The effects of bosentan, aminoguanidine and l-canavanine on mesenteric blood flow, spleen and liver in endotoxaemic mice

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

1995 • 1,454 citations

1400W Is a Slow, Tight Binding, and Highly Selective Inhibitor of Inducible Nitric-oxide Synthase in Vitro and in Vivo

1997 • 828 citations

Molecular mechanisms and therapeutic strategies related to nitric oxide

1995 • 791 citations

Selective inhibition of the inducible nitric oxide synthase by aminoguanidine

1993 • 734 citations

Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst.

1987 • 678 citations

Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist.

1994 • 650 citations

Induction and potential biological relevance of a Ca²⁺‐independent nitric oxide synthase in the myocardium

1992 • 623 citations

Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo

1990 • 536 citations

Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway

1990 • 462 citations

Role of nitric oxide in maintaining vascular integrity in endotoxin‐induced acute intestinal damage in the rat

1990 • 369 citations

Nitric oxide and septic shock

1997 • 309 citations

NO, nitrosonium ions, nitroxide ions, nitrosothiols and iron-nitrosyls in biology: a chemist's perspective

1995 • 301 citations

Endotoxin stimulates endothelin-release in vivo and in vitro as determined by radioimmunoassay

1989 • 265 citations

Determinants of splanchnic blood flow

1996 • 239 citations

Elevated Plasma Endothelin-1 Concentrations Are Associated with the Severity of Illness in Patients with Sepsis

1991 • 227 citations

The multiple organ dysfunction syndrome caused by endotoxin in the rat: attenuation of liver dysfunction by inhibitors of nitric oxide synthase

1995 • 219 citations

Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotoxic shock

1995 • 211 citations

Elevated plasma levels of endothelin in patients with sepsis syndrome.

1991 • 137 citations

Time‐dependent enhancement or inhibition of endotoxin‐induced vascular injury in rat intestine by nitric oxide synthase inhibitors

1994 • 137 citations

Distribution and properties of human intestinal diamine oxidase and its relevance for the histamine catabolism

1983 • 131 citations

Endotoxin-induced organ injury

1993 • 131 citations

Aminoguanidine: A drug proposed for prophylaxis in diabetes inhibits catalase and generates hydrogen peroxide in vitro

1993 • 116 citations

Aminoguanidine inhibits oxidative modification of low density lipoprotein protein and the subsequent increase in uptake by macrophage scavenger receptors.

1992 • 110 citations

The influence of catabolic reactions on polyamine excretion

1985 • 110 citations

The Cardiovascular Pathophysiology of Sepsis

1989 • 105 citations

Comparison of the effects of aminoguanidine and Nω-nitro-l-arginine methyl ester on the multiple organ dysfunction caused by endotoxaemia in the rat

1996 • 74 citations

Bosentan‐improved cardiopulmonary vascular performance and increased plasma levels of endothelin‐1 in porcine endotoxin shock

1996 • 68 citations

Modulation of Circulating Endothelin Levels in Hypertension and Endotoxemia in Rats

1991 • 63 citations

HEPATOCELLULAR DYSFUNCTION OCCURS EARLIER THAN THE ONSET OF HYPERDYNAMIC CIRCULATION DURING SEPSIS

1995 • 60 citations

Beneficial Effects of L-Canavanine, a Selective Inhibitor of Inducible Nitric Oxide Synthase, during Rodent Endotoxaemia

1996 • 49 citations

Endotoxin‐induced impairment of vasopressor and vasodepressor responses in the pithed rat

1990 • 47 citations

Nitric oxide. A key mediator in sepsis and endotoxaemia?

1997 • 45 citations

Effect of selective blockade of endothelin ET_B receptors on the liver dysfunction and injury caused by endotoxaemia in the rat

1996 • 44 citations

Enhancement of the hypotensive and vasodilator effects of endotoxaemia in conscious rats by the endothelin antagonist, SB 209670

1995 • 39 citations

Hyporeactivity of mesenteric vascular bed in endotoxin-treated rats

1996 • 37 citations

Untitled

1998 • 24 citations

Evidence that aminoguanidine inhibits endotoxin-induced bacterial translocation

1998 • 22 citations

Untitled

1998 • 14 citations

Nitric Oxide Donors in Endotoxic and Septic Shock: Evidence Against Nitric Oxide as a Mediator of Shock.

1998 • 8 citations