The Chemokine SDF-1/CXCL12 Binds to and Signals through the Orphan Receptor RDC1 in T Lymphocytes

Chemokines

2000 • 3,773 citations

Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion

2005 • 3,543 citations

The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints

2003 • 2,754 citations

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

1998 • 2,496 citations

International union of pharmacology. XXII. Nomenclature for chemokine receptors.

2000 • 1,771 citations

Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4

1999 • 1,714 citations

Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice

1998 • 1,687 citations

Transduction of Receptor Signals by ß-Arrestins

2005 • 1,656 citations

G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4

2002 • 1,335 citations

Chemokines: multiple levels of leukocyte migration control☆

2004 • 849 citations

Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1

1997 • 724 citations

Chemokines Acting via CXCR2 and CXCR4 Control the Release of Neutrophils from the Bone Marrow and Their Return following Senescence

2003 • 701 citations

Tyrosine Sulfation of the Amino Terminus of CCR5 Facilitates HIV-1 Entry

1999 • 688 citations

CD4-Independent Infection by HIV-2 Is Mediated by Fusin/CXCR4

1996 • 669 citations

Selective Amplification And Cloning Of Four New Members Of The G Protein-coupled Receptor Family

1989 • 647 citations

Dancing to the tune of chemokines

2001 • 624 citations

HIV Coreceptor Downregulation as Antiviral Principle: SDF-1α–dependent Internalization of the Chemokine Receptor CXCR4 Contributes to Inhibition of HIV Replication

1997 • 564 citations

Chemokine Requirements for B Cell Entry to Lymph Nodes and Peyer's Patches

2002 • 502 citations

Phorbol Esters and SDF-1 Induce Rapid Endocytosis and Down Modulation of the Chemokine Receptor CXCR4

1997 • 382 citations

Chemokines in the systemic organization of immunity

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Persistent Induction of the Chemokine Receptor CXCR4 by TGF-β1 on Synovial T Cells Contributes to Their Accumulation Within the Rheumatoid Synovium

2000 • 328 citations

WHIM syndromes with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12

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Regulation of Human Chemokine Receptors CXCR4

1997 • 290 citations

Identification of Residues of CXCR4 Critical for Human Immunodeficiency Virus Coreceptor and Chemokine Receptor Activities

2000 • 234 citations

Chemokines, Chemokine Receptors, and Allograft Rejection

2001 • 232 citations

Leukocyte Elastase Negatively Regulates Stromal Cell-derived Factor-1 (SDF-1)/CXCR4 Binding and Functions by Amino-terminal Processing of SDF-1 and CXCR4

2002 • 219 citations

Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands

2002 • 211 citations

AMD3100, a CxCR4 Antagonist, Attenuates Allergic Lung Inflammation and Airway Hyperreactivity

2002 • 205 citations

Vascular Gene Expression in Nonneoplastic and Malignant Brain

2004 • 179 citations

Role of the first and third extracellular domains of CXCR-4 in human immunodeficiency virus coreceptor activity

1997 • 177 citations

Cloning and expression of the human vasoactive intestinal peptide receptor.

1991 • 149 citations

The CXCL12–CXCR4 chemotactic pathway as a target of adjuvant breast cancer therapies

2004 • 130 citations

Novel Cellular Genes Essential for Transformation of Endothelial Cells by Kaposi's Sarcoma–Associated Herpesvirus

2005 • 126 citations

A Putative G Protein-Coupled Receptor, RDC1, Is a Novel Coreceptor for Human and Simian Immunodeficiency Viruses

2000 • 110 citations

Molecular evolution of the human interleukin–8 receptor gene cluster

1992 • 102 citations

Mutation of the DRY Motif Reveals Different Structural Requirements for the CC Chemokine Receptor 5-Mediated Signaling and Receptor Endocytosis

2005 • 100 citations

Effect of Mutations in the Second Extracellular Loop of CXCR4 on Its Utilization by Human and Feline Immunodeficiency Viruses

1999 • 93 citations

Agonistic and antagonistic activities of chemokines

2001 • 91 citations

CXCR4-Tropic HIV-1 Envelope Glycoprotein Functions as a Viral Chemokine in Unstimulated Primary CD4+ T Lymphocytes

2004 • 84 citations

Cloning and chromosomal mapping of an orphan chemokine receptor: mouse RDC1

1998 • 68 citations

Complete nucleotide sequence of a putative G protein coupled receptor: RDC1

1990 • 67 citations

Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor

1991 • 64 citations

A Membrane-proximal Basic Domain and Cysteine Cluster in the C-terminal Tail of CCR5 Constitute a Bipartite Motif Critical for Cell Surface Expression

2001 • 64 citations

A Novel Putative G Protein-Coupled Receptor Highly Expressed in Lung and Testis

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Characterization of the RDC1 gene which encodes the canine omolog of a proposed human VIP receptor Expression does not correlate with an increase in VIP binding sites

1992 • 25 citations

How can human and simian immunodeficiency viruses utilize chemokine receptors as their coreceptors?

2000 • 14 citations