The matrix metalloproteinases and their natural inhibitors: prospects for treating degenerative tissue diseases

Matrix metalloproteinases and their inhibitors in connective tissue remodeling

1991 • 3,309 citations

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

Zinc coordination, function, and structure of zinc enzymes and other proteins

1990 • 1,731 citations

Metalloproteinases and their inhibitors in matrix remodeling

1990 • 1,627 citations

Rheumatoid Arthritis

1990 • 1,565 citations

Proteoglycans as modulators of growth factor activities

1991 • 1,338 citations

Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.

1987 • 1,243 citations

The plasminogen activator/plasmin system.

1991 • 1,196 citations

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

1990 • 1,140 citations

SV40-transformed Human Lung Fibroblasts Secrete a 92-kDa Type IV Collagenase Which Is Identical to That Secreted by Normal Human Macrophages

1989 • 1,122 citations

H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.

1988 • 1,050 citations

Tissue Inhibitor of Metalloproteinase (TIMP-2)

1989 • 899 citations

Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9.

1992 • 620 citations

Human 92- and 72-kilodalton type IV collagenases are elastases.

1991 • 550 citations

In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases.

1989 • 462 citations

Antisense RNA-Induced Reduction in Murine TIMP Levels Confers Oncogenicity on Swiss 3T3 Cells

1989 • 459 citations

Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan. A quantitative comparison of the activities of 95 kDa and 72 kDa gelatinases, stromelysins-1 and -2 and punctuated metalloproteinase (PUMP)

1991 • 454 citations

Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin)

1990 • 431 citations

Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases.

1990 • 406 citations

Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate

1990 • 381 citations

Independent expression and cellular processing of Mr 72,000 type IV collagenase and interstitial collagenase in human tumorigenic cell lines.

1990 • 379 citations

The Activation of Human Type IV Collagenase Proenzyme

1989 • 347 citations

The N-terminal domain of tissue inhibitor of metalloproteinases retains metalloproteinase inhibitory activity

1991 • 324 citations

The role of the C-terminal domain in collagenase and stromelysin specificity.

1992 • 311 citations

Proteinase inhibitors

1996 • 275 citations

The C-terminal domain of 72 kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates interactions with tissue inhibitors of metalloproteinases

1992 • 268 citations

Detection of Stromelysin and Collagenase in Synovial Fluid From Patients with Rheumatoid Arthritis and Posttraumatic Knee Injury

1992 • 261 citations

Sites of stromelysin cleavage in collagen types II, IX, X, and XI of cartilage.

1991 • 260 citations

The Role of Plasmhogen Activators in the Regulation of Connective Tissue Metalloproteinasesa

1992 • 243 citations

Inhibition of Collagenolytic Activity and Metastasis of Tumor Cells by a Recombinant Human Tissue Inhibitor of Metalloproteinases

1990 • 233 citations

Preferential inhibition of 72- and 92-kDa gelatinases by tissue inhibitor of metalloproteinases-2

1991 • 227 citations

Fragments of human fibroblast collagenase. Purification and characterization

1989 • 210 citations

Tissue inhibitor of metalloproteinases-2 inhibits the activation of 72 kDa progelatinase by fibroblast membranes

1991 • 201 citations

Tissue inhibitor of metalloproteinase‐2 (TIMP‐2) has erythroid‐potentiating activity

1992 • 200 citations

Regulation of the autoactivation of human 72-kDa progelatinase by tissue inhibitor of metalloproteinases-2

1991 • 198 citations

Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase.

1992 • 197 citations

Purification and Characterization of Two Related but Distinct Metalloproteinase Inhibitors Secreted by Bovine Aortic Endothelial Cells

1989 • 193 citations

The origin of matrix metalloproteinases and their familial relationships

1991 • 182 citations

The activation of human skin fibroblast procollagenase. Sequence identification of the major conversion products.

