Poly(ADP‐ribose) and carcinogenesis

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor

2002 • 1,771 citations

(ADP-ribose)n participates in DNA excision repair

1980 • 1,112 citations

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

1997 • 1,034 citations

XRCC1 Is Specifically Associated with Poly(ADP-Ribose) Polymerase and Negatively Regulates Its Activity following DNA Damage

1998 • 900 citations

Poly(ADP-ribose) Polymerase-2 (PARP-2) Is Required for Efficient Base Excision DNA Repair in Association with PARP-1 and XRCC1

2002 • 674 citations

Nicotinamide mononucleotide activation of a new DNA-dependent polyadenylic acid synthesizing nuclear enzyme

1963 • 613 citations

Resistance to endotoxic shock as a consequence of defective NF-kappa B activation in poly (ADP-ribose) polymerase-1 deficient mice

1999 • 569 citations

PARP is important for genomic stability but dispensable in apoptosis

1997 • 556 citations

Novel inhibitors of poly(ADP-ribose) synthetase

1980 • 519 citations

Chromatin Loosening by Poly(ADP)-Ribose Polymerase (PARP) at Drosophila Puff Loci

2003 • 437 citations

The 193-Kd Vault Protein, Vparp, Is a Novel Poly(Adp-Ribose) Polymerase

1999 • 386 citations

Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin

1999 • 368 citations

DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines

1998 • 350 citations

Tumour Production in Glandular Stomach of Rat by N-Methyl-N′-Nitro-N-Nitrosoguanidine

1967 • 343 citations

Involvement of poly(ADP-ribose) polymerase in base excision repair

1999 • 322 citations

Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes

1999 • 292 citations

A Role of Poly (ADP-Ribose) Polymerase in NF- B Transcriptional Activation

1999 • 289 citations

Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes

1999 • 286 citations

Multistep Carcinogenesis: a 1992 Perspective

1992 • 279 citations

The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA.

1990 • 271 citations

NAD⁺ as a metabolic link between DNA damage and cell death

2004 • 261 citations

Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability

1999 • 255 citations

Stimulation of the DNA-dependent Protein Kinase by Poly(ADP-Ribose) Polymerase

1998 • 237 citations

Inhibitors of poly(adenosine diphosphate ribose) polymerase induce sister chromatid exchanges

1980 • 236 citations

The zinc fingers of human poly(ADP-ribose) polymerase are differentially required for the recognition of DNA breaks and nicks and the consequent enzyme activation. Other structures recognize intact DNA.

1990 • 231 citations

Poly (ADP-Ribose) synthetase. Separation and identification of three proteolytic fragments as the substrate-binding domain, the DNA-binding domain, and the automodification domain.

1984 • 226 citations

Poly(adenosine diphosphate ribose)

1973 • 210 citations

Isolation and Characterization of the cDNA Encoding Bovine Poly(ADP-ribose) Glycohydrolase

1997 • 204 citations

Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death

2001 • 203 citations

DNA Polymerase β-mediated Long Patch Base Excision Repair

2001 • 198 citations

Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis

1997 • 173 citations

Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase

1987 • 149 citations

Involvement of Poly(ADP-Ribose) Polymerase 1 and Poly(ADP-Ribosyl)ation in Regulation of Centrosome Function

2003 • 141 citations

Null Mutation of DNA Strand Break-Binding Molecule Poly(ADP-ribose) Polymerase Causes Medulloblastomas in p53−/− Mice

2003 • 140 citations

ATP for the DNA Ligation Step in Base Excision Repair Is Generated from Poly(ADP-ribose)

2000 • 140 citations

Misregulation of gene expression in primary fibroblasts lacking poly(ADP-ribose) polymerase

2000 • 129 citations

DNA Strand Break-Sensing Molecule Poly(ADP-Ribose) Polymerase Cooperates with p53 in Telomere Function, Chromosome Stability, and Tumor Suppression

2001 • 124 citations

DNA ligase IV suppresses medulloblastoma formation.

2002 • 121 citations

Suppression of the poly(ADP-ribose) polymerase activity by DNA-dependent protein kinase in vitro

1999 • 118 citations

Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation.

2002 • 117 citations

An Alternative Splicing Event Which Occurs in Mouse Pachytene Spermatocytes Generates a Form of DNA Ligase III with Distinct Biochemical Properties That May Function in Meiotic Recombination

1997 • 117 citations

Chromosomal aberrations in PARP ^−/− mice: Genome stabilization in immortalized cells by reintroduction of poly(ADP-ribose) polymerase cDNA

1999 • 107 citations

Differential expression of angiogenic and vasodilatory factors by invasive trophoblast giant cells depending on depth of invasion

2003 • 107 citations

Depletion of nuclear poly(ADP-ribose) polymerase by antisense RNA expression: influences on genomic stability, chromatin organization, and carcinogen cytotoxicity.

