Multistep Carcinogenesis: a 1992 Perspective

Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test

1975 • 7,413 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

“Field cancerization” in oral stratified squamous epithelium. Clinical implications of multicentric origin

1953 • 3,421 citations

Dietary Carcinogens and Anticarcinogens

1983 • 3,028 citations

Identification and characterization of the familial adenomatous polyposis coli gene

1991 • 2,806 citations

Identification of FAP Locus Genes from Chromosome 5q21

1991 • 2,358 citations

Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

1991 • 1,890 citations

Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers

1990 • 1,747 citations

Mechanism of activation of a human oncogene

1982 • 1,417 citations

A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

1982 • 1,398 citations

p53: A Frequent Target for Genetic Abnormalities in Lung Cancer

1989 • 1,214 citations

Studies of Japanese migrants. I. Mortality from cancer and other diseases among Japanese in the United States.

1968 • 1,105 citations

Abnormalities in Structure and Expression of the Human Retinoblastoma Gene in SCLC

1988 • 905 citations

Increased cell division as a cause of human cancer.

1990 • 894 citations

Identification of deletion mutations and three new genes at the familial polyposis locus

1991 • 769 citations

Identification of a Gene Located at Chromosome 5q21 that Is Mutated in Colorectal Cancers

1991 • 758 citations

Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change

1982 • 706 citations

Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma

1990 • 660 citations

A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

1991 • 538 citations

Loss of heterozygosity on chromosomes 3, 13, and 17 in small-cell carcinoma and on chromosome 3 in adenocarcinoma of the lung.

1987 • 487 citations

Inhibition of neoplasia by minor dietary constituents.

1983 • 479 citations

Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma

1986 • 399 citations

Tumour Production in Glandular Stomach of Rat by N-Methyl-N′-Nitro-N-Nitrosoguanidine

1967 • 343 citations

Meat, cooking methods and colorectal cancer: A case‐referent study in Stockholm

1991 • 325 citations

Carcinogenicities of heterocyclic amines in cooked food

1991 • 318 citations

Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma.

1990 • 292 citations

Current situation on regulations for mycotoxins. Overview of tolerances and status of standard methods of sampling and analysis

1989 • 285 citations

The isolation and identification of a new mutagen from fried ground beef: 2-amino-l-methyl-6-phenylimidazo[4, 5-b]pyridine (PhIP)

1986 • 283 citations

Mutagens, carcinogens, and tumor promoters in our daily food

1982 • 233 citations

Detection of frequent p53 gene mutations in primary gastric cancer by cell sorting and polymerase chain reaction single-strand conformation polymorphism analysis.

1991 • 230 citations

Carcinogenicity of 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline in Nonhuman Primates: Induction of Tumors in Three Macaques

1990 • 224 citations

The APC gene, responsible for familial adenomatous polyposis, is mutated in human gastric cancer.

1992 • 223 citations

Studies on Environmental Chemical Carcinogenesis in Japan

1986 • 214 citations

Frequent loss of heterozygosity at the DCC locus in gastric cancer.

1992 • 204 citations

Effect of dietary fish oil on azoxymethane-induced colon carcinogenesis in male F344 rats.

1986 • 201 citations

Induction of Lymphoma in CDF₁ Mice by the Food Mutagen, 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine

1989 • 186 citations

Carcinogenic action of 4-nitroquinoline-N-oxide.

1957 • 175 citations

Clonal Origin of Atypical Adenomatous Hyperplasia of the Liver and Clonal Identity With Hepatocellular Carcinoma

1988 • 168 citations

Hepatitis B virus integration site in hepatocellular carcinoma at chromosome 17;18 translocation.

1986 • 155 citations

Mutagenicity of amino-α-carbolines in pyrolysis products of soybean globulin

1978 • 154 citations

Metabolic activation and covalent binding to nucleic acids of carcinogenic heterocyclic amines from cooked foods and amino acid pyrolysates.

1987 • 148 citations

Molecular Biology of the Carcinogen, 4-Nitroquinoline 1-Oxide

1976 • 130 citations

Formation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in a model system by heating creatinine, glycine and glucose

1984 • 116 citations

Aquilide A, a new mutagenic compound isolated from bracken fern (Pteridium aquilinum (L.) Kuhn)

1983 • 113 citations

Reaction of the N²-acetoxy derivative of 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine (PhIP) with 2'-deoxyguanosine and DNA. Synthesis and identification of N²-(2'-deoxyguanosin-8-yl) - PhIP

1992 • 112 citations

Carcinogenic Action of N-Methyl-N′-nitro-N-nitrosoguanidine

1966 • 107 citations

Mutagenicity of pyrrolizidine alkaloids in the Salmonella/mammalian-microsome test

1979 • 103 citations

Cancer of the Gastrointestinal Tract Among Japanese and White Immigrants in Los Angeles County<xref ref-type="fn" rid="FN2">2</xref>

