Maytansine inhibits nucleotide binding at the exchangeable site of tubulin

Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase.

1977 • 1,579 citations

Colchicine-binding protein of mammalian brain and its relation to microtubules

1968 • 1,140 citations

Tumor inhibitors. LXXIII. Maytansine, a novel antileukemic ansa macrolide from Maytenus ovatus

1972 • 406 citations

Antimitotic Activity of the Potent Tumor Inhibitor Maytansine

1975 • 326 citations

Definition of three classes of binding sites in isolated microtubule crystals

1972 • 249 citations

Separation of active tubulin and microtubule-associated proteins by ultracentrifugation and isolation of a component causing the formation of microtubule bundles

1984 • 224 citations

Glutamate-induced polymerization of tubulin: Characteristics of the reaction and application to the large-scale purification of tubulin

1981 • 181 citations

Effect of antimitotic drugs on tubulin GTPase activity and self-assembly.

1979 • 142 citations

Binding of maytansine to rat brain tubulin

1976 • 123 citations

Guanine Nucleotide Associated with the Protein of the Outer Fibers of Flagella and Cilia

1967 • 103 citations

Maytansine binding to the vinblastine sites of tubulin

1977 • 99 citations

Interactions of combretastatin, a new plant-derived antimitotic agent, with tubulin

1983 • 82 citations

Effects of inhibitors of tubulin polymerization on GTP hydrolysis.

1981 • 75 citations

Initial studies on the cytotoxic action of maytansine, a novel ansa macrolide

1975 • 61 citations

Guanosine 5'-O-(3-thiotriphosphate), a potent nucleotide inhibitor of microtubule assembly.

1984 • 59 citations

Different effects of tubulin ligands on the intrachain cross-linking of beta 1-tubulin.

1984 • 58 citations

Contrasting effects of maytansine and vinblastine on the alkylation of tubulin sulfhydryls

1981 • 51 citations

Deoxyguanosine nucleotide analogs: potent stimulators of microtubule nucleation with reduced affinity for the exchangeable nucleotide site of tubulin

1984 • 38 citations

Nucleotides Bound to Brain Tubulin and Reconstituted Microtubules

1974 • 31 citations

Structure-function studies with derivatives of 6-benzyl-1,3-benzodioxole, a new class of synthetic compounds which inhibit tubulin polymerization and mitosis.

1985 • 26 citations

Interactions of a new antimitotic agent, NSC-181928, with purified tubulin

1982 • 17 citations