Cell and molecular neurobiology of presenilins: A role for the endoplasmic reticulum in the pathogenesis of Alzheimer's disease?

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1995 • 3,985 citations

Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus

1995 • 2,548 citations

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1996 • 2,543 citations

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1995 • 2,028 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

1996 • 1,467 citations

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

1996 • 1,439 citations

Amyloid, the presenilins and Alzheimer's disease

1997 • 1,370 citations

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

1993 • 1,035 citations

Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo

1996 • 1,013 citations

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

1997 • 991 citations

Notch1 is required for the coordinate segmentation of somites

1995 • 860 citations

Estrogens Attenuate and Corticosterone Exacerbates Excitotoxicity, Oxidative Injury, and Amyloid β‐Peptide Toxicity in Hippocampal Neurons

1996 • 833 citations

A Familial Alzheimer's Disease Locus on Chromosome 1

1995 • 810 citations

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein

1993 • 800 citations

A Role for 4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, in Disruption of Ion Homeostasis and Neuronal Death Induced by Amyloid β‐Peptide

1997 • 779 citations

Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease

1994 • 749 citations

Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis

1997 • 727 citations

Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm

1997 • 721 citations

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1995 • 705 citations

Immunohistochemical evidence for apoptosis in Alzheimerʼs disease

1994 • 569 citations

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death

1995 • 559 citations

Alzheimer–associated presenilins 1 and 2 : Neuronal expression in brain and localization to intracellular membranes in mammalian cells

1996 • 549 citations

Amyloid β-Peptide Impairs Glucose Transport in Hippocampal and Cortical Neurons: Involvement of Membrane Lipid Peroxidation

1997 • 543 citations

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

1997 • 488 citations

Evidence for Apoptotic Cell Death in Alzheimer's Disease

1995 • 482 citations

Interfering with Apoptosis: Ca ²⁺ -Binding Protein ALG-2 and Alzheimer's Disease Gene ALG-3

1996 • 481 citations

Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14

1992 • 458 citations

Participation of Presenilin 2 in Apoptosis: Enhanced Basal Activity Conferred by an Alzheimer Mutation

1996 • 424 citations

Increased Activity‐Regulating and Neuroprotective Efficacy of α‐Secretase‐Derived Secreted Amyloid Precursor Protein Conferred by a C‐Terminal Heparin‐Binding Domain

1996 • 387 citations

Alzheimer’s Presenilin Mutation Sensitizes Neural Cells to Apoptosis Induced by Trophic Factor Withdrawal and Amyloid β-Peptide: Involvement of Calcium and Oxyradicals

1997 • 386 citations

Protein Topology of Presenilin 1

1996 • 374 citations

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

1996 • 360 citations

Are reactive oxygen species involved in Alzheimer's disease?

1995 • 358 citations

Stress exacerbates neuron loss and cytoskeletal pathology in the hippocampus

1994 • 325 citations

Alzheimerʼs PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid β-peptide

1996 • 321 citations

Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease.

1994 • 319 citations

Expression of Presenilin 1 and 2 (PS1 and PS2) in Human and Murine Tissues

1996 • 290 citations

Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons

1990 • 283 citations

Lymphocyte Apoptosis: Mediation by Increased Type 3 Inositol 1,4,5-Trisphosphate Receptor

1996 • 268 citations

Calcium‐Activated Neutral Proteinase (Calpain) System in Aging and Alzheimer's Disease^a

1994 • 254 citations

Calcium as sculptor and destroyer of neural circuitry

1992 • 250 citations

The Alzheimer’s Disease-Associated Presenilins Are Differentially Phosphorylated Proteins Located Predominantly within the Endoplasmic Reticulum

1996 • 229 citations

Formation of stable complexes between two Alzheimer's disease gene products: Presenilin-2 and β-amyloid precursor protein

1997 • 216 citations

Membrane Topology of the C. elegans SEL-12 Presenilin

1996 • 204 citations

Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites.

1996 • 203 citations

Complementary and combinatorial patterns of Notch gene family expression during early mouse development

1995 • 172 citations

Light and Electron Microscopic Localization of Presenilin-1 in Primate Brain

1997 • 166 citations

Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions.

1992 • 159 citations

Evidence for a Six-transmembrane Domain Structure of Presenilin 1

1997 • 154 citations

Alzheimer‐associated presenilin‐2 confers increased sensitivity to poptosis in PC12 cells

1996 • 132 citations

Analysis of the 5′ Sequence, Genomic Structure, and Alternative Splicing of thepresenilin-1Gene (PSEN1) Associated with Early Onset Alzheimer Disease

1997 • 126 citations

Characterization of human presenilin 1 using N‐terminal specific monoclonal antibodies: Evidence that Alzheimer mutations affect proteolytic processing

1996 • 122 citations

Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains

1996 • 91 citations

Neuronal Localization of Presenilin-1 and Association with Amyloid Plaques and Neurofibrillary Tangles in Alzheimer’s Disease

1997 • 89 citations

Regional and CellularPresenilin 1Gene Expression in Human and Rat Tissues

1996 • 70 citations

Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains

1996 • 69 citations

Developmental Regulation of Presenilin mRNA Expression Parallels Notch Expression

1997 • 68 citations

Widespread neuronal expression of the presenilin-1 early-onset Alzheimer's disease gene in the murine brain.

1996 • 56 citations

Decreased Inositol (1,4,5)-Trisphosphate Receptor Levels in Alzheimer's Disease Cerebral Cortex: Selectivity of Changes and Possible Correlation to Pathological Severity

1996 • 53 citations

Presenilin-1-immunoreactive neurons are preserved in late-onset Alzheimer's disease.

1997 • 53 citations

In situ hybridization analysis of presenilin 1 mRNA in Alzheimer disease and in lesioned rat brain

1996 • 46 citations

Widespread immunoreactivity of presenilin in neurons of normal and Alzheimer's disease brains: double-labeling immunohistochemical study

1996 • 40 citations

Calcium Homeostasis and Free Radical Metabolism as Convergence Points in the Pathophysiology of Dementia

1997 • 37 citations

Discussion

1997 • 31 citations

Presenilin-1 Immunoreactivity Is Localized Intracellularly in Alzheimer's Disease Brain, but Not Detected in Amyloid Plaques

1997 • 27 citations

Nerve Growth Factor-independent Reduction in Choline Acetyltransferase Activity in PC12 Cells Expressing Mutant Presenilin-1

1997 • 22 citations

Alteration of acylphosphatase levels in familial Alzheimer's disease fibroblasts with presenilin gene mutations

1996 • 18 citations

Calcium Homeostasis and Free Radical Metabolism as Convergence Points in the Pathophysiology of Dementia

2003 • 12 citations