An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity

β-Arrestin-Dependent Formation of β ₂ Adrenergic Receptor-Src Protein Kinase Complexes

1999 • 1,427 citations

Cytokine receptor signalling

1995 • 1,242 citations

Regulation, substrates and functions of src

1996 • 1,173 citations

Direct control of the Forkhead transcription factor AFX by protein kinase B

1999 • 1,080 citations

Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells.

1996 • 964 citations

Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein

1995 • 945 citations

Requirement for c-ras proteins during viral oncogene transformation

1986 • 680 citations

Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation

1998 • 666 citations

c-Src-mediated Phosphorylation of the Epidermal Growth Factor Receptor on Tyr845 and Tyr1101 Is Associated with Modulation of Receptor Function

1999 • 633 citations

Stat3 Activation Is Required for Cellular Transformation by v-src

1998 • 624 citations

Role of c-Src Tyrosine Kinase in G Protein-coupled Receptorand Gβγ Subunit-mediated Activation of Mitogen-activated Protein Kinases

1996 • 524 citations

Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring.

1990 • 522 citations

Mechanism of biological synergy between cellular Src and epidermal growth factor receptor

1999 • 468 citations

Gβγ Subunits Mediate Src-dependent Phosphorylation of the Epidermal Growth Factor Receptor

1997 • 456 citations

The small GTPase RalA targets filamin to induce filopodia

1999 • 449 citations

Multiple Ras Effector Pathways Contribute to G1Cell Cycle Progression

1999 • 414 citations

Focal Adhesion Kinase Overexpression Enhances Ras-dependent Integrin Signaling to ERK2/Mitogen-activated Protein Kinase through Interactions with and Activation of c-Src

1997 • 380 citations

Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells.

1997 • 370 citations

ErbB Receptor-induced Activation of Stat Transcription Factors Is Mediated by Src Tyrosine Kinases

1999 • 365 citations

EGF Receptor Signaling Stimulates SRC Kinase Phosphorylation of Clathrin, Influencing Clathrin Redistribution and EGF Uptake

1999 • 347 citations

Focal adhesion kinase in integrin-mediated signaling

1999 • 345 citations

All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral

1998 • 337 citations

Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.

1996 • 335 citations

Bridging Ral GTPase to Rho Pathways

1995 • 330 citations

Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: implications for the etiology of multiple human cancers.

1995 • 329 citations

Characterization of protein tyrosine kinases from human breast cancer: involvement of the c-src oncogene product.

1992 • 309 citations

Identification and Characterization of Ral-Binding Protein 1, a Potential Downstream Target of Ral GTPases

1995 • 304 citations

The Ras superfamily of GTPases ¹

1996 • 269 citations

Involvement of Ral GTPase in v-Src-induced phospholipase D activation

1995 • 261 citations

Calcium influx induces neurite growth through a Src-Ras signaling cassette

1995 • 261 citations

Src-mediated Tyrosine Phosphorylation of Dynamin Is Required for β2-Adrenergic Receptor Internalization and Mitogen-activated Protein Kinase Signaling

1999 • 259 citations

A Role for the Ral Guanine Nucleotide Dissociation Stimulator in Mediating Ras-induced Transformation

1996 • 245 citations

DNA Synthesis Induced by Some but Not All Growth Factors Requires Src Family Protein Tyrosine Kinases

1995 • 244 citations

c-Src, Receptor Tyrosine Kinases, and Human Cancer

1999 • 244 citations

Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity.

1994 • 233 citations

Association of p60c-src with endosomal membranes in mammalian fibroblasts.

1992 • 233 citations

Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts

1995 • 232 citations

Activation of STAT transcription factors in oncogenic tyrosine kinase signaling

1998 • 206 citations

A putative effector of Ral has homology to Rho/Rac GTPase activating proteins.

1995 • 176 citations

Stimulation of gene induction and cell growth by the Ras effector Rlf

1997 • 167 citations

Characterization of human epidermal growth factor receptor and c-Src interactions in human breast tumor cells

1998 • 165 citations

Src kinases and not JAKs activate STATs during IL-3 induced myeloid cell proliferation

1998 • 151 citations

Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6

1997 • 146 citations

Activation of the Small GTPase Ral in Platelets

1998 • 144 citations

Ras-like GTPases

1997 • 132 citations

Functional association between Arf and RalA in active phospholipase D complex

1998 • 131 citations

Src, a molecular switch governing gain control of synaptic transmission mediated by N- methyl- <scp>d</scp> -aspartate receptors

1999 • 120 citations

Role of c-Src tyrosine kinase in EGF-induced mitogenesis

1997 • 117 citations

Human β-Filamin Is a New Protein That Interacts with the Cytoplasmic Tail of Glycoprotein Ibα

1998 • 114 citations

Ras-dependent activation of the small GTPase Ral

1998 • 112 citations

Phospholipase D and RalA Cooperate with the Epidermal Growth Factor Receptor To Transform 3Y1 Rat Fibroblasts

2000 • 100 citations

Src interacts with dynamin and synapsin in neuronal cells

1998 • 89 citations

Constitutive Activation of JAK1 in Src-transformed Cells

1997 • 88 citations

Ral-Specific Guanine Nucleotide Exchange Factor Activity Opposes Other Ras Effectors in PC12 Cells by Inhibiting Neurite Outgrowth

1999 • 88 citations

Activation and Translocation of c-Src to the Cytoskeleton by Both Platelet-derived Growth Factor and Epidermal Growth Factor

1995 • 86 citations

Molecular Cloning of Human ABPL, an Actin-Binding Protein Homologue

1998 • 83 citations

Ras-independent activation of Ral by a Ca2+-dependent pathway

1998 • 79 citations

Specific association of the proto-oncogene product pp60c-src with an intracellular organelle, the PC12 synaptic vesicle

1992 • 76 citations

Translocation of pp60c-src from the plasma membrane to the cytosol after stimulation by platelet-derived growth factor.

1993 • 73 citations

Ra1 and Rab3a are major GTP-binding proteins of axonal rapid transport and synaptic vesicles and do not redistribute following depolarization stimulated synaptosomal exocytosis

1993 • 70 citations

Synapsin I interacts with c-Src and stimulates its tyrosine kinase activity

1997 • 69 citations

c-Src Activates both STAT1 and STAT3 in PDGF-Stimulated NIH3T3 Cells

1997 • 68 citations

Synergistic activation of c-fos promoter activity by Raf and Ral GDP dissociation stimulator

1997 • 63 citations

rsc: a novel oncogene with structural and functional homology with the gene family of exchange factors for Ral

1997 • 60 citations

Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity

1994 • 56 citations

Activation Of The Src Family Of Tyrosine Kinases In Mammary Tumorigenesis

1994 • 40 citations

Differential fMet-Leu-Phe- and Platelet-activating Factor-induced Signaling Toward Ral Activation in Primary Human Neutrophils

1999 • 37 citations