Tyrosyl Phosphorylation of Shp2 Is Required for Normal ERK Activation in Response to Some, but Not All, Growth Factors

Cell Signaling by Receptor Tyrosine Kinases

2000 • 3,570 citations

Signaling—2000 and Beyond

2000 • 2,544 citations

Mitogen-activated protein kinase pathways

1997 • 2,513 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

Organization and regulation of mitogen-activated protein kinase signaling pathways

1999 • 1,288 citations

A Lipid-Anchored Grb2-Binding Protein That Links FGF-Receptor Activation to the Ras/MAPK Signaling Pathway

1997 • 861 citations

Protein tyrosine phosphatases in signal transduction

1997 • 766 citations

Src family kinases are required for integrin but not PDGFR signal transduction

1999 • 733 citations

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1996 • 674 citations

SH2-Containing Phosphotyrosine Phosphatase as a Target of Protein-Tyrosine Kinases

1993 • 666 citations

SU6656, a Selective Src Family Kinase Inhibitor, Used To Probe Growth Factor Signaling

2000 • 577 citations

Activation of a Phosphotyrosine Phosphatase by Tyrosine Phosphorylation

1993 • 554 citations

Combinatorial control of the specificity of protein tyrosine phosphatases

2001 • 500 citations

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

1994 • 477 citations

Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2

1997 • 474 citations

Activation of BTK by a Phosphorylation Mechanism Initiated by SRC Family Kinases

1996 • 445 citations

c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

1999 • 420 citations

Src Family Tyrosine Kinases and Growth Factor Signaling

2000 • 391 citations

Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.

1994 • 389 citations

The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp

1993 • 384 citations

Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation.

1994 • 369 citations

Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew.

1992 • 359 citations

Binding of Shp2 Tyrosine Phosphatase to FRS2 Is Essential for Fibroblast Growth Factor-Induced PC12 Cell Differentiation

1998 • 322 citations

Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor.

1993 • 319 citations

Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2

1998 • 297 citations

Shp-2 Tyrosine Phosphatase: Signaling One Cell or Many

1999 • 291 citations

Gab1 Acts as an Adapter Molecule Linking the Cytokine Receptor gp130 to ERK Mitogen-Activated Protein Kinase

1998 • 287 citations

Receptor-Specific Regulation of Phosphatidylinositol 3′-Kinase Activation by the Protein Tyrosine Phosphatase Shp2

2002 • 268 citations

Site-Specific Incorporation of a Phosphotyrosine Mimetic Reveals a Role for Tyrosine Phosphorylation of SHP-2 in Cell Signaling

2001 • 261 citations

Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes

1998 • 261 citations

Multiple Requirements for SHPTP2 in Epidermal Growth Factor-Mediated Cell Cycle Progression

1996 • 247 citations

A phosphotyrosine displacement mechanism for activation of Src by PTPα

2000 • 236 citations

Molecular Mechanism for the Shp-2 Tyrosine Phosphatase Function in Promoting Growth Factor Stimulation of Erk Activity

2000 • 230 citations

Regulation of Early Events in Integrin Signaling by Protein Tyrosine Phosphatase SHP-2

1999 • 219 citations

The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp.

1993 • 214 citations

PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation

1994 • 214 citations

Conditional Inhibition of the Mitogen-activated Protein Kinase Cascade by Wortmannin

1997 • 196 citations

Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo.

1994 • 192 citations

Tyrosyl phosphorylation and growth factor receptor association of the human corkscrew homologue, SH-PTP2

1993 • 192 citations

A Deletion Mutation in the SH2-N Domain of Shp-2 Severely Suppresses Hematopoietic Cell Development

1997 • 167 citations

The Shp-2 Tyrosine Phosphatase Has Opposite Effects in Mediating the Activation of Extracellular Signal-regulated and c-Jun NH2-terminal Mitogen-activated Protein Kinases

1998 • 155 citations

Genetic analysis of protein tyrosine phosphatases

1998 • 145 citations

Biased Suppression of Hematopoiesis and Multiple Developmental Defects in Chimeric Mice Containing Shp-2 Mutant Cells

1998 • 130 citations

Structural Determinants of SHP-2 Function and Specificity in Xenopus Mesoderm Induction

1998 • 115 citations

Use of the two hybrid system to detect the association of the protein-tyrosine-phosphatase, SHPTP2, with another SH2-containing protein, Grb7.

1996 • 98 citations

New insights into the regulation and functions of Tec family tyrosine kinases in the immune system

2002 • 91 citations

Receptor tyrosine phosphatase R-PTP-alpha is tyrosine-phosphorylated and associated with the adaptor protein Grb2.

1994 • 77 citations

Shp-2 mediates v-Src-induced morphological changes and activation of the anti-apoptotic protein kinase Akt

2000 • 74 citations

Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via tyrosine 584.

1996 • 71 citations

Two mechanisms activate PTPalpha during mitosis

2001 • 65 citations

Protein-tyrosine Phosphatase 1D Modulates Its Own State of Tyrosine Phosphorylation

1995 • 47 citations

Shp‐2 Specifically Regulates Several Tyrosine‐Phosphorylated Proteins in Brain‐Derived Neurotrophic Factor Signal

2000 • 37 citations

Mutational Analysis of the SRC Homology 2 Domain Protein-tyrosine Phosphatase Corkscrew

1998 • 25 citations