Podophyllotoxin, steganacin and combretastatin: Natural products that bind at the colchicine site of tubulin

Brine Shrimp: A Convenient General Bioassay for Active Plant Constituents

1982 • 4,669 citations

Medicinal plants and traditional medicine in Africa

1982 • 3,487 citations

The medicinal and poisonous plants of southern and eastern Africa.

1962 • 3,171 citations

Specification of Molecular Chirality

1966 • 1,774 citations

Medicinal plants of East Africa

1976 • 1,625 citations

PROTOCOLS FOR SCREENING CHEMICAL AGENTS AND NATURAL PRODUCTS AGAINST ANIMAL TUMORS AND OTHER BIOLOGICAL SYSTEMS

1972 • 1,130 citations

Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

1989 • 770 citations

Basic Principles of the CIP‐System and Proposals for a Revision

1982 • 569 citations

Opposite end assembly and disassembly of microtubules at steady state in vitro

1978 • 567 citations

Biological activities of lignans

1984 • 552 citations

The role of the cytoskeletal protein, tubulin, in the mode of action and mechanism of drug resistance to benzimidazoles

1988 • 548 citations

Visualization of the dynamic instability of individual microtubules by dark-field microscopy

1986 • 547 citations

Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin

1989 • 407 citations

Taxol-induced polymerization of purified tubulin. Mechanism of action.

1981 • 407 citations

Genetic and biochemical characterization of multidrug resistance

1985 • 405 citations

Properties of colchicine binding protein from chick embryo brain. Interactions with vinca alkaloids and podophyllotoxin

1970 • 391 citations

Differential binding of methyl benzimidazol-2-yl carbamate to fungal tubulin as a mechanism of resistance to this antimitotic agent in mutant strains of Aspergillus nidulans

1977 • 388 citations

Lignans; chemical, biological and clinical properties

1991 • 373 citations

Nucleoside transport in mammalian cells. Inhibition by colchicine

1972 • 323 citations

Isolation, Structure, and Synthesis of Combretastatins A-1 and B-1, Potent New Inhibitors of Microtubule Assembly, Derived from Combretum caffrum

1987 • 312 citations

Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization

1991 • 292 citations

The Biochemical Events of Mitosis. II. The in Vivo and in Vitro Binding of Colchicine in Grasshopper Embryos and Its Possible Relation to Inhibition of Mitosis^*

1967 • 291 citations

The chemical and biological route from podophyllotoxin glucoside to etoposide: ninth Cain memorial Award lecture.

1991 • 279 citations

Interactions of colchicine with tubulin

1991 • 276 citations

Anti-tumor effects of antibody-alkaline phosphatase conjugates in combination with etoposide phosphate.

1988 • 236 citations

Podophyllotoxin as a probe for the colchicine binding site of tubulin.

1977 • 231 citations

Isolation and structure of combretastatin

1982 • 227 citations

Membrane-bound tubulin in brain and thyroid tissue.

1975 • 223 citations

Promotion of Fluorescence upon Binding of Colchicine to Tubulin

1974 • 218 citations

Tubulin subunit carboxyl termini determine polymerization efficiency.

1985 • 216 citations

Tubulin sulfhydryl groups as probes and targets for antimitotic and antimicrotubule agents

1991 • 205 citations

Tumor inhibitors. LXXXX. Steganacin and steganangin, novel antileukemic lignan lactones from Steganotaenia araliacea

1973 • 198 citations

Effect of VP-16-213 on the intracellular degradation of DNA in HeLa cells

1976 • 197 citations

Comparison of cytotoxicity and DNA breakage activity of congeners of podophyllotoxin including VP16-213 and VM26: a quantitative structure-activity relationship

1984 • 188 citations

Effects of podophyllotoxin and VP-16-213 on microtubule assembly in vitro and nucleoside transport in HeLa cells

1976 • 187 citations

The Biological Effects and the Chemical Composition of Podophyllin. A Review

1954 • 181 citations

Resistance to multiple chemotherapeutic agents in human cancer cells

1988 • 161 citations

THE MECHANISM OF ACTION OF COLCHICINE

1973 • 155 citations

A convenient method for the synthesis of 5′-S-alkylthio-5′-deoxyribonucleosides

1975 • 155 citations

Colchicine and its analogues: Recent findings

1988 • 152 citations

Ligans and neolignans

1985 • 148 citations

Medicinal plants of native America

1986 • 147 citations

Interactions of the catharanthus (Vinca) alkaloids with tubulin and microtubules

1991 • 145 citations

Interaction of tubulin with single ring analogs of colchicine

1982 • 143 citations

Effect of antimitotic drugs on tubulin GTPase activity and self-assembly.

1979 • 142 citations

Structure-activity study of the inhibition of microtubule assembly in vitro by podophyllotoxin and its congeners.

1978 • 142 citations

Conformational states of tubulin liganded to colchicine, tropolone methyl ether, and podophyllotoxin

1982 • 137 citations

Differential cytotoxicity of Combretastatins A1 and A4 in two daunorubicin-resistant P388 cell lines

1990 • 135 citations

Tubulin, hybrid dimers, and tubulin S. Stepwise charge reduction and polymerization.

1985 • 128 citations

Downregulation of tumor necrosis factor receptors on macrophages and endothelial cells by microtubule depolymerizing agents.

