Analysis of CpG methylation and genomic footprinting at the tyrosine aminotransferase gene: DNA methylation alone is not sufficient to prevent protein binding in vivo.

Genomic sequencing.

1984 • 8,343 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.

1986 • 1,424 citations

Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins

1985 • 1,248 citations

DNA METHYLATION AND GENE ACTIVITY

1983 • 1,115 citations

The Inheritance of Epigenetic Defects

1987 • 1,058 citations

Isolation of a recombinant copy of the gene encoding C/EBP.

1988 • 1,003 citations

DNA methylation and gene activity

1988 • 904 citations

B Lineage—Specific Interactions of an Immunoglobulin Enhancer with Cellular Factors in Vivo

1985 • 859 citations

Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene

1987 • 760 citations

DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein

1991 • 722 citations

Transcriptional selectivity of viral genes in mammalian cells

1986 • 722 citations

High levels of De Novo methylation and altered chromatin structure at CpG islands in cell lines

1990 • 709 citations

Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs

1989 • 655 citations

Sequence-specific positioning of nucleosomes over the steroid-inducible MMTV promoter.

1987 • 597 citations

DNA methylation affects the formation of active chromatin

1986 • 588 citations

Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter.

1988 • 587 citations

CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation.

1989 • 554 citations

Induction of tyrosine alpha-ketoglutarate transaminase by steroid hormones in a newly established tissue culture cell line.

1966 • 484 citations

Removal of positioned nucleosomes from the yeast PHO5 promoter upon PHO5 induction releases additional upstream activating DNA elements.

1986 • 470 citations

Steroid-dependent interaction of transcription factors with the inducible promoter of mouse mammary tumor virus in vivo

1987 • 448 citations

CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2

1990 • 426 citations

Altering gene expression with 5-azacytidine

1985 • 408 citations

The somatic replication of DNA methylation

1981 • 368 citations

A genetic analysis of extinction: Trans-dominant loci regulate expression of liver-specific traits in hepatoma hybrid cells

1984 • 365 citations

Methylation of the Hprt gene on the inactive X occurs after chromosome inactivation

1987 • 363 citations

Genomic footprinting reveals cell type-specific DNA binding of ubiquitous factors

1987 • 356 citations

5-azacytidine induction of stable mesodermal stem cell lineages from 10T1/2 cells: Evidence for regulatory genes controlling determination

1984 • 330 citations

Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated.

1988 • 308 citations

Role of an adenovirus E2 promoter binding factor in E1A-mediated coordinate gene control.

1987 • 290 citations

Chromatin structure is required to block transcription of the methylated herpes simplex virus thymidine kinase gene.

1987 • 241 citations

Genomic sequencing reveals a positive correlation between the kinetics of strand-specific DNA demethylation of the overlapping estradiol/glucocorticoid-receptor binding sites and the rate of avian vitellogenin mRNA synthesis.

1986 • 224 citations

Glucocorticoids are required for establishment and maintenance of an alteration in chromatin structure: induction leads to a reversible disruption of nucleosomes over an enhancer.

1991 • 206 citations

Cytosine methylation does not affect binding of transcription factor Sp1.

1988 • 201 citations

Specific protection of methylated CpGs in mammalian nuclei

1989 • 195 citations

DNA methylation stabilizes X chromosome inactivation in eutherians but not in marsupials: evidence for multistep maintenance of mammalian X dosage compensation.

1987 • 171 citations

A cyclic AMP response element mediates repression of tyrosine aminotransferase gene transcription by the tissue-specific extinguisher locus Tse-1

1990 • 154 citations

Role of trans-activating proteins in the generation of active chromatin at the PHO5 promoter in S. cerevisiae.

1990 • 143 citations

Tissue-specific DNaseI hypersensitive sites in the 5′-flanking sequences of the tryptophan oxygenase and the tyrosine aminotransferase genes.

1984 • 135 citations

Glucocorticoid receptor-dependent disruption of a specific nucleosome on the mouse mammary tumor virus promoter is prevented by sodium butyrate.

1990 • 135 citations

5-methylcytosine is localized in nucleosomes that contain histone H1.

1983 • 97 citations

In vivo monitoring of a cAMP-stimulated DNA-binding activity.

1990 • 93 citations

Demethylation of specific sites in the 5' region of the inactive X-linked human phosphoglycerate kinase gene correlates with the appearance of nuclease sensitivity and gene expression.

1988 • 90 citations

DNA methylation in 5-aza-2'-deoxycytidine-resistant variants of C3H 10T1/2 C18 cells.

1984 • 76 citations

Chromatin structures of the rat tyrosine aminotransferase gene relate to the function of its cis-acting elements.

1990 • 67 citations

DNA methylation: a secondary event in globin gene switching?

1988 • 62 citations

Human methylated DNA-binding protein. Determinants of a pBR322 recognition site.

1988 • 59 citations

Gene structure and transcription in mouse cells with extensively demethylated DNA.

1989 • 47 citations

New approaches to chromatin function.

1990 • 45 citations

Effects of 5-azacytidine on methylation and expression of specific DNA sequences in C3H 10T1/2 cells.

1984 • 39 citations

Reactivation of thyroglobulin gene expression in transformed thyroid cells by 5-azacytidine

1989 • 39 citations

Demethylation of Specific Sites in the 5′ Region of the Inactive X-Linked Human Phosphoglycerate Kinase Gene Correlates with the Appearance of Nuclease Sensitivity and Gene Expression

1988 • 33 citations

Site-Specific Demethylation and Normal Chromatin Structure of the Human Dihydrofolate Reductase Gene Promoter after Transfection into CHO Cells

1987 • 32 citations

A novel and rapid method to generate single stranded DNA probes for genomic footprinting

1988 • 23 citations

DNA Methylation in 5-Aza-2′-Deoxycytidine-Resistant Variants of C3H 10T1/2 C18 Cells

1984 • 19 citations

Chromatin Structures of the Rat Tyrosine Aminotransferase Gene Relate to the Function of Its cis-Acting Elements

1990 • 19 citations

Gene Structure and Transcription in Mouse Cells with Extensively Demethylated DNA

1989 • 15 citations

Effects of 5-Azacytidine on Methylation and Expression of Specific DNA Sequences in C3H 10T1/2 Cells

1984 • 12 citations