A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector

1996 • 4,854 citations

A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

2002 • 4,334 citations

RNA interference

2002 • 3,369 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors

2002 • 2,019 citations

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

2002 • 1,526 citations

Gene silencing in mammals by small interfering RNAs

2002 • 1,403 citations

Stable suppression of tumorigenicity by virus-mediated RNA interference

2002 • 1,147 citations

A DNA vector-based RNAi technology to suppress gene expression in mammalian cells

2002 • 1,117 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

RNA interference in adult mice

2002 • 1,060 citations

RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells

2002 • 1,037 citations

Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells

2002 • 965 citations

Effective expression of small interfering RNA in human cells

2002 • 827 citations

U6 promoter–driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells

2002 • 715 citations

Mena, a Relative of VASP and Drosophila Enabled, Is Implicated in the Control of Microfilament Dynamics

1996 • 667 citations

Transgenesis by lentiviral vectors: Lack of gene silencing in mammalian embryonic stem cells and preimplantation embryos

2002 • 529 citations

RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development.

1993 • 393 citations

Gene silencing using micro-RNA designed hairpins

2002 • 310 citations

Lentiviruses as gene transfer agents for delivery to non-dividing cells

1998 • 295 citations

Small Interfering RNA-Mediated Gene Silencing in T Lymphocytes

2002 • 221 citations

RNA interference: the new somatic cell genetics?

2002 • 218 citations

The cytomegalovirus enhancer: a pan-active control element in transgenic mice.

1990 • 211 citations

The Role of Bim, a Proapoptotic BH3‐Only Member of the Bcl‐2 Family, in Cell‐Death Control

2000 • 141 citations

Gene Transfer into Hematopoietic Stem Cells Using Lentiviral Vectors

2002 • 43 citations

Retroviruses as tools to study the immune system

2001 • 36 citations

Deleted Work

1955 • 0 citations