1990 • 126 citations

Asymmetric synthesis of (-)-steganone. Further application of chiral biaryl syntheses

1987 • 125 citations

Antineoplastic Agents, 122. Constituents of Combretum caffrum

1987 • 124 citations

Asymmetric total synthesis of (-)-podophyllotoxin

1988 • 123 citations

Microtubule assembly and disassembly at alkaline pH

1981 • 121 citations

The biochemistry of compounds with anti-microtubule activity in plant cells

1991 • 119 citations

Characterization of brain microtubule proteins prepared by selective removal of mitochondrial and synaptosomal components.

1979 • 116 citations

The Similarity of the Effect of Podophyllin and Colchicine and Their Use in the Treatment of Condylomata Acuminata

1946 • 114 citations

Conformational analysis of podophyllotoxin and its congeners. Structure-activity relationship in microtubule assembly

1979 • 113 citations

The Antiviral Action of Lignans

1989 • 113 citations

Synthetic studies on lignan lactones: aryl dithiane route to (.+-.)-podorhizol and (.+-.)-isopodophyllotoxone and approaches to the stegane skeleton

1978 • 111 citations

Lignans, neolignans, and related compounds

1987 • 111 citations

Structure-antitubulin activity relationships in steganacin congeners and analogs. Inhibition of tubulin polymerization in vitro by (.+-.)-isodeoxypodophyllotoxin

1980 • 109 citations

The ambient temperature Ullmann reaction and its application to the total synthesis of (.+-.)-steganacin

1980 • 105 citations

Detection and identification ofPodophyllotoxin produced by cell cultures derived from podophyllum hexandrum royle

1989 • 105 citations

Asymmetric total synthesis of natural (-)-and unnatural (+)-steganacin

1984 • 104 citations

Dynamics of microtubules visualized by darkfield microscopy: Treadmilling and dynamic instability

1988 • 101 citations

Regulation of the microtubule steady state in vitro by ATP

1979 • 99 citations

Molecular cloning of a Chinese hamster mitochondrial protein related to the “chaperonin” family of bacterial and plant proteins

1989 • 99 citations

Interaction of some colchicine analogs, vinblastine and podophyllotoxin with rat brain microtubule protein

1973 • 99 citations

Antihepatotoxic Actions of Lignoids fromSchizandra chinensisFruits

1984 • 97 citations

Growth and podophyllotoxin production in callus tissues of Podophyllum peltatum

1982 • 97 citations

Isolation, structure, and synthesis of combretastatin A-2, A-3, and B-2

1987 • 95 citations

Changes in the circular dichroic spectrum of colchicine associated with its binding to tubulin

1981 • 91 citations

An Investigation of the Antiviral Activity of Podophyllum peltatum

1982 • 85 citations

From podophyllotoxin glucoside to etoposide

1989 • 85 citations

Lignans, neolignans, and related compounds

1990 • 84 citations

Chemical constituents of the Combretaceae. Part II. Substituted phenanthrenes and 9,10-dihydrophenanthrenes and a substituted bibenzyl from the heartwood of Combretum molle

1972 • 84 citations

Interactions of combretastatin, a new plant-derived antimitotic agent, with tubulin

1983 • 82 citations

Interaction of tubulin with drugs and alkylating agents. 2. Effects of colchicine, podophyllotoxin, and vinblastine on the alkylation of tubulin

1981 • 82 citations

Antitumor agents. 111. New 4-hydroxylated and 4-halogenated anilino derivatives of 4'-demethylepipodophyllotoxin as potent inhibitors of human DNA topoisomerase II

1990 • 81 citations

Aryltetralin lignans from Linum flavum and Linum capitatum

1990 • 77 citations

A short synthesis of (.+-.)-isostegane

1976 • 77 citations

Tumour-inhibitory aryltetralin lignans in Podophyllum versipelle, Diphylleia cymosa and Diphylleia grayi

1990 • 76 citations

Effects of inhibitors of tubulin polymerization on GTP hydrolysis.

1981 • 75 citations

Mechanisms by which mammalian cells acquire resistance to drugs that affect microtubule assembly

1989 • 75 citations

Antitumor Agents, 107. New Cytotoxic 4-Alkylamino Analogues of 4'-Demethyl-Epipodophyllotoxin as Inhibitors of Human DNA Topoisomerase II

1989 • 75 citations

Mechanism of microtubule depolymerization. Correlation of rapid induced disassembly experiments with a kinetic model for endwise depolymerization.

1980 • 74 citations

Increased podophyllotoxin production in Podophyllum hexandrum cell suspension cultures after feeding coniferyl alcohol as a β-cyclodextrin complex

1990 • 74 citations

Effects of antimitotic agents on tubulin-nucleotide interactions

1991 • 73 citations

Isolation, Structure, Synthesis, and Antimitotic Properties of Combretastatins B-3 and B-4 from Combretum caffrum

1988 • 73 citations

Potential Anticancer Agents II: Antitumor and Cytotoxic Lignans from Linum Album (Linaceae)

1975 • 72 citations

Comprehensive synthetic route to eight diastereomeric Podophyllum lignans

1989 • 71 citations

First asymmetric total synthesis of (+)-steganacin determination of absolute stereochemistry

1980 • 71 citations

Pharmakologische Studien über Podophyllum peltatum

1880 • 69 citations

Matairesinol as precursor of Podophyllum lignans

1991 • 69 citations

Antimitotic and antitubulin activity of the tumor inhibitor steganacin.