1987 • 173 citations

Activation of matrix metalloproteinase 3 (stromelysin) and matrix metalloproteinase 2 (‘gelatinase’) by human neutrophil elastase and cathepsin G

1989 • 166 citations

The purification of tissue inhibitor of metalloproteinases-2 from its 72 kDa progelatinase complex. Demonstration of the biochemical similarities of tissue inhibitor of metalloproteinases-2 and tissue inhibitor of metalloproteinases-1

1991 • 164 citations

Substrate specificities and activation mechanisms of matrix metalloproteinases

1991 • 164 citations

Inhibition of autoproteolytic activation of interstitial procollagenase by recombinant metalloproteinase inhibitor MI/TIMP-2

1991 • 156 citations

Gingival fibroblasts degrade type I collagen films when stimulated with tumor necrosis factor and interleukin 1: Evidence that breakdown is mediated by metal loproteinases

1989 • 150 citations

Binding of tissue inhibitor of metalloproteinases 2 to two distinct sites on human 72-kDa gelatinase. Identification of a stabilization site.

1991 • 138 citations

Hormonal regulation of collagenolysis in uterine cervical fibroblasts. Modulation of synthesis of procollagenase, prostromelysin and tissue inhibitor of metalloproteinases (TIMP) by progesterone and oestradiol-17 β

1991 • 135 citations

Inhibition of tumor invasion of smooth muscle cell layers by recombinant human metalloproteinase inhibitor.

1991 • 135 citations

The matrix metalloprotease matrilysin (PUMP) is expressed in developing human mononuclear phagocytes.

1992 • 121 citations

Adenovirus E1A represses protease gene expression and inhibits metastasis of human tumor cells.

1990 • 119 citations

Mutational analysis of the transin (rat stromelysin) autoinhibitor region demonstrates a role for residues surrounding the “cysteine switch”

1991 • 99 citations

Characterization of 58-kilodalton human neutrophil collagenase: comparison with human fibroblast collagenase

1990 • 93 citations

Human fibroblast stromelysin catalytic domain: expression, purification, and characterization of a C-terminally truncated form

1991 • 92 citations

Developmental expression of the endogenous TIMP gene and a TIMP-lacZ fusion gene in transgenic mice.

1990 • 86 citations

An internal cysteine plays a role in the maintenance of the latency of human fibroblast collagenase

1991 • 84 citations

Purification of recombinant human prostromelysin. Studies on heat activation to give high-Mr and low-Mr active forms, and a comparison of recombinant with natural stromelysin activities

1991 • 83 citations

Dissociation of tissue inhibitor of metalloproteinases (TIMP) from enzyme complexes yields fully active inhibitor

1989 • 76 citations

Preferential binding of collagenase to α₂‐macroglobulin in the presence of the tissue inhibitor of metalloproteinases

1986 • 67 citations

On the structure and chromosome location of the 72- and 92-kDa human type IV collagenase genes

1991 • 66 citations

Inactivation of human plasma α₁‐proteinase inhibitor by human PMN leucocyte collagenase

1990 • 65 citations

Proteolytic inactivation of human α₁ antitrypsin by human stromelysin

1991 • 64 citations

Collagenase activity in gingival crevicular fluid of patients with juvenile periodontitis

1991 • 42 citations

Systemic administration of TIMP in the treatment of collagen-induced arthritis in mice

1989 • 42 citations

A domain structure common to hemopexin, vitronectin, interstitial collagenase, and a collagenase homolog.

1987 • 41 citations

Immunolocalization of collagenase and tissue inhibitor of metalloproteinases (TIMP) in hypertrophic scar tissue

1986 • 38 citations

Mercurial activation of human PMN leucocyte type IV procollagenase (gelatinase)

1992 • 31 citations

In vivo effect of human erythroid-potentiating activity on hematopoiesis in mice

1988 • 22 citations

In vivo effect of human erythroid-potentiating activity on hematopoiesis in mice

1988 • 13 citations

Crystallization and preliminary X-ray analysis of porcine synovial collagenase

1989 • 13 citations