Bosentan‐improved cardiopulmonary vascular performance and increased plasma levels of endothelin‐1 in porcine endotoxin shock

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Cloning and expression of a cDNA encoding an endothelin receptor

1990 • 2,590 citations

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

1990 • 2,432 citations

Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

1988 • 1,417 citations

The Pathogenesis of Sepsis

1991 • 1,376 citations

Increased Plasma Endothelin-1 in Pulmonary Hypertension: Marker or Mediator of Disease?

1991 • 983 citations

Circulating and Tissue Endothelin Immunoreactivity in Advanced Atherosclerosis

1991 • 967 citations

Antibodies to Bradykinin and Angiotensin: A Use of Carbodiimides in Immunology

1964 • 820 citations

Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist.

1994 • 650 citations

Contribution of endogenous generation of endothelin-1 to basal vascular tone

1994 • 588 citations

Adult Respiratory-Distress Syndrome

1982 • 554 citations

Mesangial cell, glomerular and renal vascular responses to endothelin in the rat kidney. Elucidation of signal transduction pathways.

1989 • 413 citations

The endothelin ETB receptor mediates both vasodilation and vasoconstriction in vivo

1992 • 405 citations

Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium‐derived vasoconstrictor peptide, endothelin: Identity of human and porcine endothelin

1988 • 400 citations

Glomerular actions of endothelin in vivo.

1989 • 351 citations

Immunoreactive endothelin in human plasma: Marked elevations in patients in cardiogenic shock

1989 • 330 citations

Stimulation of endothelin mRNA and secretion in rat vascular smooth muscle cells: a novel autocrine function.

1990 • 271 citations

Endotoxin stimulates endothelin-release in vivo and in vitro as determined by radioimmunoassay

1989 • 265 citations

Venous smooth muscle contains vasoconstrictor ETB-like receptors

1992 • 258 citations

Septic shock. Hemodynamics and pathogenesis.

1983 • 229 citations

Prostaglandin E1 and Nitroglycerin Reduce Pulmonary Capillary Pressure but Worsen Ventilation—Perfusion Distributions in Patients with Adult Respiratory Distress Syndrome

1989 • 173 citations

Septic Shock

1983 • 155 citations

[63] Catecholamine measurements in plasma by high-performance liquid chromatography with electrochemical detection

1987 • 150 citations

Elevated plasma levels of endothelin in patients with sepsis syndrome.

1991 • 137 citations

Novel ligands BQ123 and BQ3020 characterize endothelin receptor subtypes ETA and ETB in human kidney

1993 • 135 citations

Effect of different endothelin receptor antagonists and of the novel non‐peptide antagonist Ro 46‐2005 on endothelin levels in rat plasma

1993 • 122 citations

Cytokine-induced release of endothelin-1 from porcine renal epithelial cell line

1990 • 122 citations

Endothelin-1 inhibits AVP-stimulated osmotic water permeability in rat inner medullary collecting duct

1991 • 120 citations

Tissue specific distribution, clearance and vascular effects of endothelin in the pig

1989 • 110 citations

Why are circulating concentrations of endothelin-1 so low?

1994 • 106 citations

Production of Endothelin-1 in Vascular Endothelial Cells Is Regulated by Factors Associated with Vascular Injury

1992 • 98 citations

Nitric oxide inhalation attenuates pulmonary hypertension and improves gas exchange in endotoxin shock

1993 • 86 citations

Direct effects of endothelin in the rat kidney

1990 • 85 citations

Prostacyclin and right ventricular function in patients with pulmonary hypertension associated with ARDS

1990 • 81 citations

Long-lasting vasoconstriction and efficient regional extraction of endothelin-1 in human splanchnic and renal tissues

1991 • 76 citations

Acute respiratory failure

1986 • 73 citations

Differences in vascular effects and removal of endothelin‐1 in human lung, brain, and skeletal muscle,

1993 • 72 citations

Biochemical and functional characterization of endothelin peptides with special reference to vascular effects.

1991 • 68 citations

Pulmonary circulation during adult respiratory distress syndrome

1985 • 55 citations

Increased plasma levels of endothelin‐like immunoreactivity during endotoxin administration in the pig

1989 • 54 citations

The endothelin receptor antagonist, bosentan, in combination with the cyclooxygenase inhibitor, diclofenac, counteracts pulmonary hypertension in porcine endotoxin shock

1997 • 45 citations

Effects of bosentan (Ro 47–0203), an ET_A‐, ET_B‐receptor antagonist, on regional haemodynamic responses to endothelins in conscious rats

1994 • 44 citations

Effect of longstanding venous stasis and hypoproteinaemia on lymph flow in the rat tail

1991 • 38 citations

Ibuprofen attenuates plasma tumor necrosis factor activity during sepsis-induced acute lung injury

1991 • 33 citations

Inhibitory effects of diclofenac on the endotoxin shock response in relation to endothelin turnover in the pig

1995 • 28 citations

Prostaglandin and thromboxane levels during endotoxin-induced respiratory failure in pigs

1987 • 21 citations

Porcine intrinsic pulmonary and systemic vascular tone is endothelin‐dependent

1994 • 18 citations

Thromboxane A2-Receptor Blockade and Prostacyclin in Porcine Escherichia coli Shock

1989 • 16 citations

INTERACTION BETWEEN VASOPRESSIN AND ENDOTHELIN IN RENAL PAPILLARY TUBULES: UNCOUPLING FOLLOWING CELL ISOLATION AND CULTURE

1992 • 4 citations