1977 • 68 citations

Efficient coupling of α,α-dimethyl amino acid using a new chloro imidazolidium reagent, CIP

1994 • 67 citations

Properties of tubulin in unfertilized sea urchin eggs. Quantitation and characterization by the colchicine-binding reaction.

1976 • 67 citations

Production of tumour-inhibitory lignans in callus cultures of Podophyllum hexandrum

1990 • 66 citations

Colchicine-like effect of diethylstilbestrol (DES) on mammalian cells in vitro

1978 • 66 citations

Components of the root of Anthriscus sylvestris Hoffm. II. Insecticidal activity.

1982 • 65 citations

Chemical constituents of the combretaceae. Part III. Substituted phenanthrenes, 9,10-dihydrophenanthrenes, and bibenzyls from the heartwood of Combretum psidioides

1972 • 65 citations

Role of GTP hydrolysis in microtubule treadmilling and assembly.

1981 • 64 citations

Tumour-inhibitory aryltetralin lignans from Podophyllum pleianthum

1985 • 64 citations

Diethylstilbestrol induces metaphase arrest and inhibits microtubule assembly

1985 • 64 citations

Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions

1992 • 63 citations

Total synthesis of (+-)-steganacin

1976 • 62 citations

Effect of colchicine binding on the reversible dissociation of the tubulin dimer

1982 • 61 citations

Current status of podophyllotoxin for the treatment of genital warts.

1990 • 60 citations

Biosynthetic relationship of aryltetralin lactone lignans to dibenzylbutyrolactone lignans

1986 • 60 citations

Direct photoaffinity labeling of tubulin with colchicine.

1991 • 59 citations

On the Podophyllotoxins of Root Cultures ofLinum flavum

1988 • 59 citations

Diethylstilboestrol: the binding and effects of diethylstilboestrol upon the polymerisation and depolymerisation of purified microtubule protein in vitro

1985 • 59 citations

Nonenolizable podophyllotoxin derivatives

1977 • 58 citations

Biosynthesis of Podophyllum lignans—II. Interconversions of aryltetralin lignans in Podophyllum hexandrum

1984 • 58 citations

Formation of β-Peltatin-A Methyl Ether and Coniferin by Root Cultures of Linum flavum

1986 • 57 citations

Cytotoxic lignans from Podophyllum, and the nomenclature of aryltetralin lignans

1981 • 57 citations

Antineoplastic agents. 113. Synthesis of natural (-)-combretastatin

1985 • 54 citations

Podophyllum‐ Lignane: Struktur und Absolutkonfiguration von Podorhizol‐β‐<scp>D</scp>‐glucosid ( = Lignan F). 19. Mitt. über mitosehemmende Naturstoffe [1]

1967 • 54 citations

A fluorescence stopped flow study of the competition and displacement kinetics of podophyllotoxin and the colchicine analog 2-methoxy-5-(2′,3′,4′-trimethoxyphenyl) tropone on tubulin.

1987 • 54 citations

Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids

1990 • 54 citations

Maytansine inhibits nucleotide binding at the exchangeable site of tubulin

1985 • 53 citations

Asymmetric total synthesis of the antileukaemic lignan precursor (-)steganone and revision of its absolute configuration

1980 • 53 citations

The Cytological Effects of Podophyllin

1947 • 53 citations

Biosynthesis of podophyllum lignans—i. cinnamic acid precursors of podophyllotoxin in podophyllum hexandrum

1984 • 53 citations

Antineoplastic Drugs in 1990

1990 • 52 citations

Phenolic and terpenoid heartwood constituents of Libocedrus yateensis

1979 • 52 citations

Interaction of phomopsin A and related compounds with purified sheep brain tubulin

1987 • 51 citations

An investigation of the involvement of cytoskeletal structures and secretion in gliding motility of the marine diatom, Amphora coffeaeformis

1985 • 51 citations

Resistance to antimitotic agents as genetic probes of microtubule structure and function

1991 • 50 citations

Cardiostimulatory and antiarrhythmic activity of tubulin-binding agents.

1992 • 50 citations

The interaction of colchicine and some related alkaloids with rat brain tubulin.

1977 • 50 citations

The importance of the phenyl‐tropolone ‘aS’ configuration in colchicine's binding to tubulin

1988 • 48 citations

A microtubule assembly/disassembly model based on drug effects and depolymerization kinetics after rapid dilution.

