Roles of Gab1 and SHP2 in Paxillin Tyrosine Dephosphorylation and Src Activation in Response to Epidermal Growth Factor

The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

2003 • 1,192 citations

Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

2001 • 751 citations

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1996 • 674 citations

Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation

1987 • 648 citations

Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src

1987 • 567 citations

pp125^FAK-Dependent Tyrosine Phosphorylation of Paxillin Creates a High-Affinity Binding Site for Crk

1995 • 534 citations

Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases

2000 • 527 citations

Paxillin: a focal adhesion-associated adaptor protein

2001 • 520 citations

Activating SRC mutation in a subset of advanced human colon cancers

1999 • 473 citations

Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain

1987 • 410 citations

Protein-tyrosine Phosphatase Shp-2 Regulates Cell Spreading, Migration, and Focal Adhesion

1998 • 390 citations

The ‘Gab’ in signal transduction

2003 • 378 citations

ErbB Receptor-induced Activation of Stat Transcription Factors Is Mediated by Src Tyrosine Kinases

1999 • 365 citations

Paxillin interactions

2000 • 342 citations

Coupling of Gab1 to C-Met, Grb2, and Shp2 Mediates Biological Responses

2000 • 333 citations

Epidermal Growth Factor-Induced Tumor Cell Invasion and Metastasis Initiated by Dephosphorylation and Downregulation of Focal Adhesion Kinase

2001 • 325 citations

New Roles for Src Kinases in Control of Cell Survival and Angiogenesis

2000 • 301 citations

Shp-2 Tyrosine Phosphatase: Signaling One Cell or Many

1999 • 291 citations

Gab1 Acts as an Adapter Molecule Linking the Cytokine Receptor gp130 to ERK Mitogen-Activated Protein Kinase

1998 • 287 citations

The Tyrosine Phosphatase SHP-2 Is Required for Sustained Activation of Extracellular Signal-Regulated Kinase and Epithelial Morphogenesis Downstream from the Met Receptor Tyrosine Kinase

2000 • 278 citations

Concerted Activity of Tyrosine Phosphatase SHP-2 and Focal Adhesion Kinase in Regulation of Cell Motility

1999 • 254 citations

How to make tubes: signaling by the Met receptor tyrosine kinase

2003 • 236 citations

Analysis of the binding of the Src homology 2 domain of Csk to tyrosine-phosphorylated proteins in the suppression and mitotic activation of c-Src.

1994 • 230 citations

Detection of Src homology 3-binding proteins, including paxillin, in normal and v-Src-transformed Balb/c 3T3 cells

1993 • 222 citations

A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains.

1993 • 219 citations

Phosphorylation-Dependent Paxillin-ERK Association Mediates Hepatocyte Growth Factor-Stimulated Epithelial Morphogenesis

2003 • 214 citations

The Role of the Epidermal Growth Factor Receptor Family in Mammary Tumorigenesis and Metastasis

1999 • 190 citations

Phosphorylation-Dependent Regulation of T-Cell Activation by PAG/Cbp, a Lipid Raft-Associated Transmembrane Adaptor

2003 • 188 citations

Src family kinases and HER2 interactions in human breast cancer cell growth and survival

2001 • 187 citations

Localized suppression of RhoA activity by Tyr31/118-phosphorylated paxillin in cell adhesion and migration

2002 • 173 citations

Phosphotyrosines 627 and 659 of Gab1 Constitute a Bisphosphoryl Tyrosine-based Activation Motif (BTAM) Conferring Binding and Activation of SHP2

2001 • 160 citations

Regulation of the Mitogen-activated Protein Kinase Signaling Pathway by SHP2

2002 • 160 citations

Temporal and quantitative regulation of mitogen-activated protein kinase (MAPK) modulates cell motility and invasion

2001 • 158 citations

Role of Tyrosine Kinase Activity of Epidermal Growth Factor Receptor in the Lysophosphatidic Acid-stimulated Mitogen-activated Protein Kinase Pathway

1998 • 149 citations

Src and Ras are involved in separate pathways in epithelial cell scattering

1997 • 141 citations

A Critical Role for Phosphoinositide 3-Kinase Upstream of Gab1 and SHP2 in the Activation of Ras and Mitogen-activated Protein Kinases by Epidermal Growth Factor

2001 • 141 citations

Requirement for c-Src Catalytic Activity and the SH3 Domain in Platelet-derived Growth Factor BB and Epidermal Growth Factor Mitogenic Signaling

1996 • 135 citations

Requirement of SHP2 Binding to Grb2-associated Binder-1 for Mitogen-activated Protein Kinase Activation in Response to Lysophosphatidic Acid and Epidermal Growth Factor

2000 • 135 citations

An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity

2000 • 125 citations

Inhibition of Src Family Kinases Blocks Epidermal Growth Factor (EGF)-induced Activation of Akt, Phosphorylation of c-Cbl, and Ubiquitination of the EGF Receptor

2002 • 112 citations

Roles for the protein tyrosine phosphatase SHP-2 in cytoskeletal organization, cell adhesion and cell migration revealed by overexpression of a dominant negative mutant

2000 • 94 citations

Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation

2002 • 84 citations

Altered Expression of Protein-tyrosine Phosphatase 2C in 293 Cells Affects Protein Tyrosine Phosphorylation and Mitogen-activated Protein Kinase Activation

1995 • 83 citations

The Activated Insulin-Like Growth Factor I Receptor Induces Depolarization in Breast Epithelial Cells Characterized by Actin Filament Disassembly and Tyrosine Dephosphorylation of FAK, Cas, and Paxillin

1999 • 78 citations

Regulation of the Erk2-Elk1 signaling pathway and megakaryocytic differentiation of Bcr-Abl+ K562 leukemic cells by Gab2

2002 • 76 citations

The Src SH3 Domain Is Required for DNA Synthesis Induced by Platelet-derived Growth Factor and Epidermal Growth Factor

1996 • 62 citations

An Essential Role for Src Kinase in ErbB Receptor Signaling through the MAPK Pathway

2001 • 55 citations

Differential regulation of components of the focal adhesion complex by heregulin: Role of phosphatase SHP‐2

2002 • 53 citations

Site-Specific Association of c-SRC with Epidermal Growth Factor Receptor in A431 Cells

1995 • 51 citations

Interleukin-3 protects Bcr-Abl-transformed hematopoietic progenitor cells from apoptosis induced by Bcr-Abl tyrosine kinase inhibitors

2002 • 50 citations

Insulin-induced tyrosine dephosphorylation of paxillin and focal adhesion kinase requires active phosphotyrosine phosphatase 1D

1996 • 47 citations

RNA splicing regulates the activity of a SH2 domain-containing protein tyrosine phosphatase.

1994 • 25 citations

A Single Plasmid Vector (pSTAR) Mediating Efficient Tetracycline-Induced Gene Expression

1998 • 23 citations

Epidermal growth factor stimulation can substitute for c-Src overexpression in promoting breast carcinoma invasion

2003 • 15 citations

Simultaneous suppression of Erk and Akt/PKB activation by a Gab1 pleckstrin homology (PH) domain decoy.

2003 • 10 citations