CD4 regulatory T cells in human cancer pathogenesis

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

2016 • 29,943 citations

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Cancer immunoediting: from immunosurveillance to tumor escape

2002 • 4,911 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

2017 • 4,003 citations

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer

2003 • 3,194 citations

IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

2001 • 2,658 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

2005 • 2,256 citations

Regulatory T cells, tumour immunity and immunotherapy

2006 • 2,009 citations

Immunosuppressive networks in the tumour environment and their therapeutic relevance

2005 • 1,990 citations

CD4+CD25high Regulatory Cells in Human Peripheral Blood

2001 • 1,882 citations

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

2001 • 1,831 citations

Regulatory T Cells

2000 • 1,827 citations

A function for interleukin 2 in Foxp3-expressing regulatory T cells

2005 • 1,744 citations

Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

2003 • 1,564 citations

Prevalence of Regulatory T Cells Is Increased in Peripheral Blood and Tumor Microenvironment of Patients with Pancreas or Breast Adenocarcinoma

2002 • 1,454 citations

Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells

2003 • 1,252 citations

Role of LAG-3 in Regulatory T Cells

2004 • 1,198 citations

Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

2005 • 1,189 citations

Ex Vivo Isolation and Characterization of Cd4+Cd25+ T Cells with Regulatory Properties from Human Blood

2001 • 1,168 citations

Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer.

2001 • 1,126 citations

Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.

1999 • 1,066 citations

I<scp>nterleukin</scp>-10<scp>and</scp>R<scp>elated</scp>C<scp>ytokines and</scp>R<scp>eceptors</scp>

2004 • 1,063 citations

Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells

2005 • 998 citations

Human T Regulatory Cells Can Use the Perforin Pathway to Cause Autologous Target Cell Death

2004 • 972 citations

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3

2005 • 957 citations

FOXP3: Of Mice and Men

2005 • 929 citations

CTLA-4: new insights into its biological function and use in tumor immunotherapy

2002 • 923 citations

CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor–β–dependent manner

2005 • 889 citations

Unique Chemotactic Response Profile and Specific Expression of Chemokine Receptors Ccr4 and Ccr8 by Cd4+Cd25+ Regulatory T Cells

2001 • 888 citations

Inhibition of CD4+25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide

2005 • 878 citations

Induction and mechanism of action of transforming growth factor‐β‐secreting Th3 regulatory cells

2001 • 856 citations

Type 1 T regulatory cells

2001 • 829 citations

LAG-3, a novel lymphocyte activation gene closely related to CD4.

1990 • 802 citations

Randomised trial of basiliximab versus placebo for control of acute cellular rejection in renal allograft recipients

1997 • 757 citations

Foxp3 Expressing CD4+CD25high Regulatory T Cells Are Overrepresented in Human Metastatic Melanoma Lymph Nodes and Inhibit the Function of Infiltrating T Cells

2004 • 680 citations

TGF-β1 Plays an Important Role in the Mechanism of CD4+CD25+ Regulatory T Cell Activity in Both Humans and Mice

2004 • 643 citations

Central tolerance: learning self-control in the thymus

2005 • 641 citations

Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells.

1982 • 640 citations

Increased Populations of Regulatory T Cells in Peripheral Blood of Patients with Hepatocellular Carcinoma

2005 • 618 citations

Infectious Tolerance

2002 • 614 citations

Cutting Edge: IL-2 Is Critically Required for the In Vitro Activation of CD4+CD25+ T Cell Suppressor Function

2004 • 572 citations

Prognostic Value of Tumor-Infiltrating CD4+ T-Cell Subpopulations in Head and Neck Cancers

2006 • 561 citations

Concomitant Tumor Immunity to a Poorly Immunogenic Melanoma Is Prevented by Regulatory T Cells

2004 • 541 citations

Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma

2003 • 525 citations

Tumor-Specific Human CD4+ Regulatory T Cells and Their Ligands

2004 • 525 citations

Differentiation of T Regulatory Cells by Immature Dendritic Cells

2001 • 500 citations

Human CD4+CD25+ thymocytes and peripheral T cells have immune suppressive activityin vitro

2001 • 498 citations

The Expression of the Regulatory T Cell–Specific Forkhead Box Transcription Factor FoxP3 Is Associated with Poor Prognosis in Ovarian Cancer

2005 • 494 citations

Existent T-cell and antibody immunity to HER-2/neu protein in patients with breast cancer.