1987 • 98 citations

Influence of creatine, amino acids and water on the formation of the mutagenic heterocyclic amines found in cooked meat

1989 • 96 citations

Carcinogenic Activity of Petasitenine, a New Pyrrolizidine Alkaloid Isolated From Petasites japonicus Maxim2

1977 • 88 citations

Heterogeneity of lung cancer cells with respect to the amplification and rearrangement of myc family oncogenes

1989 • 82 citations

Reaction of N-hydroxylamine and N-acetoxy derivatives of 2-amino-3-methylimidazolo[4,5-f]quinoline with DNA. Synthesis and identification of N-(deoxyguanosin-8-yl)-IQ

1988 • 78 citations

Rat p53 gene mutations in primary Zymbal gland tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline, a food mutagen.

1992 • 78 citations

Amplifications of both c-Ki-ras with a point mutation and c-myc in a primary pancreatic cancer and its metastatic tumors in lymph nodes.

1986 • 76 citations

DNA Modification by 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine in Rats

1989 • 71 citations

Mutagen activation by cDNA‐expressed P₁450, P₃450, and P450a

1989 • 69 citations

Activation of a mutagen, 3-amino-1-methyl-5H-pyrido[4,3-b]indole. Identification of 3-hydroxyamino-1-methyl-5H-pyrido[4,3-b]indole and its reaction with DNA

1980 • 68 citations

Errors in DNA synthesis: A source of spontaneous mutations

1990 • 63 citations

Modification of DNA with potent mutacarcinogenic 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole isolated from a glutamic acid pyrolysate: structure of the modified nucleic acid base and initial chemical event caused by the mutagen

1982 • 61 citations

Adduct Formation at C‐8 of Guanine on in vitro Reaction f the Ultimate Form of 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine with 2′‐Deoxyguanosine and Its Phosphate Esters

1992 • 58 citations

DNA Adducts Formed by 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline in Rat Liver: Dose‐Response on Chronic Administration

1990 • 57 citations

Mutagenicity and in vitro covalent DNA binding of 2-hydroxyamino-3-methylimidazolo [4,5-f]quinoline

1988 • 57 citations

Activation of 2-amino-1-methyl-6-phenyimidazo[4,5-b] pyridine (PhIP) to mutagenic metabolites

1990 • 56 citations

Occurrence of Multiple Primary Cancer at the National Cancer Center Hospital, 1962–1989

1991 • 47 citations

Use of nitrite and hypochlorite treatments in determination of the contributions of IQ-type and non-IQ-type heterocyclic amines to the mutagenicities in crude pyrolyzed materials

1985 • 46 citations

Cancer mortality among japanese residents of the city of säo paulo, Brazil

1990 • 38 citations

Isolation and identification of the food mutagens IQ and MeIQx from a heated model system of creatinine, glycine and fructose

1986 • 36 citations

Mutational activation of c‐HA‐ras gene in squamous cell carcinomas of rat zymbal gland induced by carcinogenic heterocyclic amines

1991 • 32 citations

Proposed Structures for an an amino-dimethylimidazofuropyridine mutagen in cooked meats

1990 • 30 citations

Interstitial chromosomal deletion within 4q11-q13 in a human hepatoma cell line.

1991 • 26 citations

Detection of 2‐Amino‐1‐methyl‐6‐(4‐hydroxyphenyl)imidazo[4,5‐b]pyridine in Broiled Beef

1992 • 24 citations

The effect of the pyrrolizidine alkaloid integerrimine on the chromosomes of mouse bone marrow cells

1990 • 22 citations

The formation of heart DNA adducts in F344 rats following dietary administration of heterocyclic amines

1991 • 21 citations

Detection of a Ha-ras point mutation by polymerase chain reaction-single strand conformation polymorphism analysis in 2-amino-3,4-dimethylimidazo[4,5-f]quinoline-induced mouse forestomach tumors

1992 • 21 citations

Dietary N-3 fatty acids do not affect induction of Ha-ras mutations in mammary glands of NMU-treated rats

1991 • 20 citations

A 50‐Year Projection of Lung Cancer Deaths among Japanese Males and Potential Impact Evaluation of Anti‐smoking Measures and Screening Using a Computerized Simulation Model

1992 • 18 citations

Transactivation by Hepatitis B Virus May Contribute to Hepatocarcinogenesis

1989 • 15 citations

ras oncogene detection in pre-neoplastic lesions: possible applications for diagnosis and prevention.

1992 • 13 citations

Summary of National Nutrition Survery 1980–1984 by Prefecture

1990 • 11 citations

Multiple Primary Cancers in Patients with Initial Laryngeal Cancer

1990 • 10 citations

Long term trends in cancer mortality rates and cumulative rates from 1955 to 1987 in Japan (2).

1989 • 6 citations

Workshop for the Evaluation of Survival Trends for Cancer Patients

1989 • 3 citations