1994 • 96 citations

Interaction of Oct‐1 and automodification domain of poly(ADP‐ribose) synthetase

1998 • 88 citations

Poly(ADP-ribose) polymerase gene expression status and genomic instability in human breast cancer.

1996 • 88 citations

Naturally-occurring antibodies to poly(ADP-ribose) in patients with systemic lupus erythematosus

1977 • 86 citations

Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout mice to nitrosamine carcinogenicity

2001 • 83 citations

Induction of rat pancreatic B-cell tumors by the combined administration of streptozotocin or alloxan and poly(adenosine diphosphate ribose) synthetase inhibitors.

1985 • 83 citations

Induction of murine teratocarcinoma cell differentiation by suppression of poly(ADP-ribose) synthesis.

1984 • 80 citations

Parp1-deficiency induces differentiation of ES cells into trophoblast derivatives

2003 • 80 citations

Characterization of sPARP-1

2000 • 79 citations

Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient mice

2001 • 76 citations

Specific Inhibition of Poly(ADP-ribose) Glycohydrolase by Adenosine Diphosphate (Hydroxymethyl)pyrrolidinediol

1995 • 74 citations

Poly(ADP-ribose) Polymerase Localizes to the Centrosomes and Chromosomes

2000 • 70 citations

Parp‐1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane

2003 • 60 citations

Requirement for the Expression of Poly(ADP-ribose) Polymerase during the Early Stages of Differentiation of 3T3-L1 Preadipocytes, as Studied by Antisense RNA Induction

1995 • 60 citations

Loss of the MYC gene amplified in human HL-60 cells after treatment with inhibitors of poly(ADP-ribose) polymerase or with dimethyl sulfoxide.

1989 • 58 citations

Enhancement of N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA amplification in a Simian virus 40-transformed Chinese hamster cell line by 3-aminobenzamide.

1987 • 57 citations

Deletion of transfected oncogenes from NIH 3T3 transformants by inhibitors of poly(ADP-ribose) polymerase.

1988 • 52 citations

Involvement of poly(ADP-ribose) metabolism in induction of differentiation of HL-60 promyelocytic leukemia cells

1982 • 50 citations

Preferential Perinuclear Localization of Poly(ADP-ribose) Glycohydrolase

1999 • 49 citations

Role of (ADP-ribose)nCatabolism in DNA Repair

1997 • 49 citations

Syncytiotrophoblastic giant cells in teratocarcinoma-like tumors derived from Parp -disrupted mouse embryonic stem cells

1999 • 48 citations

Isolation and Cloning of Rat Poly(ADP-Ribose) Glycohydrolase: Presence of a Potential Nuclear Export Signal Conserved in Mammalian Orthologs

1999 • 48 citations

Structural analysis of poly(ADP‐ribose) polymerase in higher and lower eukaryotes

1986 • 43 citations

Stimulation of the catalytic activity of poly(ADP‐ribosyl) transferase by transcription factor Yin Yang 1

1999 • 40 citations

Poly(ADP-ribose) polymerase interacts with a novel human ubiquitin conjugating enzyme: hUbc9

1997 • 36 citations

Regulatory mechanisms of poly(ADP-ribose) polymerase.

1999 • 31 citations

Potentiation of carcinogen-induced methotrexate resistance and dihydrofolate reductase gene amplification by inhibitors of poly(adenosine diphosphate-ribose) polymerase.

1990 • 31 citations

Untitled

1999 • 23 citations

Reversion of malignant phenotype by 5-iodo-6-amino-1,2-benzopyrone a non-covalently binding ligand of poly(ADP-ribose) polymerase

1995 • 21 citations

Gene therapy for prostate cancer by targeting poly(ADP-ribose) polymerase.

2002 • 18 citations

Hyperploidy of embryonic fibroblasts derived from <i>Parp-1</i> knockout mouse

2001 • 11 citations

Inhibition of poly(ADP-ribose) glycohydrolase activity by cyclic peptide antibiotics containing piperazic acid residues

2002 • 10 citations

Yield of SCEs and translocations produced by 3 aminobenzamide in cultured Chinese hamster cells

2000 • 7 citations

Antibody to poly(ADP-ribose) is an indicator of obstetric complications in pregnant patients with systemic lupus erythematosus

1989 • 7 citations

Phylogenic distribution of poly(ADP-ribose) glycohydrolase and poly(ADP-ribose)-digesting phosphodiesterase

2000 • 2 citations