Crystal Structure of T7 Gene 4 Ring Helicase Indicates a Mechanism for Sequential Hydrolysis of Nucleotides

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

Structure at 2.8 Â resolution of F1-ATPase from bovine heart mitochondria

1994 • 2,954 citations

[27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods

1997 • 1,905 citations

A rapid finite difference algorithm, utilizing successive over‐relaxation to solve the Poisson–Boltzmann equation

1991 • 1,257 citations

The binding change mechanism for ATP synthase — Some probabilities and possibilities

1993 • 1,006 citations

Crystal Structures of Complexes of PcrA DNA Helicase with a DNA Substrate Indicate an Inchworm Mechanism

1999 • 793 citations

MECHANISMS OF HELICASE-CATALYZED DNA UNWINDING

1996 • 740 citations

The structure of the E. coli recA protein monomer and polymer

1992 • 738 citations

Structure of the recA protein–ADP complex

1992 • 617 citations

Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding

1998 • 613 citations

Major Domain Swiveling Revealed by the Crystal Structures of Complexes of E. coli Rep Helicase Bound to Single-Stranded DNA and ADP

1997 • 490 citations

Crystal structure of a DExx box DNA helicase

1996 • 428 citations

Crystal Structure of the Helicase Domain from the Replicative Helicase-Primase of Bacteriophage T7

1999 • 280 citations

Bacteriophage T7 helicase/primase proteins form rings around single-stranded DNA that suggest a general structure for hexameric helicases.

1995 • 256 citations

The crystal structure of the nucleotide-free α3β3 subcomplex of F1-ATPase from the thermophilic Bacillus PS3 is a symmetric trimer

1997 • 227 citations

Demonstration of Unidirectional Single-Stranded DNA Translocation by PcrA Helicase: Measurement of Step Size and Translocation Speed

1999 • 217 citations

Enzyme-catalyzed DNA unwinding: Studies on Escherichia coli rep protein

1979 • 198 citations

Helicases: a unifying structural theme?

1998 • 162 citations

DNA-dependent nucleoside 5'-triphosphatase activity of the gene 4 protein of bacteriophage T7.

1983 • 151 citations

Oligomeric structure of Escherichia coli primary replicative helicase DnaB protein.

1994 • 138 citations

The HexamericE. coliDnaB Helicase can Exist in Different Quarternary States

1996 • 137 citations

Signal transduction via Ras.

1998 • 122 citations

Oligomeric structure of bacteriophage T7 DNA primase/helicase proteins

1993 • 118 citations

Asymmetric Interactions of Hexameric Bacteriophage T7 DNA Helicase with the 5′- and 3′-Tails of the Forked DNA Substrate

1997 • 112 citations

Structure and assembly of the Escherichia coli transcription termination factor rho and its interactions with RNA I. Cryoelectron microscopic studies

1991 • 111 citations

DNA binding mediates conformational changes and metal ion coordination in the active site of PcrA helicase 1 1Edited by A. R. Fersht

1999 • 110 citations

Interactions of bacteriophage T7 DNA primase/helicase protein with single-stranded and double-stranded DNAs

1993 • 108 citations

Biochemical Analysis of Mutant T7 Primase/Helicase Proteins Defective in DNA Binding, Nucleotide Hydrolysis, and the Coupling of Hydrolysis with DNA Unwinding

1996 • 103 citations

Site-directed mutagenesis of motif III in PcrA helicase reveals a role in coupling ATP hydrolysis to strand separation

1999 • 93 citations

The Linker Region between the Helicase and Primase Domains of the Bacteriophage T7 Gene 4 Protein Is Critical for Hexamer Formation

1999 • 90 citations

Crystal structure of the N-terminal domain of the DnaB hexameric helicase

1999 • 86 citations

The dTTPase mechanism of T7 DNA helicase resembles the binding change mechanism of the F ₁ -ATPase

1997 • 85 citations

Negative cooperativity in the binding of nucleotides to Escherichia coli replicative helicase DnaB protein. Interactions with fluorescent nucleotide analogs

1993 • 80 citations

Binding of Escherichia coli Primary Replicative Helicase DnaB Protein to Single-Stranded DNA. Long-Range Allosteric Conformational Changes within the Protein Hexamer^,

1996 • 77 citations

A Domain of the Gene 4 Helicase/Primase of Bacteriophage T7 Required for the Formation of an Active Hexamer

1995 • 76 citations

Escherichia coli transcription termination protein rho has three hydrolytic sites for ATP.

1988 • 75 citations

Three-dimensional reconstructions from cryoelectron microscopy images reveal an intimate complex between helicase DnaB and its loading partner DnaC

1998 • 72 citations

Cooperative Interactions of Nucleotide Ligands Are Linked to Oligomerization and DNA Binding in Bacteriophage T7 Gene 4 Helicases

1996 • 70 citations

An N-terminal fragment of the gene 4 helicase/primase of bacteriophage T7 retains primase activity in the absence of helicase activity

1998 • 67 citations

The nucleotide binding site of the helicase/primase of bacteriophage T7. Interaction of mutant and wild-type proteins.

1993 • 64 citations

The K318A Mutant of Bacteriophage T7 DNA Primase-Helicase Protein Is Deficient in Helicase But Not Primase Activity and Inhibits Primase-Helicase Protein Wild-Type Activities by Heterooligomer Formation

1994 • 60 citations

Observations on the structure of the termination factor rho and its attachment to DNA

1972 • 60 citations

Characterization and crystallization of the helicase domain of bacteriophage T7 gene 4 protein

1997 • 57 citations

Bacteriophage T7 DNA Helicase Binds dTTP, Forms Hexamers, and Binds DNA in the Absence of Mg2+

1998 • 52 citations

Sequential Hydrolysis of ATP Molecules Bound in Interacting Catalytic Sites of Escherichia coli Transcription Termination Protein Rho

1998 • 50 citations

DnaB from Thermus aquaticus Unwinds Forked Duplex DNA with an Asymmetric Tail Length Dependence

1999 • 35 citations

Observations on the Structure of Spores

1975 • 30 citations

Transcription Termination Factor Rho Contains Three Noncatalytic Nucleotide Binding Sites

1999 • 26 citations

Demonstration of unidirectional single-stranded DNA translocation by PcrA helicase

2000 • 7 citations