Unfolding and internalization of proteins by the ATP-dependent proteases ClpXP and ClpAP

The Hsp70 and Hsp60 Chaperone Machines

1998 • 2,793 citations

AAA⁺: A Class of Chaperone-Like ATPases Associated with the Assembly, Operation, and Disassembly of Protein Complexes

1999 • 1,793 citations

Crystal Structure of the 20 S Proteasome from the Archaeon T. acidophilum at 3.4 Å Resolution

1995 • 1,513 citations

Role of a Peptide Tagging System in Degradation of Proteins Synthesized from Damaged Messenger RNA

1996 • 1,103 citations

The ClpXP and ClpAP proteases degrade proteins with carboxy-terminal peptide tails added by the SsrA-tagging system

1998 • 829 citations

HSP100/Clp proteins: a common mechanism explains diverse functions

1996 • 653 citations

Residues in chaperonin GroEL required for polypeptide binding and release

1994 • 645 citations

The Structure of ClpP at 2.3 Å Resolution Suggests a Model for ATP-Dependent Proteolysis

1997 • 603 citations

An Escherichia coli chromosomal "addiction module" regulated by guanosine [corrected] 3',5'-bispyrophosphate: a model for programmed bacterial cell death.

1996 • 586 citations

Protein quality control: triage by chaperones and proteases.

1997 • 543 citations

The N-End Rule in Bacteria

1991 • 536 citations

Global unfolding of a substrate protein by the Hsp100 chaperone ClpA

1999 • 427 citations

Dynamics of Substrate Denaturation and Translocation by the ClpXP Degradation Machine

2000 • 336 citations

Regulation of Escherichia coli starvation sigma factor (sigma s) by ClpXP protease

1996 • 323 citations

ClpX, an alternative subunit for the ATP-dependent Clp protease of Escherichia coli. Sequence and in vivo activities.

1993 • 317 citations

Enzymatic and Structural Similarities between theEscherichia coli ATP-dependent Proteases, ClpXP and ClpAP

1998 • 280 citations

Disassembly of the Mu transposase tetramer by the ClpX chaperone.

1995 • 276 citations

Degradation of carboxy-terminal-tagged cytoplasmic proteins by the Escherichia coli protease HflB (FtsH)

1998 • 268 citations

The ClpX heat-shock protein of Escherichia coli, the ATP-dependent substrate specificity component of the ClpP-ClpX protease, is a novel molecular chaperone.

1995 • 247 citations

Isolation and characterization of ClpX, a new ATP-dependent specificity component of the Clp protease of Escherichia coli.

1993 • 247 citations

SsrA-mediated peptide tagging caused by rare codons and tRNA scarcity

1999 • 227 citations

Self-compartmentalizing proteases

1997 • 216 citations

A multiple-component, ATP-dependent protease from Escherichia coli.

1987 • 213 citations

Addiction protein Phd of plasmid prophage P1 is a substrate of the ClpXP serine protease of Escherichia coli.

1995 • 188 citations

Regulatory Subunits of Energy-Dependent Proteases

1997 • 169 citations

Activity and specificity of Escherichia coli ClpAP protease in cleaving model peptide substrates.

1994 • 162 citations

[23] Endopeptidase Clp: ATP-dependent Clp protease from Escherichia coli

1994 • 156 citations

Protein binding and unfolding by the chaperone ClpA and degradation by the protease ClpAP

2000 • 154 citations

At Sixes and Sevens: Characterization of the Symmetry Mismatch of the ClpAP Chaperone-Assisted Protease

1998 • 140 citations

The role of the ClpA chaperone in proteolysis by ClpAP

1998 • 137 citations

ClpX and MuB interact with overlapping regions of Mu transposase: implications for control of the transposition pathway.

1997 • 129 citations

PDZ-like Domains Mediate Binding Specificity in the Clp/Hsp100 Family of Chaperones and Protease Regulatory Subunits

1997 • 108 citations

Recognition, Targeting, and Hydrolysis of the λ O Replication Protein by the ClpP/ClpX Protease

1999 • 88 citations

Mechanism of protein remodeling by ClpA chaperone

1997 • 84 citations

Mutational analysis demonstrates different functional roles for the two ATP-binding sites in ClpAP protease from Escherichia coli.

1994 • 81 citations

Structure and mechanism of ATP-dependent proteases

1999 • 73 citations

Versatile Action of Escherichia coli ClpXP as Protease or Molecular Chaperone for Bacteriophage Mu Transposition

1998 • 62 citations

ClpA and ClpP Remain Associated during Multiple Rounds of ATP-Dependent Protein Degradation by ClpAP Protease

1999 • 61 citations

Concurrent Chaperone and Protease Activities of ClpAP and the Requirement for the N-terminal ClpA ATP Binding Site for Chaperone Activity

1999 • 54 citations

Selective, Energy-dependent Proteolysis in Escherichia coli

1995 • 26 citations