Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Inducible Gene Targeting in Mice

1995 • 1,897 citations

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

2001 • 1,824 citations

Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis

2002 • 1,700 citations

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

2001 • 1,678 citations

Chronic Myeloid Leukemia

1999 • 1,639 citations

The roles of FLT3 in hematopoiesis and leukemia

2002 • 1,485 citations

The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

2003 • 1,192 citations

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

2001 • 1,145 citations

Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

2003 • 1,019 citations

Versatile retroviral vectors for potential use in gene therapy.

1994 • 690 citations

MAP Kinase Phosphatase As a Locus of Flexibility in a Mitogen-Activated Protein Kinase Signaling Network

2002 • 647 citations

Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells

1996 • 602 citations

Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

2003 • 550 citations

An Mll–AF9 Fusion Gene Made by Homologous Recombination Causes Acute Leukemia in Chimeric Mice: A Method to Create Fusion Oncogenes

1996 • 534 citations

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

2003 • 532 citations

Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

2001 • 516 citations

FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model

2002 • 501 citations

Signaling Networks

2000 • 458 citations

APMLRARα transgene initiates murine acute promyelocytic leukemia

1997 • 455 citations

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

2002 • 446 citations

Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice

2002 • 419 citations

Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry–based novel culture system

2003 • 390 citations

Prognostic factors and scoring systems in chronic myelomonocytic leukemia: a retrospective analysis of 213 patients

2002 • 372 citations

Analysis of RAS gene mutations in acute myeloid leukemia by polymerase chain reaction and oligonucleotide probes.

1988 • 367 citations

Expression of a Knocked-In AML1-ETO Leukemia Gene Inhibits the Establishment of Normal Definitive Hematopoiesis and Directly Generates Dysplastic Hematopoietic Progenitors

1998 • 362 citations

Nf1 deficiency causes Ras-Dediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia

1996 • 310 citations

Homozygous Inactivation of theNF1Gene in Bone Marrow Cells from Children with Neurofibromatosis Type 1 and Malignant Myeloid Disorders

1997 • 292 citations

In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia

2002 • 285 citations

Neurofibromatosis and childhood leukaemia/lymphoma: a population-based UKCCSG study

1994 • 284 citations

Simultaneous measurement of multiple active kinase states using polychromatic flow cytometry

2002 • 282 citations

Expression of a Knocked-In AML1-ETO Leukemia Gene Inhibits the Establishment of Normal Definitive Hematopoiesis and Directly Generates Dysplastic Hematopoietic Progenitors

1998 • 280 citations

Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations.

1994 • 272 citations

GTPase activating proteins: critical regulators of intracellular signaling

2002 • 218 citations

Activity of the farnesyl protein transferase inhibitor SCH66336 against BCR/ABL-induced murine leukemia and primary cells from patients with chronic myeloid leukemia

2001 • 184 citations

Occurrence of myeloproliferative disorder in patients with Noonan syndrome

1997 • 176 citations

Genetic analysis is consistent with the hypothesis that NF1 limits myeloid cell growth through p21ras

1994 • 172 citations

RAS mutations in myelodysplasia detected by amplification, oligonucleotide hybridization, and transformation.

1988 • 162 citations

Mutant N-ras Induces Myeloproliferative Disorders and Apoptosis in Bone Marrow Repopulated Mice

1999 • 110 citations

Recurring chromosomal abnormalities in leukemia inPML-RARA transgenic mice parallel human acute promyelocytic leukemia

2002 • 87 citations

Mutant N-RAS Induces Erythroid Lineage Dysplasia in Human CD34+ Cells

1997 • 73 citations

Hyperactivation of protein kinase B and ERK have discrete effects on survival, proliferation, and cytokine expression in Nf1-deficient myeloid cells

2002 • 66 citations

Rare occurrence of N-ras point mutations in Philadelphia chromosome positive chronic myeloid leukemia

1989 • 65 citations

Expression of the NUP98/HOXA9 fusion transcript in the blast crisis of Philadelphia chromosome‐positive chronic myelogenous leukaemia with t(7;11)(p15;p15)

2000 • 63 citations

Studying the pathogenesis of BCR–ABL+ leukemia in mice

2002 • 58 citations

Comprehensive genotypic analysis of leukemia: clinical and therapeutic implications

2002 • 49 citations

Mutational activation of the N-ras oncogene assessed in primary clonogenic culture of acute myeloid leukemia (AML): implications for the role of N-ras mutation in AML pathogenesis

1992 • 43 citations

Mutational activation of the N-ras oncogene assessed in primary clonogenic culture of acute myeloid leukemia (AML): implications for the role of N-ras mutation in AML pathogenesis

1992 • 30 citations

Protein kinase C mediates mutant N-Ras–induced developmental abnormalities in normal human erythroid cells

2002 • 27 citations

Introduction of an activated RAS oncogene into murine bone marrow lymphoid progenitors via retroviral gene transfer results in thymic lymphomas.

1991 • 22 citations