Insulin-induced tyrosine dephosphorylation of paxillin and focal adhesion kinase requires active phosphotyrosine phosphatase 1D

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

The insulin signaling system.

1994 • 1,733 citations

Integrins: Emerging Paradigms of Signal Transduction

1995 • 1,591 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor

1982 • 1,138 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation.

1992 • 1,030 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

1994 • 1,020 citations

Protein Tyrosine Phosphatases: A Diverse Family of Intracellular and Transmembrane Enzymes

1991 • 973 citations

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 • 972 citations

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

1994 • 923 citations

Insulin Action, Diabetogenes, and the Cause of Type II Diabetes

1994 • 914 citations

Human Sos1: a Guanine Nucleotide Exchange Factor for Ras that Binds to GRB2

1993 • 788 citations

Crystal Structure of Human Protein Tyrosine Phosphatase 1B

1994 • 747 citations

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1994 • 728 citations

The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.

1993 • 705 citations

Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets.

1992 • 669 citations

IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85.

1992 • 471 citations

Focal adhesion kinase (p125FAK): A point of convergence in the action of neuropeptides, integrins, and oncogenes

1992 • 453 citations

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1.

1993 • 452 citations

1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells.

1994 • 436 citations

Involvement of p21ras in activation of extracellular signal-regulated kinase 2

1992 • 403 citations

The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp

1993 • 384 citations

Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.

1993 • 377 citations

Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation.

1994 • 369 citations

Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin

1994 • 362 citations

Association of insulin receptor substrate-1 with integrins

1994 • 362 citations

Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak- binding region

1994 • 311 citations

Insulin-induced phosphorylation of the 46- and 52-kDa Shc proteins.

1993 • 308 citations

Platelet-derived growth factor modulation of focal adhesion kinase (p125FAK) and paxillin tyrosine phosphorylation in Swiss 3T3 cells. Bell-shaped dose response and cross-talk with bombesin.

1994 • 305 citations

Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin.

1994 • 302 citations

Insulin stimulation of gene expression mediated by p21ras activation.

1991 • 284 citations

Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase

1995 • 277 citations

Lysophosphatidic acid stimulates tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130. Signaling pathways and cross-talk with platelet-derived growth factor.

1994 • 264 citations

Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling.

1995 • 263 citations

Insulin receptor substrate-1 mediates phosphatidylinositol 3'-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation.

1994 • 257 citations

Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway.

1994 • 239 citations

Disassembly of the actin network inhibits insulin-dependent stimulation of glucose transport and prevents recruitment of glucose transporters to the plasma membrane.

1994 • 204 citations

Shc is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21ras-GTP formation.

1994 • 200 citations

Tyrosyl phosphorylation and growth factor receptor association of the human corkscrew homologue, SH-PTP2

1993 • 192 citations

Focal adhesion kinase: an integrin-linked protein tyrosine kinase

1993 • 177 citations

Involvement of She in Insulin- and Epidermal Growth Factor-Induced Activation of p21^ras

1994 • 174 citations

CD45. A prototype for transmembrane protein tyrosine phosphatases.

1991 • 142 citations

Tyrosine phosphorylation of the focal adhesion kinase pp125FAK during development: relation to paxillin

1993 • 139 citations

Insulin-dependent formation of a complex containing an 85-kDa subunit of phosphatidylinositol 3-kinase and tyrosine-phosphorylated insulin receptor substrate 1.

1992 • 119 citations

Role of SH-PTP2, a Protein-Tyrosine Phosphatase with Src Homology 2 Domains, in Insulin-Stimulated Ras Activation

1994 • 108 citations

Upstream Mechanisms of Glycogen Synthase Activation by Insulin and Insulin-like Growth Factor-I

1995 • 107 citations

Pleiotropic Insulin Signals are Engaged by Multisite Phosphorylation of IRS-1

1993 • 107 citations

The torso receptor protein-tyrosine kinase signaling pathway: An endless story

1993 • 101 citations

Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2

1993 • 100 citations

Identification of a 190-kDa Protein as a Novel Substrate for the Insulin Receptor Kinase Functionally Similar to Insulin Receptor Substrate-1

1995 • 86 citations

A mutant insulin receptor induces formation of a Shc-growth factor receptor bound protein 2 (Grb2) complex and p21ras-GTP without detectable interaction of insulin receptor substrate 1 (IRS1) with Grb2. Evidence for IRS1-independent p21ras-GTP formation

1994 • 76 citations

Insulin Stimulates the Tyrosine Dephosphorylation of pp125 Focal Adhesion Kinase

1995 • 74 citations

A complex of GRB2-dynamin binds to tyrosine-phosphorylated insulin receptor substrate-1 after insulin treatment.

1994 • 71 citations

Insulin-induced p21ras activation does not require protein kinase C, but a protein sensitive to phenylarsine oxide.

1991 • 51 citations

Protein-tyrosine Phosphatase 1D Modulates Its Own State of Tyrosine Phosphorylation

1995 • 47 citations

Expression of a dominant-negative Ras mutant does not affect stimulation of glucose uptake and glycogen synthesis by insulin

1996 • 40 citations

Stimulation of tyrosine‐ and serine‐phosphorylation of focal adhesion kinase in mouse 3T3 cells by fibronectin and fibroblast growth factor

1994 • 40 citations