1979 • 48 citations

The Podophyllotoxin—Picropodophyllin Equilibrium^1,2

1966 • 48 citations

Podophyllotoxin related lignans in plants and cell cultures ofLinum flavum

1991 • 48 citations

Synthesis of the antileukemic agent (.+-.)-steganone using a stereoconvergent biaryl coupling reaction

1985 • 48 citations

Total synthesis of the antileukaemic lignan (±)-steganacin

1977 • 48 citations

Lignans from Juniperus sabina

1990 • 47 citations

Purification, characterization, and assembly properties of tubulin from unfertilized eggs of the sea urchin Strongylocentrotus purpuratus

1983 • 46 citations

Isolation, Purification, and Cytotoxicity of 5-Methoxypodophyllotoxin, a Lignan from a Root Culture of Linum flavum

1992 • 46 citations

In vivo antitumor activity of 6-benzyl-1,3-benzodioxole derivatives against the P388, L1210, B16, and M5076 murine models

1987 • 46 citations

Studies directed towards the asymmetric total synthesis of antileukemic lignan lactones. Synthesis of optically pure key intermediate and its utility

1979 • 45 citations

Stereoselective reactions. XVII. Absolute structure-cytotoxic activity relationships of steganacin congeners and analogs

1991 • 45 citations

Synthesis and antitumor activity of podophyllotoxin aza-analogues

1989 • 45 citations

Podophyllotoxin analogs: effects on DNA topoisomerase II, tubulin polymerization, human tumor KB cells, and their VP-16-resistant variants.

1989 • 45 citations

The effect of Podophyllotoxin on Microtubule Dynamics

1989 • 45 citations

Total synthesis of (±) podophyllotoxin

1987 • 44 citations

VP16-213 and podophyllotoxin

1982 • 44 citations

Photoaffinity labeling of tubulin with (2-nitro-4-azidophenyl)deacetylcolchicine: direct evidence for two colchicine binding sites

1989 • 44 citations

Analysis of the colchicine‐binding site of β‐tubulin

1992 • 43 citations

The binding of Isocolchicine to Tubulin

1989 • 43 citations

The ligand- and microtubule assembly-induced GTPase activity of purified calf brain tubulin

1981 • 43 citations

Plant Anticancer Agents. X. Lignans From Juniperus phoenicea

1980 • 42 citations

Podophyllotoxin-resistant mutants of Chinese hamster ovary cells. Alteration in a microtubule-associated protein.

1982 • 42 citations

Comparison of uptake and binding of two epipodophyllotoxin glucopyranosides, 4'-demethyl epipodophyllotoxin thenylidene-beta-D-glucoside and 4'-demethyl epipodophyllotoxin ethylidene-beta-D-glucoside, in the L1210 leukemia cell.

1978 • 42 citations

Biosynthesis of the lignans α- and β-peltatin

1986 • 42 citations

Factors which disorganize microtubules or microfilaments increase the frequency of cell transformation by polyoma virus

1980 • 42 citations

Antitumor agents. 124. New 4.beta.-substituted aniline derivatives of 6,7-O,O-demethylene-4'-O-demethylpodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II

1992 • 41 citations

Mitochondria, molecular chaperone proteins and the in vivo assembly of microtubules

1990 • 41 citations

Comparison of the neurotoxic effects of colchicine, the vinca alkaloids, and other microtubule poisons

1989 • 41 citations

aS,7S‐absolute configuration of natural (−)‐colchicine and allocongeners

1990 • 40 citations

The Chemistry of Podophyllum

1958 • 40 citations

Podophyllotoxin for condylomata acuminata eradication. Clinical and experimental comparative studies on Podophyllum lignans, colchicine and 5-fluorouracil.

1981 • 39 citations

Stereoselective reactions. V. Design of the asymmetric synthesis of lignan lactones. Synthesis of optically active podorhizon and deoxypodorhizon by 1,3-asymmetric induction.

1982 • 39 citations

Effect of 4 beta-arylamino derivatives of 4'-O-demethylepipodophyllotoxin on human DNA topoisomerase II, tubulin polymerization, KB cells, and their resistant variants.

1991 • 39 citations

Antitumor agents. 100. Inhibition of human DNA topoisomerase II by cytotoxic ether and ester derivatives of podophyllotoxin and .alpha.-peltatin

1989 • 39 citations

Aggregation and calcium-induced fusion of phosphatidylcholine vesicle-tubulin complexes.

1982 • 39 citations

Antitumor agents. 123. Synthesis and human DNA topoisomerase II inhibitory activity of 2'-chloro derivatives of etoposide and 4.beta.-(arylamino)-4'-O-demethylpodophyllotoxins

1992 • 39 citations

Podophyllotoxin-resistant mutants of Chinese hamster ovary cells: cross-resistance studies with various microtubule inhibitors and podophyllotoxin analogues.

1983 • 39 citations

Cell growth inhibitory dihydrophenanthrene and phenanthrene constituents of the african tree Combretum caffrum

1988 • 39 citations

Synthesis of 2-azapodophyllotoxin

1989 • 38 citations

Analysis of the inhibitory effects of VP-16-213 (etoposide) and podophyllotoxin on thymidine transport and metabolism in Ehrlich ascites tumor cells in vitro.

