997 • 1,263 citations

Heme oxygenase 1 is required for mammalian iron reutilization

1997 • 998 citations

Heme oxygenase: A novel target for the modulation of inflammatory response

1996 • 784 citations

Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase.

1987 • 466 citations

Accommodation of vascularized xenografts: Expression of “protective genes” by donor endothelial cells in a host Th2 cytokine environment

1997 • 428 citations

Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia.

1996 • 348 citations

Cyclic Nucleotide-Gated Ion Channels: An Extended Family With Diverse Functions

1996 • 305 citations

Induction of heme oxygenase in toxic renal injury: A protective role in cisplatin nephrotoxicity in the rat

1995 • 263 citations

Inhibition of Inducible Nitric Oxide Synthase by Peroxisome Proliferator-Activated Receptor Agonists: Correlation with Induction of Heme Oxygenase 1

1998 • 241 citations

Kinetics of Th1 and Th2 cytokine production during the early course of acute and chronic murine graft-versus-host disease. Regulatory role of donor CD8+ T cells.

1995 • 232 citations

CYTOKINE CASCADES IN ACUTE GRAFT-VERSUS-HOST DISEASE1

1997 • 225 citations

Induction of Heme Oxygenase‐1 mRNA and Protein in Neocortex and Cerebral Vessels in Alzheimer's Disease

1995 • 209 citations

Differential cytokine expression in acute and chronic murine graft‐versus‐host‐disease

1993 • 194 citations

Nitric oxide production in host-versus-graft and graft-versus-host reactions in the rat.

1992 • 179 citations

Antibodies to IFN-gamma prevent immunologically mediated intestinal damage in murine graft-versus-host reaction.

1989 • 178 citations

Induction of kidney heme oxygenase-1 (HSP32) mRNA and protein by ischemia/reperfusion: possible role of heme as both promotor of tissue damage and regulator of HSP32.

1993 • 177 citations

Regulation of heme oxygenase-1 gene expression in vascular smooth muscle cells by nitric oxide

1997 • 175 citations

Signalling by cGMP-dependent protein kinases

1996 • 169 citations

Bilirubin inhibits the activation of superoxide-producing NADPH oxidase in a neutrophil cell-free system

1991 • 161 citations

New Developments in the Regulation of Heme Metabolism and Their Implications

1984 • 145 citations

IL-12 stimulates the development of acute graft-versus-host disease in mice that normally would develop chronic, autoimmune graft-versus-host disease.

1994 • 131 citations

Endothelial cell heme oxygenase and ferritin induction in rat lung by hemoglobin in vivo

1995 • 115 citations

Stress protein-induced immunosuppression: inhibition of cellular immune effector functions following overexpression of haem oxygenase (HSP 32)

1998 • 114 citations

IL-12 is a central mediator of acute graft-versus-host disease in mice.

1996 • 109 citations

Computer-assisted rational design of immunosuppressive compounds

1998 • 104 citations

cGMP Signaling through cAMP- and cGMP-Dependent Protein Kinases

1995 • 98 citations

Mode of Inhibitory Action of Bilirubin on Protein Kinase C

1985 • 91 citations

Murine graft-versus-host disease in an F1-hybrid model using IFN-gamma gene knockout donors.

1998 • 85 citations

Renal ischemia/reperfusion up-regulates heme oxygenase-1 (HSP32) expression and increases cGMP in rat heart.

1996 • 73 citations

Heme oxygenase induction with attenuation of experimentally induced corneal inflammation

1997 • 73 citations

Intracellular accumulation of unconjugated bilirubin inhibits phytohemagglutinin-induced proliferation and interleukin-2 production of human lymphocytes

1996 • 63 citations

Characterization and Biological Significance of Immunosuppressive Peptide D2702.75–84(E → V) Binding Protein

1998 • 58 citations

Acute graft-versus-host reaction can be aborted by blockade of costimulatory molecules.

1995 • 46 citations

Unconjugated bilirubin inhibits in vitro major histocompatibility complex-unrestricted cytotoxicity of human lymphocytes

1996 • 40 citations

Evidence for a Cyclic Guanosine Monophosphate—Dependent, Carbon Monoxide—Mediated, Signaling System in the Regulation of TNF-α Production by Human Pulmonary Macrophages

1995 • 32 citations

Modulation of Corneal Heme Oxygenase Expression by Oxidative Stress Agents

1995 • 31 citations

cGMP-inhibited phosphodiesterases (PDE3 gene family)

1996 • 30 citations

FK506 inhibits graft-versus-host disease and bone marrow graft rejection in murine recipients of MHC disparate donor grafts by interfering with mature peripheral T cell expansion post-transplantation.

1994 • 29 citations

Second messenger systems as targets for new therapeutic agents: focus on selective phosphodiesterase inhibitors.

1995 • 28 citations

Immunosuppression By D-Isomers Of Hla Class I Heavy Chain (Amino Acid 75 To 84)-Derived Peptides Is Independent Of Binding To Hsc70

1997 • 23 citations

PREVENTION OF GRAFT-VERSUS-HOST DISEASE BY RS-61443 IN TWO DIFFERENT RODENT MODELS

1993 • 15 citations

Prevention of graft-versus-host disease by RS-61443 in two different rodent models.

1993 • 12 citations

Prevention of acute graft-versus-host disease by treatment with a novel immunosuppressant. Cholera toxin B subunit.

1995 • 9 citations