Integrin α4β1 involvement in stromal cell-derived factor-1α-promoted myeloma cell transendothelial migration and adhesion: role of cAMP and the actin cytoskeleton in adhesion
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References (52)
Rho GTPases in cell biology
2002 • 4,662 citations
Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
1995 • 4,387 citations
Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes
1989 • 1,715 citations
The Chemokine SDF-1 Is a Chemoattractant for Human CD34+ Hematopoietic Progenitor Cells and Provides a New Mechanism to Explain the Mobilization of CD34+ Progenitors to Peripheral Blood
1997 • 1,414 citations
G Protein Pathways
2002 • 1,222 citations
Regulation of the Cytoskeleton and Cell Adhesion by the Rho Family GTPases in Mammalian Cells
1999 • 1,015 citations
Cell Adhesion Mediated Drug Resistance (CAM-DR): Role of Integrins and Resistance to Apoptosis in Human Myeloma Cell Lines
1999 • 850 citations
p115 RhoGEF, a GTPase Activating Protein for Gα 12 and Gα 13
1998 • 834 citations
Multiple myeloma: evolving genetic events and host interactions
2002 • 815 citations
Multiple Myeloma: Increasing Evidence for a Multistep Transformation Process
1998 • 761 citations
Matrix-dependent Tiam1/Rac Signaling in Epithelial Cells Promotes Either Cell–Cell Adhesion or Cell Migration and Is Regulated by Phosphatidylinositol 3-Kinase
1998 • 667 citations
A Coordinated Change in Chemokine Responsiveness Guides Plasma Cell Movements
2001 • 620 citations
The chemokine SDF-1 stimulates integrin-mediated arrest of CD34+ cells on vascular endothelium under shear flow
1999 • 569 citations
Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes.
1996 • 560 citations
The chemokine SDF‐lα triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway
1999 • 510 citations
Hematopoietic Progenitor Cell Rolling in Bone Marrow Microvessels: Parallel Contributions by Endothelial Selectins and Vascular Cell Adhesion Molecule 1
1998 • 453 citations
Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion
1993 • 437 citations
Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment
2001 • 419 citations
Vascular cell adhesion molecule-1 expressed by bone marrow stromal cells mediates the binding of hematopoietic progenitor cells
1992 • 417 citations
Multiple Myeloma
1997 • 389 citations
Role of beta 1 and beta 2 integrins in the adhesion of human CD34hi stem cells to bone marrow stroma.
1992 • 388 citations
AKAP Mediated Signal Transduction
2002 • 343 citations
Stromal Cell-derived Factor-1α Associates with Heparan Sulfates through the First β-Strand of the Chemokine
1999 • 322 citations
Serine Phosphorylation Negatively Regulates RhoA in Vivo
2003 • 307 citations
Constitutive expression of E-selectin and vascular cell adhesion molecule-1 on endothelial cells of hematopoietic tissues.
1996 • 306 citations
Vascular cell adhesion molecule-1 expressed by bone marrow stromal cells mediates the binding of hematopoietic progenitor cells
1992 • 300 citations
Active movement of T cells away from a chemokine
2000 • 293 citations
Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins
1997 • 276 citations
cAMP-induced Morphological Changes Are Counteracted by the Activated RhoA Small GTPase and the Rho Kinase ROKα
1998 • 267 citations
Cutting Edge: Profile of Chemokine Receptor Expression on Human Plasma Cells Accounts for Their Efficient Recruitment to Target Tissues
2003 • 263 citations
Chemokine stromal cell-derived factor-1α modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1/fibronectin and VCAM-1
2001 • 252 citations
The rho gene product expressed in E. Coli is a substrate of botulinum ADP-ribosyltransferase C3
1989 • 252 citations
Expression of Functional Chemokine Receptors CXCR3 and CXCR4 on Human Melanoma Cells
2001 • 230 citations
Differentiation of primitive human multipotent hematopoietic progenitors into single lineage clonogenic progenitors is accompanied by alterations in their interaction with fibronectin.
1991 • 224 citations
β-Arrestin Differentially Regulates the Chemokine Receptor CXCR4-mediated Signaling and Receptor Internalization, and This Implicates Multiple Interaction Sites between β-Arrestin and CXCR4
2000 • 214 citations
Adhesion receptors on bone marrow stromal cells: in vivo expression of vascular cell adhesion molecule-1 by reticular cells and sinusoidal endothelium in normal and gamma-irradiated mice
1996 • 208 citations
Elevation of Intracellular cAMP Inhibits RhoA Activation and Integrin-dependent Leukocyte Adhesion Induced by Chemoattractants
1997 • 205 citations
Primary tumor cells of myeloma patients induce interleukin-6 secretion in long-term bone marrow cultures
1994 • 166 citations
Rac Regulates Integrin-Mediated Spreading and Increased Adhesion of T Lymphocytes
1998 • 158 citations
The biological sequelae of stromal cell-derived factor-1alpha in multiple myeloma.
2002 • 157 citations
Fibrinogen induces adhesion, spreading, and microfilament organization of human endothelial cells in vitro.
1987 • 151 citations
Characterization of adhesion molecules on human myeloma cell lines
1992 • 150 citations
Integrin alpha 4 beta 1-mediated melanoma cell adhesion and migration on vascular cell adhesion molecule-1 (VCAM-1) and the alternatively spliced IIICS region of fibronectin.
1994 • 137 citations
T134, a Small-Molecule CXCR4 Inhibitor, Has No Cross-Drug Resistance with AMD3100, a CXCR4 Antagonist with a Different Structure
1999 • 112 citations
Inhibition of Rho Is Required for cAMP-induced Melanoma Cell Differentiation
1998 • 101 citations
Transforming growth factor-β1 down-regulates expression of chemokine stromal cell–derived factor-1: functional consequences in cell migration and adhesion
2003 • 95 citations
In vivo functions of heterotrimeric G-proteins: studies in Gα-deficient mice
2001 • 86 citations
The Chemokine Stromal Cell-Derived Factor-1α Modulates α4β7 Integrin-Mediated Lymphocyte Adhesion to Mucosal Addressin Cell Adhesion Molecule-1 and Fibronectin
2002 • 82 citations
Characterization of VLA‐4‐dependent myeloma cell adhesion to fibronectin and VCAM‐1
1999 • 54 citations
Isolation and characterization of human multiple myeloma cell enriched populations
2000 • 46 citations
Differences in sulfation patterns of heparan sulfate derived from human bone marrow and umbilical vein endothelial cells
2001 • 44 citations
Human bone marrow stromal cell lines from myeloma and rheumatoid arthritis that can support murine pre-B cell growth.
1992 • 38 citations