1984 • 38 citations

Species-Specific Differences in Toxicity of Antimitotic Agents Toward Cultured Mammalian Cells&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;

1985 • 38 citations

Preparation of 2-substituted podophyllotoxin derivatives

1987 • 37 citations

Antineoplastic agents. 166. Isolation, structure, and synthesis of combretastatin C-1

1989 • 37 citations

Thermodynamics of reversible monomer-dimer association of tubulin

1991 • 37 citations

Microtubule Assembly and Function in Chlamydomonas : Inhibition of Growth and Flagellar Regeneration by Antitubulins and Other Drugs and Isolation of Resistant Mutants

1974 • 36 citations

Antineoplastic Drugs in 1990

1990 • 35 citations

The structure of yatein. Determination of the positions, and configurations of benzyl groups in lignans of the 2,3-dibenzylbutyrolactone type

1982 • 34 citations

Antitumor Agents, 99. Synthetic Ring C Aromatized Podophyllotoxin Analogues as Potential Inhibitors of Human DNA Topoisomerase II

1988 • 34 citations

PODOPHYLLUM DERIVATIVES (CPH 82) COMPARED WITH PLACEBO IN THE TREATMENT OF RHEUMATOID ARTHRITIS

1989 • 34 citations

Synthesis of (–)-steganone

1982 • 34 citations

Steganacin: An inhibitor of HeLa cell growth and microtubule assembly

1978 • 33 citations

Polymerization of tubulin in the presence of colchicine or podophyllotoxin

1979 • 33 citations

The biological activities of podophyllotoxin compounds.

1986 • 33 citations

Cornigerine, a potent antimitotic colchicum alkaloid of unusual structure

1988 • 32 citations

Teniposide (VM-26)- and etoposide (VP-16-213)-induced augmentation of methotrexate transport and polyglutamylation in Ehrlich ascites tumor cells in vitro.

1982 • 32 citations

Tubulin-dependent hydrolysis of guanosine triphosphate as a screening test to identify new antitubulin compounds with potential as antimitotic agents: application to carbamates of aromatic amines.

1989 • 32 citations

Studies on the constituents of the seeds of Hernandia ovigerd L.. VI. Isolation and structural determination of three lignans.

1987 • 32 citations

Antitumor Agents. I. DNA Topoisomerase II Inhibitory Activity and the Structural Relationship of Podophyllotoxin Derivatives as Antitumor Agents.

1992 • 32 citations

A total synthesis of (±) steganacin via the modified Ullmann reaction

1978 • 31 citations

Effect of Gomisin A (TJN-101) on the arachidonic acid cascade in macrophages.

1990 • 31 citations

Methylenedioxy-benzopyran analogs of podophyllotoxin, a new synthetic class of antimitotic agents that inhibit tubulin polymerization

1988 • 31 citations

Outer doublet tubulin reassembly: evidence for opposite end assembly-disassembly at steady state and a disassembly end equilibrium

1979 • 31 citations

Stereoselective reactions. VIII. Stereochemical requirement for the benzylic oxidation of lignan lactone. A highly selective synthesis of the antitumor lignan lactone steganacin by the oxidation of stegane.

1985 • 30 citations

Design, synthesis, and antitumor activity of steganacin aza-analogues

1989 • 30 citations

A New Podophyllotoxin-Type Lignan from Dysosma versipellis var. tomentosa

1991 • 30 citations

Mitochondrial binding of a protein affected in mutants resistant to the microtubule inhibitor podophyllotoxin.

1987 • 29 citations

Microtubules, mitochondria, and molecular chaperones: a new hypothesis for in vivo assembly of microtubules

1990 • 29 citations

Mitochondrial matrix localization of a protein altered in mutants resistant to the microtubule inhibitor podophyllotoxin.

1987 • 29 citations

Lack of cross resistance to benomyl and thiabendazole in some strains of Aspergillus nidulans

1974 • 29 citations

Inhibition of 1-beta-D-arabinofuranosylcytosine transport and net accumulation by teniposide and etoposide in Ehrlich ascites cells and human leukemic blasts.

1985 • 28 citations

Interactions of Vinblastine and Maytansine with Tubulina

1986 • 28 citations

A proposal for a modification of the Cahn, Ingold and Prelog classification of chirality

1990 • 28 citations

Comparison of 1,2-dihydropyrido[3,4-b]pyrazines (1-deaza-7,8-dihydropteridines) with several other inhibitors of mitosis.

1987 • 27 citations

Quantitative structure-activity relationship analysis of combretastatins: a class of novel antimitotic agents.

1991 • 27 citations

E-ring desoxy analogs of etoposide

1989 • 27 citations

Effect of alkaline pH on taxol-microtubule interactions.

1991 • 27 citations

Partitioning of teniposide into membranes and the role of lipid composition

1990 • 27 citations

Antitumor Agents, 130. Novel 4β-Arylamino Derivatives of 3',4'-Didemethoxy-3',4'-dioxo-4-deoxypodophyllotoxin as Potent Inhibitors of Human DNA Topoisomerase II

1992 • 26 citations

Crystal structure and absolute configuration of 2′-bromopodophyllotoxin–0.5 ethyl acetate

1973 • 26 citations

Structure-function studies with derivatives of 6-benzyl-1,3-benzodioxole, a new class of synthetic compounds which inhibit tubulin polymerization and mitosis.

1985 • 26 citations

Effects of anti-microtubule drugs onin vitro polymerization of tubulin from mung bean

1990 • 25 citations

A catalytic dehydrogenation route to azomethine imines.

1990 • 25 citations

Effects of microtubule inhibitors on etoposide accumulation and DNA damage in human K562 cells in vitro.

1987 • 25 citations

3,3',5'-Tri-O-Methylpiceatannol and 4,3',5'-Tri-O-Methylpiceatannol: Impróvements over Piceatannol in Bioactivity

1987 • 25 citations

L'araliangine, nouveau lignane bisbenzocyclooctadienolactonique de Steganotaenia araliacea, Hochst.