1994 • 467 citations

Clinical and biologic effects of anti-interleukin-10 monoclonal antibody administration in systemic lupus erythematosus

2000 • 464 citations

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells

2012 • 462 citations

Generation Ex Vivo of TGF-β-Producing Regulatory T Cells from CD4+CD25− Precursors

2002 • 461 citations

Outcome in Hodgkin's Lymphoma Can Be Predicted from the Presence of Accompanying Cytotoxic and Regulatory T Cells

2005 • 453 citations

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+regulatory T cells

2005 • 451 citations

Frontline: Neuropilin‐1: a surface marker of regulatory T cells

2004 • 447 citations

Breast and ovarian cancer-specific cytotoxic T lymphocytes recognize the same HER2/neu-derived peptide.

1995 • 446 citations

The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs

2005 • 439 citations

An X-linked syndrome of diarrhea, polyendocrinopathy, and fatal infection in infancy

1982 • 436 citations

Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance

2005 • 429 citations

Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors

2005 • 423 citations

Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma

2006 • 412 citations

Recruitment of latent pools of high-avidity CD8+ T cells to the antitumor immune response

2005 • 403 citations

Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes

2003 • 388 citations

Phenotype, Localization, and Mechanism of Suppression of CD4+CD25+ Human Thymocytes

2002 • 384 citations

Plasmacytoid Dendritic Cells Induce CD8+ Regulatory T Cells In Human Ovarian Carcinoma

2005 • 376 citations

Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens.

1992 • 366 citations

Current methods for attaching targeting ligands to liposomes and nanoparticles

2004 • 353 citations

Characterization of CD4⁺CD25⁺ Regulatory T Cells in Patients Treated With High-Dose Interleukin-2 for Metastatic Melanoma or Renal Cell Carcinoma

2006 • 348 citations

Analysis of the Cellular Mechanism of Antitumor Responses and Autoimmunity in Patients Treated with CTLA-4 Blockade

2005 • 331 citations

Regulation of immunity by self-reactive T cells

2005 • 306 citations

CD4(+)CD25high regulatory T cells increase with tumor stage in patients with gastric and esophageal cancers

2005 • 286 citations

Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell–driven B cell responses

2004 • 282 citations

Characteristics of CD4+CD25+ regulatory T cells in the peripheral circulation of patients with head and neck cancer

2005 • 271 citations

Compromised lymphocytes infiltrate hepatocellular carcinoma: The role of T-regulatory cells

2005 • 269 citations

Tumour lymphocytic infiltrate and recurrence of hepatocellular carcinoma following liver transplantation

2006 • 244 citations

Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell–driven B cell responses

2004 • 241 citations

Antigen-specific regulatory T cells—their induction and role in infection

2004 • 237 citations

A rare polyadenylation signal mutation of the FOXP3 gene (AAUAAA→AAUGAA) leads to the IPEX syndrome

2001 • 237 citations

Peripheral Tolerance of CD8 T Lymphocytes

2005 • 227 citations

Regulatory T cells: Development, function and role in autoimmunity

2005 • 222 citations

Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice.

2002 • 214 citations

CD4+ regulatory T cells: Mechanisms of induction and effector function

2005 • 205 citations

Do Suppressor T Cells Exist?

