Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation.

Genetic instabilities in human cancers

1998 • 4,165 citations

DNA double-strand breaks: signaling, repair and the cancer connection

2001 • 2,372 citations

Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas

1998 • 1,085 citations

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

1997 • 1,034 citations

The DNA-dependent protein kinase

1999 • 896 citations

Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease.

1995 • 767 citations

The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene

1999 • 738 citations

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

1996 • 657 citations

The oncogenic activation of β-catenin

1999 • 655 citations

Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks

1995 • 600 citations

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

2000 • 575 citations

PARP is important for genomic stability but dispensable in apoptosis

1997 • 556 citations

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

2000 • 546 citations

DNA Ligase IV Deficiency in Mice Leads to Defective Neurogenesis and Embryonic Lethality via the p53 Pathway

2000 • 491 citations

Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death

2001 • 482 citations

Ku86-Deficient Mice Exhibit Severe Combined Immunodeficiency and Defective Processing of V(D)J Recombination Intermediates

1996 • 430 citations

DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes

1999 • 397 citations

Deletion of Ku86 causes early onset of senescence in mice

1999 • 360 citations

DNA double strand break repair and chromosomal translocation: Lessons from animal models

2001 • 323 citations

Nuclear Accumulation of Mutated β-Catenin in Hepatocellular Carcinoma Is Associated with Increased Cell Proliferation

1999 • 297 citations

Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells

2001 • 289 citations

Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes

1999 • 286 citations

Comprehensive allelotyping of human hepatocellular carcinoma

1997 • 285 citations

APC Mutations in Sporadic Medulloblastomas

2000 • 283 citations

V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.

1996 • 280 citations

Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization

1997 • 274 citations

Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability

1999 • 255 citations

Double-strand breaks and tumorigenesis

2001 • 243 citations

Hypersensitivity ofKu80-deficient cell lines and mice to DNA damage: The effects of ionizing radiation on growth, survival, and development

1997 • 183 citations

cDNA sequence, protein structure, and chromosomal location of the human gene for poly(ADP-ribose) polymerase.

1987 • 181 citations

Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis

1997 • 173 citations

Mutations in the p53 and SCID genes cooperate in tumorigenesis.

1996 • 173 citations

Impaired Nonhomologous End-Joining Provokes Soft Tissue Sarcomas Harboring Chromosomal Translocations, Amplifications, and Deletions

2001 • 173 citations

Poly(ADP-ribose) polymerase: a guardian angel protecting the genome and suppressing tumorigenesis

2001 • 161 citations

Analysis of ku80-Mutant Mice and Cells with Deficient Levels of p53

2000 • 159 citations

Frequent down-regulation of E-cadherin by genetic and epigenetic changes in the malignant progression of hepatocellular carcinomas.

2001 • 146 citations

Allelotype analysis of hepatocellular carcinoma

1998 • 133 citations

Close correlation between β-catenin gene alterations and nuclear accumulation of the protein in human hepatocellular carcinomas

1999 • 128 citations

DNA Strand Break-Sensing Molecule Poly(ADP-Ribose) Polymerase Cooperates with p53 in Telomere Function, Chromosome Stability, and Tumor Suppression

2001 • 124 citations

Suppression of the poly(ADP-ribose) polymerase activity by DNA-dependent protein kinase in vitro

1999 • 118 citations

Chromosomal aberrations in PARP ^−/− mice: Genome stabilization in immortalized cells by reintroduction of poly(ADP-ribose) polymerase cDNA

1999 • 107 citations

A Comprehensive Karyotypic Study on Human Hepatocellular Carcinoma by Spectral Karyotyping

2000 • 103 citations

Relative affinities of poly(ADP-ribose) polymerase and DNA-dependent protein kinase for DNA strand interruptions

1999 • 101 citations

Early Embryonic Lethality in PARP-1 AtmDouble-Mutant Mice Suggests a Functional Synergy in Cell Proliferation during Development

2001 • 95 citations

Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout mice to nitrosamine carcinogenicity

2001 • 83 citations

Identification of de novo chromosomal markers and derivatives by spectral karyotyping

1998 • 66 citations

Enhancement of DEN initiation of liver carcinogenesis by inhibitors of NAD⁺ ADP ribosyl transferase in rats

1984 • 44 citations

Male Rats Fed Methyl- and Folate-Deficient Diets with or without Niacin Develop Hepatic Carcinomas Associated with Decreased Tissue NAD Concentrations and Altered Poly(ADP-ribose) Polymerase Activity ,

1997 • 43 citations

Rejoining of DNA Double-Strand Breaks in Ku80-Deficient Mouse Fibroblasts

1999 • 38 citations

Possible involvement of poly ADP-ribosylation in phenobarbital promotion of rat hepatocarcinogenesis

1990 • 21 citations

Hepatocellular Carcinoma: Contemporary Diagnosis, Investigation and Management

2000 • 20 citations

A YAC Contig Encompassing the XRCC5 (Ku80) DNA Repair Gene and Complementation of Defective Cells by YAC Protoplast Fusion

1995 • 14 citations

Role of DNA Break-sensing Molecule Poly(ADP-ribose) Polymerase (PARP) in Cellular Function and Radiation Toxicity

2000 • 10 citations