1983 • 24 citations

The effects of colchicine analogues on the reaction of tubulin with iodo[14C]acetamide and N,N'-ethylenebis(iodoacetamide).

1985 • 24 citations

Quantitative turbidimetric assay for potency evaluation of colchicine-like drugs

1975 • 24 citations

Stereoselective reactions. X. Total synthesis of optically pure antitumor lignan, burseran.

1985 • 23 citations

Zinc-induced self-assembly of goat brain tubulin: Some novel aspects

1982 • 23 citations

Studies on the constituents of the seeds of Hernandia ovigera L. III. Structures of two new lignans.

1982 • 23 citations

α-(−)-Peltatin, an antiviral constituent of Amanoa aff. oblongifolia

1988 • 23 citations

CHEMIE UND WIRKUNGSMECHANISMUS VON PODOPHYLLIN–DERIVATEN

1972 • 23 citations

Characterization of the in vitro reassembly of tubulin derived from stable Strongylocentrotus purpuratus outer doublet microtubules

1979 • 22 citations

Lignans from polar extracts ofJuniperus thurifera

1992 • 22 citations

Synthesis and antitumor activity of structural analogs of the epipodophyllotoxins

1991 • 22 citations

Isolement du prestegane B à partir de hochst., premier lignane bis-(-hydroxy-benzyl)-butanolide d'origine végétale. - Isolement et synthèse en une étape du diméthylmatairésinol-

1984 • 22 citations

Neoisostegane, a new bisbenzocyclooctadiene lignan lactone from Steganotaeniaaraliacea hochst.

1983 • 22 citations

Thermal Chemistry of Podophyllotoxin in Ethanol and a Comparison of the Cytostatic Activity of the Thermolysis Products

1986 • 22 citations

Microtubule‐associated proteins from antarctic fishes

1990 • 22 citations

Inhibition of sodium urate-induced rat hindpaw edema by colchicine derivatives: correlation with antimitotic activity.

1972 • 21 citations

A new total synthesis of (±) steganone

1981 • 21 citations

Lignans and related phenols. Part XII. Application of nuclear magnetic double resonance to the aryltetrahydronaphthalene class

1972 • 21 citations

Conversion of deoxypodophyllotoxin to podophyllotoxin-related compounds by microbes.

1989 • 21 citations

Chemistry of colchine

1991 • 21 citations

Isolation and Characterization of Cytotoxic Principles from Hyptis verticillata Jacq

1971 • 21 citations

Immunological detection of microtubule poison-induced conformational changes in tubulin.

1983 • 21 citations

Biotransformation of Podophyllum lignans in cell suspension cultures of Forsythia intermedia

1991 • 21 citations

A short synthesis of (±)-steganone and (±)-steganacin

1984 • 20 citations

Neoisostegane, a new bisbenzocyclooctadienolactonic lignan fromSteganotaenia araliacea, hochst.Tetrahedron Lett., 24, 197, (1983).

1983 • 20 citations

High-performance liquid chromatography of aryltet-rahydronaphthalene lignans

1983 • 20 citations

Stereoselective reactions. VII. Synthesis of racemic and optically pure stegane, isostegane, picrostegane, and isopicrostegane via highly selective isomerization.

1985 • 20 citations

Synthesis of podophyllum lignans via an isolable o-quinonoid pyrone

1987 • 20 citations

Neoisostegane, a New Bisbenzocyclooctadiene Lignan Lactone from Steganotaenia araliacea

1984 • 19 citations

Syntheses of All Four Possible Diastereomers of Etoposide and Its Aminoglycosidic Analogues via Optical Resolution of (±) -Podophyllotoxin by Glycosidation with D- and L-Sugars

1987 • 18 citations

Tumor Inhibitors XIX

1967 • 18 citations

Tubulin characterization during embryogenesis of Ascaris suum

1980 • 18 citations

2. Natural products in cancer treatment from bench to the clinic

1991 • 18 citations

Podophyllin

1985 • 18 citations

Morphological Changes in Rat Glioma Cells caused by Adenosine Cyclic 3', 5'-Monophosphate

1978 • 18 citations

The biological actions of deoxypodophyllotoxin (anthricin). I. Physiological activities and conformational analysis of deoxypodophyllotoxin.

1985 • 18 citations

Colchicine binding in the rat tapeworm, Hymenolepis diminuta

1981 • 18 citations

Podophyllotoxin derivatives. 3. The remaining diastereo C-4 alcohols and ketone of the L series

1977 • 18 citations

Bioactive heterocyclic analogs of the antitumor drug, podophyllotoxin

1988 • 17 citations

Étude des Hernandiacées, IX. Lignanes de Deux Hernandia mélanésiens

1984 • 17 citations

Isolation of Podophyllotoxin from Callitrus drummondii

1963 • 17 citations

Correlation of tubulin-binding and antitumor activities of podophyllotoxin analogs.

1978 • 16 citations

Differential radiolabeling of opposite microtubule ends: Methodology, equilibrium exchange-flux analysis, and drug poisoning

1983 • 16 citations

Antitumor agent from Juniperus bermudiana (Pinaceae): Deoxypodophyllotoxin

1977 • 16 citations

Membrane ordering effects of the anticancer agent VM-26

1986 • 15 citations

Incorporation of radioactive tubulin into microtubules at steady state. Experimental and theoretical analysis of the effect of podophyllotoxin.

