Degradation of nuclear matrix and DNA cleavage in apoptotic thymocytes

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1993 • 1,888 citations

Programmed cell death involved in the schizolysigenous formation of the secretory cavity in Citrus sinensis L. (Osbeck)

2010 • 1,629 citations

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

1994 • 1,239 citations

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.

1989 • 937 citations

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1994 • 843 citations

Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis

1995 • 834 citations

Prevention of Vertebrate Neuronal Death by the crmA Gene

1994 • 618 citations

Fas- and Tumor Necrosis Factor-induced Apoptosis Is Inhibited by the Poxvirus crmA Gene Product

1995 • 604 citations

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.

1994 • 596 citations

Functional Organization Of The Nuclear Envelope

1988 • 593 citations

Premature p34 ^cdc2 Activation Required for Apoptosis

1994 • 568 citations

Fluorescein isothiocyanate-labeled casein assay for proteolytic enzymes

1984 • 555 citations

Nuclear changes in apoptosis

1995 • 538 citations

Monoclonal antibodies identify a group of nuclear pore complex glycoproteins.

1987 • 533 citations

Role of Chromosome Territories in the Functional Compartmentalization of the Cell Nucleus

1993 • 504 citations

Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis.

1993 • 452 citations

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions.

1992 • 447 citations

Calpain activation in apoptosis

1994 • 445 citations

Core filaments of the nuclear matrix.

1990 • 436 citations

Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death.

1994 • 424 citations

Topoisomerase II-reactive chemotherapeutic drugs induce apoptosis in thymocytes.

1991 • 392 citations

A natural killer cell granule protein that induces DNA fragmentation and apoptosis.

1992 • 379 citations

The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA.

1989 • 367 citations

Inhibition of proteolysis protects hippocampal neurons from ischemia.

1991 • 363 citations

Phosphorylation of the nuclear lamins during interphase and mitosis.

1985 • 354 citations

Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase.

1994 • 345 citations

Binding of matrix attachment regions to lamin B1

1992 • 318 citations

Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain

1994 • 314 citations

Lamin B constitutes an intermediate filament attachment site at the nuclear envelope.

1987 • 306 citations

Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A

1992 • 243 citations

Degradation of lamin B1 precedes oligonucleosomal DNA fragmentation in apoptotic thymocytes and isolated thymocyte nuclei.

1995 • 242 citations

Human-specific nuclear protein that associates with the polar region of the mitotic apparatus: Distribution in a human/hamster hybrid cell

1980 • 236 citations

NuMA: an unusually long coiled-coil related protein in the mammalian nucleus.

1992 • 231 citations

Detection of the initial stages of DNA fragmentation in apoptosis.

1993 • 228 citations

Genome digestion is a dispensable consequence of physiological cell death mediated by cytotoxic T lymphocytes.

1992 • 225 citations

Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis.

1992 • 215 citations

NuMA is required for the proper completion of mitosis.

1993 • 207 citations

Interphase nuclear envelope lamins form a discontinuous network that interacts with only a fraction of the chromatin in the nuclear periphery

1990 • 197 citations

Expression of chicken lamin B2 in Escherichia coli: characterization of its structure, assembly, and molecular interactions.

1991 • 176 citations

Changes in distribution of nuclear matrix antigens during the mitotic cell cycle.

1984 • 159 citations

Diagnostic Electron Microscopy

1979 • 142 citations

Identification of protein kinase C (PKC) phosphorylation sites on human lamin B. Potential role of PKC in nuclear lamina structural dynamics.

1993 • 139 citations

A complex containing p34cdc2 and cyclin B phosphorylates the nuclear lamin and disassembles nuclei of clam oocytes in vitro.

1991 • 133 citations

Activation of intracellular proteases is an early event in TNF-induced apoptosis.

1995 • 129 citations

Ubiquitin pathway involvement in human lymphocyte gamma-irradiation-induced apoptosis.

1993 • 124 citations

Role of proteolysis in apoptosis: involvement of serine proteases in internucleosomal DNA fragmentation in immature thymocytes

1993 • 109 citations

A role for the p34cdc2 kinase and phosphatases in the regulation of phosphorylation and disassembly of lamin B2 during the cell cycle.

1991 • 108 citations

Mutation of the predicted p34cdc2 phosphorylation sites in numa impair the assembly of the mitotic spindle and block mitosis

1995 • 103 citations

Aggregation of vasopressin mRNA in a subset of axonal swellings of the median eminence and posterior pituitary: light and electron microscopic evidence

1994 • 102 citations

Lamin B is rapidly phosphorylated in lymphocytes after activation of protein kinase C.

1988 • 101 citations

Localization of NuMA protein isoforms in the nuclear matrix of mammalian cells

1994 • 101 citations

The topoisomerase II inhibitor teniposide (VM-26) induces apoptosis in unstimulated mature murine lymphocytes

1992 • 95 citations

Endonuclease activities, chromatin structure, and DNA degradation in apoptosis

1994 • 94 citations

A human T lymphoblastic cell line lacks lamins A and C.

1987 • 93 citations

Redistribution of the nuclear mitotic apparatus protein (NuMA) during mitosis and nuclear assembly

1986 • 79 citations

Apoptosis of rat thymocytes triggered by prednisolone, camptothecin, or teniposide is selective to G0 cells and is prevented by inhibitors of proteases.

1992 • 75 citations

Cathepsin B, a Cysteine Protease Implicated in Metastatic Progression, is also Expressed During Regression of the Rat Prostate and Mammary Glands

1994 • 71 citations

Degradation of chromatin in apoptotic cells.

1995 • 69 citations

Involvement of a serine protease in tumour‐necrosis‐factor‐mediated cytotoxicity

1988 • 65 citations

NuMA: a protein involved in nuclear structure, spindle assembly, and nuclear re-formation

1995 • 64 citations

Glucocorticoid-induced cell-size changes and nuclear fragility in rat thymocytes

1981 • 63 citations

Destruction of the nuclear morphology of thymic lymphocytes by the corticosteroid cortisol

1968 • 48 citations

Glucocorticoids Stimulate Protein Degradation in Lymphocytes: A Possible Mechanism of Steroid-Induced Cell Death*

1980 • 43 citations

Nuclear envelope structure

1992 • 42 citations

DNA Fragmentation Induced by Cytotoxic T Lymphocytes Can Result in Target Cell Death

1993 • 30 citations

Altered protein binding to the octamer motif appears to be an early event in programmed neuronal cell death.

1993 • 20 citations

Ultrastructural localization of nuclear antigens during interphase in mouse 3T3 fibroblasts

1989 • 12 citations

Gamma Irradiation or Hydrocortisone Treatment of Rats Increases the Proteinase Activity Associated with Histones of Thymus Nuclei

1994 • 11 citations

Induction of cell surface peptidase activity: A global response to cell stress correlated with apoptosis

1994 • 9 citations

Degradation of constitutive transcription factors during apoptosis in rat thymocytes

1994 • 6 citations