Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)–dependent migration and homing in multiple myeloma

Cancer Statistics, 2005

2005 • 5,487 citations

Chemokines — Chemotactic Cytokines That Mediate Inflammation

1998 • 3,660 citations

Chemokines and leukocyte traffic

1998 • 2,755 citations

International Staging System for Multiple Myeloma

2005 • 2,696 citations

Synthesis and Function of 3-Phosphorylated Inositol Lipids

2001 • 1,527 citations

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

2003 • 1,515 citations

A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development

2006 • 1,239 citations

Multiple Myeloma

2004 • 1,219 citations

Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist

2005 • 1,085 citations

The Chemokine SDF-1/CXCL12 Binds to and Signals through the Orphan Receptor RDC1 in T Lymphocytes

2005 • 1,023 citations

In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment

2005 • 860 citations

Trafficking of Normal Stem Cells and Metastasis of Cancer Stem Cells Involve Similar Mechanisms: Pivotal Role of the SDF‐1–CXCR4 Axis

2005 • 758 citations

CXCR4 Regulates Growth of Both Primary and Metastatic Breast Cancer

2004 • 707 citations

CXCR4–SDF-1 Signalling, Locomotion, Chemotaxis and Adhesion

2003 • 697 citations

Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors

2004 • 621 citations

Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

2006 • 431 citations

Chemokines and the Molecular Basis of Cancer Metastasis

2001 • 409 citations

COMPARTMENTALIZED RAS/MAPK SIGNALING

2006 • 396 citations

Antimyeloma activity of heat shock protein-90 inhibition

2005 • 321 citations

Stromal cell-derived factor-1α stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: roles of phosphoinositide-3 kinase and protein kinase C

2000 • 266 citations

Cutting Edge: Profile of Chemokine Receptor Expression on Human Plasma Cells Accounts for Their Efficient Recruitment to Target Tissues

2003 • 263 citations

Chemokine stromal cell-derived factor-1α modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1/fibronectin and VCAM-1

2001 • 252 citations

CXCR4 Physically Associates with the T Cell Receptor to Signal in T Cells

2006 • 249 citations

Circulating plasma cells detected by flow cytometry as a predictor of survival in 302 patients with newly diagnosed multiple myeloma

2005 • 236 citations

Overexpression of G protein-coupled receptors in cancer cells: Involvement in tumor progression

2005 • 230 citations

CD200 is a new prognostic factor in multiple myeloma

2006 • 220 citations

Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors

2001 • 209 citations

Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling.

2003 • 201 citations

In vivo flow cytometer for real-time detection and quantification of circulating cells

2004 • 180 citations

Chemokine receptors that mediate B cell homing to secondary lymphoid tissues are highly expressed in B cell chronic lymphocytic leukemia and non-Hodgkin lymphomas with widespread nodular dissemination

2004 • 174 citations

The biological sequelae of stromal cell-derived factor-1alpha in multiple myeloma.

2002 • 157 citations

Expression and function of chemokine receptors in human multiple myeloma

2003 • 144 citations

Unique SDF-1–induced activation of human precursor-B ALL cells as a result of altered CXCR4 expression and signaling

2003 • 143 citations

Clonal circulating cells are common in plasma cell proliferative disorders: a comparison of monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, and active myeloma

1996 • 107 citations

Fluorescence imaging of multiple myeloma cells in a clinically relevant SCID/NOD in vivo model: biologic and clinical implications.

2003 • 106 citations

Gi-Protein-Dependent Inhibition of IL-12 Production Is Mediated by Activation of the Phosphatidylinositol 3-Kinase-Protein 3 Kinase B/Akt Pathway and JNK

2005 • 105 citations

RNAI AS AN EXPERIMENTAL AND THERAPEUTIC TOOL TO STUDY AND REGULATE PHYSIOLOGICAL AND DISEASE PROCESSES

2004 • 98 citations

Expression of the Chemokine Receptors CXCR4 and CCR7 and Disease Progression in B-Cell Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

2004 • 93 citations

Potential Clinical Applications of the CXCR4 Antagonist Bicyclam AMD3100

2005 • 90 citations

SDF-1 and CXCR4 in normal and malignant hematopoiesis.

2004 • 87 citations

Clinical significance of chemokine receptor (CCR1, CCR2 and CXCR4) expression in human myeloma cells: the association with disease activity and survival.

2006 • 85 citations

Integrin α4β1 involvement in stromal cell-derived factor-1α-promoted myeloma cell transendothelial migration and adhesion: role of cAMP and the actin cytoskeleton in adhesion

2004 • 81 citations

Immature Leukemic CD34 ⁺ CXCR4 ⁺ Cells from CML Patients Have Lower Integrin‐Dependent Migration and Adhesion in Response to the Chemokine SDF‐1

2002 • 81 citations

The involvement of stromal derived factor 1alpha in homing and progression of multiple myeloma in the 5TMM model.

2006 • 72 citations

Defective p38 Mitogen-Activated Protein Kinase Signaling Impairs Chemotaxic but not Proliferative Responses to Stromal-Derived Factor-1α in Acute Lymphoblastic Leukemia

2005 • 68 citations

A genetic lesion that arrests plasma cell homing to the bone marrow

2003 • 65 citations

Role of metalloproteinases MMP‐9 and MT1‐MMP in CXCL12‐promoted myeloma cell invasion across basement membranes

2005 • 63 citations

Mobilization of Myeloma Cells Involves SDF‐1/CXCR4 Signaling and Downregulation of VLA‐4

2004 • 62 citations

Zebrafish G protein γ2 is required for VEGF signaling during angiogenesis

2006 • 54 citations

Gi Proteins Use a Novel βγ- and Ras-independent Pathway to Activate Extracellular Signal-regulated Kinase and Mobilize AP-1 Transcription Factors in Jurkat T Lymphocytes

1999 • 52 citations

Biological effects of stroma-derived factor-1α on normal and CML CD34+ haemopoietic cells

2000 • 42 citations

Stromal cell-derived factor-1α stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: roles of phosphoinositide-3 kinase and protein kinase C

2000 • 20 citations

Deleted Work

1955 • 0 citations