Mouse model of Noonan syndrome reveals cell type– and gene dosage–dependent effects of Ptpn11 mutation

Missing Pieces in the NF-κB Puzzle

2002 • 3,560 citations

Met, metastasis, motility and more

2003 • 2,526 citations

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

2001 • 1,678 citations

Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice

2000 • 1,218 citations

The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

2003 • 1,192 citations

Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

2003 • 1,019 citations

The triple origin of skull in higher vertebrates: a study in quail-chick chimeras

1993 • 981 citations

Crystal Structure of the Tyrosine Phosphatase SHP-2

1998 • 940 citations

Endogenous oncogenic K-rasG12D stimulates proliferation and widespread neoplastic and developmental defects

2004 • 780 citations

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

1994 • 777 citations

PTPN11 Mutations in Noonan Syndrome: Molecular Spectrum, Genotype-Phenotype Correlation, and Phenotypic Heterogeneity

2002 • 765 citations

Rhombencephalic neural crest segmentation is preserved throughout craniofacial ontogeny

1996 • 681 citations

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues.

1994 • 634 citations

Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement

2002 • 582 citations

Hypertelorism With Turner Phenotype

1968 • 533 citations

Shp2 Regulates Src Family Kinase Activity and Ras/Erk Activation by Controlling Csk Recruitment

2004 • 437 citations

Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis

2003 • 429 citations

Spatial and temporal patterns of ERK signaling during mouse embryogenesis

2003 • 379 citations

Critical role for Gab2 in transformation by BCR/ABL

2002 • 363 citations

The Ullrich-Noonan Syndrome (Turner Phenotype)

1974 • 306 citations

Noonan syndrome.

1987 • 304 citations

Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2

1998 • 297 citations

Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder

2003 • 297 citations

Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia

2004 • 295 citations

Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease

2004 • 264 citations

Role of Gab1 in Heart, Placenta, and Skin Development and Growth Factor- and Cytokine-Induced Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Activation

2000 • 258 citations

Congenital heart diseases in children with Noonan syndrome: An expanded cardiac spectrum with high prevalence of atrioventricular canal

1999 • 250 citations

Tyrosyl Phosphorylation of Shp2 Is Required for Normal ERK Activation in Response to Some, but Not All, Growth Factors

2003 • 221 citations

Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation

2004 • 183 citations

Neurofibromin modulation of ras activity is required for normal endocardial-mesenchymal transformation in the developing heart

1998 • 180 citations

Occurrence of myeloproliferative disorder in patients with Noonan syndrome

1997 • 176 citations

Noonan Syndrome

1994 • 173 citations

Nf1 has an essential role in endothelial cells

2002 • 161 citations

Spectrum of mutations in PTPN11 and genotype–phenotype correlation in 96 patients with Noonan syndrome and five patients with cardio-facio-cutaneous syndrome

2003 • 158 citations

Modulation of the Nuclear Factor κb Pathway by Shp-2 Tyrosine Phosphatase in Mediating the Induction of Interleukin (Il)-6 by IL-1 or Tumor Necrosis Factor

2001 • 130 citations

Activated Mutants of SHP-2 Preferentially Induce Elongation of Xenopus Animal Caps

2000 • 117 citations

PTPN11(Protein-Tyrosine Phosphatase, Nonreceptor-Type 11) Mutations in Seven Japanese Patients with Noonan Syndrome

2002 • 112 citations

PTPN11 Mutations in Noonan syndrome type I: detection of recurrent mutations in exons 3 and 13

2002 • 87 citations

Distinct Domains in the SHP-2 Phosphatase Differentially Regulate Epidermal Growth Factor Receptor/NF-κB Activation through Gab1 in Glioblastoma Cells

2003 • 74 citations

Developing models of DiGeorge syndrome

2001 • 70 citations

Noonan's Syndrome: Abnormalities of the Growth Hormone/IGF‐I Axis and the Response to Treatment with Human Biosynthetic Growth Hormone

1991 • 69 citations

Noonan syndrome: Structural abnormalities of the mitral valve causing subaortic obstruction

1995 • 45 citations

Noonan syndrome and aortic coarctation

1998 • 44 citations

Tie2-Cre–Induced Inactivation of a Conditional Mutant Nf1 Allele in Mouse Results in a Myeloproliferative Disorder that Models Juvenile Myelomonocytic Leukemia

2004 • 42 citations

Hematopoiesis: Progenitors and their genetic program

1998 • 37 citations

Cardiac findings in 31 patients with Noonan's syndrome

2000 • 31 citations

Exclusion of allelism of Noonan syndrome and neurofibromatosis-type 1 in a large family with Noonan syndrome-neurofibromatosis association

1996 • 27 citations

Noonan's Syndrome in Association with Acute Leukemia

1995 • 27 citations