Induction of autoantibody production but not autoimmune disease in HEL transgenic mice vaccinated with HEL in combination with CpG or control oligodeoxynucleotides

CpG motifs in bacterial DNA trigger direct B-cell activation

1995 • 3,543 citations

CpG Motifs in Bacterial DNA and Their Immune Effects

2002 • 2,520 citations

Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

2002 • 1,877 citations

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

1988 • 1,562 citations

Natural selection of tumor variants in the generation of “tumor escape” phenotypes

2002 • 1,014 citations

CpG Oligodeoxynucleotides Act as Adjuvants that Switch on T Helper 1 (Th1) Immunity

1997 • 1,008 citations

Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off

1998 • 989 citations

Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants

1997 • 919 citations

CpG DNA Is a Potent Enhancer of Specific Immunity in Mice Immunized with Recombinant Hepatitis B Surface Antigen

1998 • 684 citations

Delineation of a CpG Phosphorothioate Oligodeoxynucleotide for Activating Primate Immune Responses In Vitro and In Vivo

2000 • 593 citations

Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization

1997 • 526 citations

Induction of self-tolerance in mature peripheral B lymphocytes

1989 • 525 citations

Antitumor Activity of Deoxyribonucleic Acid Fraction From <italic>Mycobacterium bovis</italic> BCG. I. Isolation, Physicochemical Characterization, and Antitumor Activity<xref ref-type="fn" rid="FN2">2</xref>

1984 • 471 citations

CpG‐containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants

1997 • 390 citations

CpG DNA Induces Sustained IL-12 Expression In Vivo and Resistance toListeria monocytogenesChallenge

1998 • 383 citations

Different Nuclear Signals Are Activated by the B Cell Receptor during Positive Versus Negative Signaling

1997 • 383 citations

Bacterial DNA Containing CpG Motifs Stimulates Lymphocyte-Dependent Protection of Mice Against Lethal Infection with Intracellular Bacteria

1999 • 322 citations

Antigen-induced regulatory T cells in autoimmunity

2003 • 317 citations

CpG motifs: the active ingredient in bacterial extracts?

2003 • 280 citations

CpG DNA induces stronger immune responses with less toxicity than other adjuvants

2000 • 264 citations

A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant

2003 • 255 citations

Breakdown of self-tolerance in anergic B lymphocytes

1991 • 254 citations

Divergent Therapeutic and Immunologic Effects of Oligodeoxynucleotides with Distinct CpG Motifs

2001 • 252 citations

The fate of self-reactive B cells depends primarily on the degree of antigen receptor engagement and availability of T cell help.

1996 • 251 citations

Tolerance to a self-protein involves its immunodominant but does not involve its subdominant determinants.

1992 • 219 citations

NK- and CD8+ T Cell-Mediated Eradication of Established Tumors by Peritumoral Injection of CpG-Containing Oligodeoxynucleotides

2001 • 213 citations

CpG DNA overcomes hyporesponsiveness to hepatitis B vaccine in orangutans

2000 • 191 citations

Oligodeoxynucleotides containing CpG motifs can induce rejection of a neuroblastoma in mice.

1999 • 188 citations

Resistance to CpG DNA–induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling

2003 • 184 citations

A Range of CD4 T Cell Tolerance: Partial Inactivation to Organ-Specific Antigen Allows Nondestructive Thyroiditis or Insulitis

1997 • 178 citations

CpG DNA: A pathogenic factor in systemic lupus erythematosus?

1995 • 162 citations

Oral, intrarectal and intranasal immunizations using CpG and non-CpG oligodeoxynucleotides as adjuvants

2000 • 160 citations

CpG Are Efficient Adjuvants for Specific CTL Induction Against Tumor Antigen-Derived Peptide

2002 • 148 citations

Repeated Administration of Cytosine-Phosphorothiolated Guanine-Containing Oligonucleotides Together with Peptide/Protein Immunization Results in Enhanced CTL Responses with Anti-Tumor Activity

2000 • 145 citations

Successful treatment of intracranial gliomas in rat by oligodeoxynucleotides containing CpG motifs.

2000 • 135 citations

Immunostimulatory CpG Oligodeoxynucleotides Enhance the Immune Response to Vaccine Strategies Involving Granulocyte-Macrophage Colony-Stimulating Factor

1998 • 124 citations

Combined dendritic cell- and CpG oligonucleotide-based immune therapy cures large murine tumors that resist chemotherapy

2002 • 118 citations

A role for Toll in autoimmunity

2002 • 82 citations

Parenteral and mucosal prime-boost immunization strategies in mice with hepatitis B surface antigen and CpG DNA

2002 • 80 citations

Breaking tolerance leads to autoantibody production but not autoimmune liver disease in hepatitis B virus envelope transgenic mice.

1995 • 80 citations

IL-1 Receptor-Associated Kinase 1 Regulates Susceptibility to Organ-Specific Autoimmunity

2003 • 77 citations

Vaccination with Tumor Peptide in CpG Adjuvant Protects Via IFN-γ-Dependent CD4 Cell Immunity

2002 • 69 citations

Antimetastatic effect of CpG DNA mediated by type I IFN.

2001 • 64 citations

CpG-ODN-induced inflammation is sufficient to cause T-cell-mediated autoaggression against hepatocytes

2002 • 62 citations

Immunostimulatory CpG Motifs Trigger a T Helper-1 Immune Response to Human Immunodeficiency Virus Type-1 (HIV-1) gp160 Envelope Proteins

1999 • 58 citations

CpG DNA as a Th1-promoting adjuvant in immunization against Trypanosoma cruzi

2000 • 56 citations

Bacterial motif DNA as an adjuvant for the breakdown of immune self-tolerance to pyruvate dehydrogenase complex

2002 • 49 citations

Synergy between CpG- or non-CpG DNA and specific antigen for B cell activation

2003 • 48 citations

Implication of macrophages in tumor rejection induced by CpG-oligodeoxynucleotides without antigen.

2001 • 47 citations

CpG oligodeoxynucleotide enhances immunity against blood-stage malaria infection in mice parenterally immunized with a yeast-expressed 19 kDa carboxyl-terminal fragment of Plasmodium yoelii merozoite surface protein-1 (MSP119) formulated in oil-based Montanides

2003 • 45 citations

Rescue of self-reactive B cells by provision of T cell helpin vivo

1998 • 43 citations

CpG Oligodeoxynucleotides with Hepatitis B Surface Antigen (HBsAg) for Vaccination in HBsAg-Transgenic Mice

2001 • 42 citations

Hen egg-white lysozyme-specific T cells elicited in hen egg-white lysozyme-transgenic mice retain an imprint of self-tolerance.

1993 • 35 citations

Oligodeoxynucleotides Without CpG Motifs Work as Adjuvant for the Induction of Th2 Differentiation in a Sequence-Independent Manner

2003 • 33 citations

Human immunodeficiency virus (HIV)-specific immune responses are generated with the simultaneous vaccination of a gp120-depleted, whole-killed HIV-1 immunogen with cytosine-phosphorothioate-guanine dinucleotide immunostimulatory sequences of DNA.

2001 • 25 citations

Whither the Anergic B-Cell?

1994 • 23 citations

Determinant Selection for T-Cell Tolerance in HEL-Transgenic Mice: Dissociation between Immunogenicity and Tolerogenicity

1997 • 17 citations

Breakdown of Tolerance to a Neo-Self Antigen in Double Transgenic Mice in Which B Cells Present the Antigen

2000 • 15 citations