Proteolysis and the biochemistry of life-or-death decisions.

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

1995 • 2,767 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

1994 • 994 citations

Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen

1994 • 941 citations

Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease.

1995 • 767 citations

Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death.

1996 • 621 citations

DNA-Dependent Kinase (p350) as a Candidate Gene for the Murine SCID Defect

1995 • 610 citations

Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia.

1995 • 549 citations

Absence of p350 Subunit of DNA-Activated Protein Kinase from a Radiosensitive Human Cell Line

1995 • 530 citations

Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death.

1994 • 424 citations

DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis.

1995 • 422 citations

Ataxia-telangiectasia and cellular responses to DNA damage.

1995 • 378 citations

Growth factor modulation of p53-mediated growth arrest versus apoptosis.

1995 • 377 citations

The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains.

1994 • 351 citations

Apoptosis and the cell cycle

1995 • 334 citations

Cleavage of actin by interleukin 1 beta-converting enzyme to reverse DNase I inhibition.

1996 • 298 citations

Isolation of cDNA clones encoding a human apurini/apyrimidinic endonuclease that corects DNA repair and mutagenisis defects inE.coli xth(exonuclease III) mutants

1991 • 294 citations

How can cryptic epitopes trigger autoimmunity?

1995 • 254 citations

Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM

1995 • 253 citations

DNA damage and the DNA-activated protein kinase

1993 • 237 citations

Structure and function of poly(ADP-ribose) polymerase

1994 • 206 citations

A dominant-negative mutant of human poly(ADP-ribose) polymerase affects cell recovery, apoptosis, and sister chromatid exchange following DNA damage.

1995 • 200 citations

Involvement of NAD-poly(ADP-ribose) metabolism in p53 regulation and its consequences.

1995 • 148 citations

Purification of an Interleukin-1β Converting Enzyme-related Cysteine Protease That Cleaves Sterol Regulatory Element-binding Proteins between the Leucine Zipper and Transmembrane Domains

1995 • 135 citations

Degradation of nuclear matrix and DNA cleavage in apoptotic thymocytes

1996 • 119 citations

Life and death by P53

1995 • 111 citations

Role of proteolysis in apoptosis: involvement of serine proteases in internucleosomal DNA fragmentation in immature thymocytes

1993 • 109 citations

Dissection of the genetic programs of p53-mediated G1 growth arrest and apoptosis: blocking p53-induced apoptosis unmasks G1 arrest

1995 • 100 citations

Stopped for repairs

1995 • 73 citations

Induction of p53 protein by gamma radiation in lymphocyte lines from breast cancer and ataxia telangiectasia patients

1995 • 19 citations