1981 • 15 citations

Role of microtubules and axolinin in membrane excitation of the squid giant axon

1985 • 15 citations

Modification of the pendant ring of podophyllotoxin

1982 • 15 citations

Studies with Plant Cell Cultures of Podophyllum peltatum L. I. Production of Podophyllotoxin, Deoxypodophyllotoxin, Podophyllotoxone, and 4'-Demethylpodophyllotoxin

1991 • 14 citations

A new route to the bis-benzocyclooctadiene lignan skeleton: Total syntheses of (±) picrostegane, (±) isopicrostegane and (±) isostegane

1978 • 14 citations

Purified podophyllotoxin (CPH-86) inhibits lymphocyte proliferation but augments macrophage proliferation

1987 • 14 citations

Response of Solitary Psoriatic Plaques to Experimental Application of Podophyllotoxin

1986 • 14 citations

Cytotoxic and Tumor Inhibitory Agent from Polygala macradenia Gray (Polygalaceae): 4′-Demethyldeoxypodophyllotoxin

1977 • 14 citations

Studies on the Constituents of the Seeds of Hernandia ovigera L.

1979 • 14 citations

Epimerization and hydrolysis of etoposide analogues in aqueous solution.

1989 • 14 citations

Biomimetic synthesis of podophyllum lignans.

1984 • 13 citations

Synthesis of (±)-podorhizone via intermediate α-hydroxyalkylation of a β-benzyl γ-butyrolactone

1978 • 13 citations

Podophyllotoxin poisoning of microtubules at steady-state: effect of substoichiometric and superstoichiometric concentrations of drug

1982 • 13 citations

Copolymerization of tubulin-colchicine complex and unliganded tubulin in a nonmicrotubular polymer

1983 • 12 citations

Mechanisms of insecticidal action of deoxypodophyllotoxin (anthricin). I. Distribution of deoxypodophyllotoxin in tissues of the 5th instar larvae of silkworm, Bombyx mori LINNE.

1983 • 12 citations

Stereoselective reactions. XII Synthesis of antitumor-active steganacin analogs, picrosteganol and epipicrosteganol, by selective isomerization.

1986 • 12 citations

Studies on the Constituents of the Seeds of Hernandia ovigera L. IX. Identification of Two Dibenzylbutyrolactone-Type Lignans and an Attempt of Conversion into Phenyltetralin-Type Lignan.

1991 • 12 citations

Lignans and related phenols. Part 16. The biogenesis of podophyllotoxin

1981 • 12 citations

Dynamic nuclear magnetic resonance and empirical force field studies of podophyllotoxin

1983 • 11 citations

Mechanism of action of antimitotic drugs: A new hypothesis based on the role of cellular calcium

1989 • 11 citations

New diastereomers of podophyllotoxin. Related hydroxy acids

1975 • 11 citations

Prestegane A, from Steganotaenia araliacea Hochst,: The First Natural Dibenzylbutanolide Lignan with a meta-Phenol - a short synthesis of cis and trans (±) Arctigenin -

1983 • 11 citations

Cyclic AMP-independent stimulation of steroidogenesis in Y-1 adrenal tumor cells by antimitotic agents

1986 • 11 citations

Podophyllotoxin and VP-16-213: a review of their divergent mechanisms of action

1984 • 10 citations

5'-Methoxyyatein and 5'-Methoxypodorhizol New Lignans Isolated from Hernandia cordigera Viell

1985 • 10 citations

Properties of Purified Colchicine-Binding Protein from a Cultured Carrot Cell Extract

1985 • 10 citations

Novel isomerization of dibenzocyclooctadiene lignan lactone —first synthesis of (±)-stegane—

1979 • 10 citations

Teniposide-induced changes in the physical properties of phosphatidylcholine liposomes

1986 • 10 citations

Novel inhibitors of RNA synthesis.

1974 • 10 citations

Lack of inhibition of carrot colchicine binding activity by podophyllotoxin

1984 • 10 citations

Promotion of Tubulin Assembly by Carboxyterminal Charge Reduction

1986 • 9 citations

Synthesis of analogues of 4-deoxypodophyllotoxin

1987 • 9 citations

CPH-86, A Highly Purified Podophyllotoxin, Efficiently Suppresses in Vivo and in Vitro Immune Responses

1985 • 9 citations

The effectiveness of Hernandia spp. (Hernandiaceae) in traditional Samoan medicine and according to scientific analyses

1991 • 9 citations

Colchicine binding in the free-living nematode Caenorhabditis elegans

1989 • 9 citations

Effects of synthetic estrogens, (R,R)-(+)-, (S,S)-(−)-, dl- and meso-hexestrol stereoisomers on microtubule assembly

1990 • 9 citations

N,N′-Ethylene-bis(iodoacetamide) as a probe for structural and functional characteristics of brine shrimp, squid, and bovine tubulins

1985 • 9 citations

Chapter 9 Measurement of Steady-State Tubulin Flux

1982 • 9 citations

Etude des Hernandiacées VI (1): Lignanes et Alcaloïdes de Hernandia guianensis

1984 • 9 citations

α-and β-Peltatin from Eriope macrostachya

1987 • 9 citations

Effects on Bone Marrow Cells of Oral Treatment with Podophyllotoxin Derivatives in Rheumatoid Arthritis

1985 • 9 citations

INDIAN PODOPHYLLUM: IS IT PODOPHYLLUM EMODI OR PODOPHYLLUM HEXANDRUM?

