Caspase-3-induced gelsolin fragmentation contributes to actin cytoskeletal collapse, nucleolysis, and apoptosis of vascular smooth muscle cells exposed to proinflammatory cytokines

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

1994 • 1,239 citations

Caspase-3-Generated Fragment of Gelsolin: Effector of Morphological Change in Apoptosis

1997 • 1,233 citations

Control of cytoplasmic actin gel–sol transformation by gelsolin, a calcium-dependent regulatory protein

1979 • 782 citations

Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques.

1995 • 700 citations

Apoptosis in Human Atherosclerosis and Restenosis

1995 • 684 citations

Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzyme.

1995 • 643 citations

Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate

1987 • 624 citations

Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death.

1996 • 621 citations

Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death).

1993 • 554 citations

Evidence for apoptosis in human atherogenesis and in a rat vascular injury model.

1995 • 484 citations

CPP32/Apopain Is a Key Interleukin 1β Converting Enzyme-like Protease Involved in Fas-mediated Apoptosis

1996 • 480 citations

Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain

1986 • 477 citations

Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin

1995 • 437 citations

Apoptosis of Vascular Smooth Muscle Cells Induced by In Vitro Stimulation With Interferon-γ, Tumor Necrosis Factor–α, and Interleukin-1β

1996 • 435 citations

Mechanisms of actin rearrangements mediating platelet activation.

1992 • 413 citations

Cleavage of actin by interleukin 1 beta-converting enzyme to reverse DNase I inhibition.

1996 • 298 citations

Apoptosis participates in cellularity regulation during rat aortic intimal thickening.

1995 • 285 citations

Fas Is Expressed in Human Atherosclerotic Intima and Promotes Apoptosis of Cytokine-Primed Human Vascular Smooth Muscle Cells

1997 • 270 citations

The Actin-Severing Protein Gelsolin Modulates Calcium Channel and NMDA Receptor Activities and Vulnerability to Excitotoxicity in Hippocampal Neurons

1997 • 269 citations

Gelsolin is a downstream effector of rac for fibroblast motility

1998 • 267 citations

Structure of Recombinant Human CPP32 in Complex with the Tetrapeptide Acetyl-Asp-Val-Ala-Asp Fluoromethyl Ketone

1997 • 245 citations

Structure and biosynthesis of cytoplasmic and secreted variants of gelsolin.

1984 • 215 citations

Identification of Actin as a Substrate of ICE and an ICE-like Protease and Involvement of an ICE-like Protease but Not ICE in Vp-16-Induced U937 Apoptosis

1995 • 210 citations

Control of Actin Assembly at Filament Ends

1995 • 202 citations

Deregulated expression of the c-myc oncogene abolishes inhibition of proliferation of rat vascular smooth muscle cells by serum reduction, interferon-gamma, heparin, and cyclic nucleotide analogues and induces apoptosis.

1994 • 200 citations

Apoptosis (Programmed Cell Death) in Arteries of the Neonatal Lamb

1995 • 200 citations

Identification of critical functional and regulatory domains in gelsolin.

1989 • 194 citations

Involvement of CPP32/Yama(-like) proteases in Fas-mediated apoptosis.

1996 • 165 citations

Actin is cleaved during constitutive apoptosis

1997 • 149 citations

Delayed Retraction of Filopodia in Gelsolin Null Mice

1997 • 145 citations

Inhibition of apoptosis by the actin-regulatory protein gelsolin

1997 • 141 citations

Immune and inflammatory mechanisms in the development of atherosclerosis

1993 • 139 citations

DNA fragmentation during apoptosis is caused by frequent single-strand cuts

1993 • 129 citations

Modulation of gelsolin function. Activation at low pH overrides Ca2+ requirement.

1993 • 114 citations

Distribution of cell replication and apoptosis in atherosclerotic plaques of cholesterol-fed rabbits

1996 • 111 citations

Isolation and properties of two actin-binding domains in gelsolin.

1985 • 105 citations

Association of profilin with filament-free regions of human leukocyte and platelet membranes and reversible membrane binding during platelet activation.

1989 • 94 citations

Cytochalasin B induces cellular DNA fragmentation

1990 • 93 citations

Apoptotic death of human leukemic cells induced by vascular cells expressing nitric oxide synthase in response to gamma-interferon and tumor necrosis factor-alpha.

1996 • 89 citations

Regulation of programmed cell death or apoptosis in atherosclerosis.

1997 • 43 citations

Gelsolin Activates DNase Iin Vitroand in Cystic Fibrosis Sputum

1997 • 38 citations

pH-dependent rate of formation of the gelsolin-actin complex from gelsolin and monomeric actin

1987 • 35 citations

Modulation of gelsolin content in rat aortic smooth muscle cells during development, experimental intimal thickening and culture

1990 • 25 citations