1979 • 9 citations

Colchicine photosensitizes covalent tubulin dimerization

1992 • 8 citations

Interaction of some estrogenic drugs with tubulin. Formation of twisted ribbon structures.

1987 • 8 citations

Cytotoxic Agents of Thujopsis dolabrata (L. fil.) SIEB. et ZUCC.

1972 • 8 citations

ChemInform Abstract: STRUCTURE‐ANTITUBULIN ACTIVITY RELATIONSHIPS IN STEGANACIN CONGENERS AND ANALOGS. INHIBITION OF TUBULIN POLYMERIZATION IN VITRO BY (.+‐.)‐ISODEOXYPODOPHYLLOTOXIN

1980 • 8 citations

Morpholino derivatives of benzyl-benzodioxole, a study of structural requirements for drug interactions at the colchicine/podophyllotoxin binding site of tubulin

1986 • 8 citations

Liver–protective Principle of Thujopsis dolabrata Leaves¹

1979 • 7 citations

Liver-protective actions of desoxypodophyllotoxin and its analogs.

1982 • 7 citations

4′-Demethylepipodophyllotoxin-β-D-Glucoside: A New Podophyllotoxin Derivative With VM-26-Like and VP-16-213-Like Activities&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;

1984 • 7 citations

Study on conformations-biological activities relationships for podophyllotoxin analogues based on crystal structure of deoxypodophyllotoxin (anthricin).

1988 • 6 citations

Possible treadmilling in zinc(II)-induced sheet polymers of bovine brain microtubule protein

1983 • 6 citations

Preparation, Etude Stereochimique et Evaluation de l'Activite Antileucemique de Derives Glucosidiques du (-)-Steganol

1985 • 6 citations

Glycosylated podophyllotoxin congeners: loss of microtubule inhibition and permission of invasion in vitro.

1982 • 6 citations

Isolation, Identification, and Kinetics of Production of Formononetin in Cell Suspension Cultures ofGlycyrrhiza glabra

1990 • 6 citations

Inclusion complexes with podophyllotoxin, structural characterization and chiral recognition

1990 • 5 citations

Expression of c-myc proto-oncogene during podophyllotoxin induced IW32 erythroleukemia cell differentiation

1991 • 5 citations

Effects of the lipophilic anticancer drug teniposide (VM-26) on membrane transport

1990 • 5 citations

Studies on Lignan Lactone Antitumor Agents. V. 1-O-(Aminoethyl) Ether of 4′-O-Demethyl-1-epipodophyllotoxin

1988 • 5 citations

Enhanced expression of Epstein-Barr virus early antigens by antitubulin agents in a latently infected human lymphoblastoid cell line

1985 • 5 citations

Toxicity of microtubular drugs to leukemic lymphocytes

1981 • 5 citations

Synthesis of (±) Combretastatin

1983 • 5 citations

Tubulin binding of conformationally restricted bis-aryl compounds

1991 • 4 citations

Podophyllotoxin analogues: synthesis and computer modelling investigation of structure-activity relationships.

1987 • 4 citations

Podophyllum-Lignane: Struktur und Absolutkonfiguration von Podorhizol-β-D-glucosid.

1967 • 4 citations

Preparation of Glucosidic Derivatives of Steganol

1985 • 4 citations

Stereoselective reactions. XVIII. Synthesis and cytotoxicity of the demethyl derivatives of steganes.

1990 • 4 citations

Effects of mitosis inhibitors on respiration and fast axonal transport in frog sciatic nerves.

1981 • 4 citations

Epipodophyllotoxins: new laboratory and clinical findings.

1989 • 4 citations

Synthesis and biological activities of the C-4 esters of 4'-demethylepipodophyllotoxin.

1987 • 4 citations

Lignans: Chemical, biological and clinical properties

1991 • 3 citations

[Application of anti-p-105 monoclonal antibody to analysis of mode of action of antitumor agents].

1991 • 3 citations

8α-Hydroxyisopicrostegane

1980 • 2 citations

Podophyllotoxin derivatives.

1990 • 2 citations

Protective action of desoxypodophyllotoxin on D-galactosamine-induced liver lesion in rats.

1982 • 2 citations

Uptake and partitioning of epipodophyllotoxins in Ehrlich cells and liposomes

1987 • 2 citations

BIOCHEMICAL GENETICS OF COLCEMID SENSITIVITY11This work was supported in part by National Science Foundation grant GB38431 and National Institutes of Health grant PHS RR-07085–12.

1978 • 1 citations

ChemInform Abstract: TOTAL SYNTHESIS OF THE ANTILEUKEMIC LIGNAN (.+‐.)‐STEGANACIN

1977 • 1 citations

Increased Podophyllotoxin Production inPodophyllum hexandrumCell Suspension Cultures after Feeding Coniferyl Alcohol as a β-Cyclodextrin Complex

1990 • 1 citations

Effects of the anticancer agent VM-26 on hexose uptake in Ehrlich cells.

1989 • 1 citations