1988 • 201 citations

FOXP3 acts as a rheostat of the immune response

2005 • 201 citations

IPEX is a unique X-linked syndrome characterized by immune dysfunction, polyendocrinopathy, enteropathy, and a variety of autoimmune phenomena

2001 • 192 citations

Improved treatment response with basiliximab immunoprophylaxis after liver transplantation: Results from a double-blind randomized placebo-controlled trial

2002 • 185 citations

Thymic regulatory T cells

2005 • 181 citations

GITR: a multifaceted regulator of immunity belonging to the tumor necrosis factor receptor superfamily

2005 • 173 citations

Human CD25⁺ regulatory T cells: two subsets defined by the integrins α₄β₇ or α₄β₁ confer distinct suppressive properties upon CD4⁺ T helper cells

2004 • 172 citations

Type I Regulatory T Cells Specific for Desmoglein 3 Are More Frequently Detected in Healthy Individuals than in Patients with Pemphigus Vulgaris

2004 • 165 citations

Pre-existent immunity to the HER-2/neu oncogenic protein in patients with HER-2/neu overexpressing breast and ovarian cancer

2000 • 161 citations

IPEX and FOXP3: Clinical and research perspectives

2005 • 160 citations

LAG-3: a regulator of T-cell and DC responses and its use in therapeutic vaccination

2003 • 140 citations

Antigen-specific regulatory T cells—Ex vivo expansion and therapeutic potential

2006 • 136 citations

Antibody Immunity to the p53 Oncogenic Protein Is a Prognostic Indicator in Ovarian Cancer

2006 • 136 citations

Biodegradable Nanoparticles for Direct or Two-Step Tumor Immunotargeting

2005 • 133 citations

IL-2 Immunotoxin Therapy Modulates Tumor-Associated Regulatory T Cells and Leads to Lasting Immune-Mediated Rejection of Breast Cancers in neu-Transgenic Mice

2006 • 132 citations

Human CD4+CD25high Regulatory T Cells Modulate Myeloid but Not Plasmacytoid Dendritic Cells Activation

2006 • 121 citations

Regulatory T cells and cytokines in malignant pleural effusions secondary to mesothelioma and carcinoma

2005 • 120 citations

Immunologically mediated regression of a murine lymphoma after treatment with anti-L3T4 antibody. A consequence of removing L3T4+ suppressor T cells from a host generating predominantly Lyt-2+ T cell-mediated immunity.

1988 • 118 citations

Regulatory T Cells

2004 • 111 citations

Current status of interleukin-2 therapy for metastatic renal cell carcinoma and metastatic melanoma.

2002 • 109 citations

Mutational Analysis of the FOXP3 Gene and Evidence for Genetic Heterogeneity in the Immunodysregulation, Polyendocrinopathy, Enteropathy Syndrome

2003 • 107 citations

Immune responses to p53 in patients with cancer:enrichment in tetramer+ p53 peptide-specific T cells and regulatory T cells at tumor sites

2005 • 104 citations

Distribution of CD4(+)CD25high regulatory T-cells in tumor-draining lymph nodes in patients with gastric cancer

2004 • 102 citations

CD4+CD25+ regulatory T cells in the peripheral blood of patients with breast cancer and non-small cell lung cancer

2005 • 89 citations

CCR8 Is Expressed by Antigen-Elicited, IL-10-Producing CD4+CD25+ T Cells, Which Regulate Th2-Mediated Granuloma Formation in Mice

2005 • 88 citations

Regulatory T cells and tumor immunity

2005 • 85 citations

Regulating the immune system: the induction of regulatory T cells in the periphery.

2004 • 85 citations

Interferon-γ expression is an independent prognostic factor in ovarian cancer

2004 • 83 citations

CD4⁺CD25⁺‐Regulatory T Cells from Mouse to Man

2005 • 82 citations

CD4⁺CD25⁺Regulatory T Lymphocytes in Malignant Pleural Effusion

2005 • 75 citations

Selective Elimination of Human Regulatory T Lymphocytes In Vitro With the Recombinant Immunotoxin LMB-2

2006 • 75 citations

Maturation of dendritic cells and T‐cell responses in sentinel lymph nodes from patients with breast carcinoma

2006 • 73 citations

The paradox of T cell?mediated antitumor immunity in spite of poor clinical outcome in human melanoma

2004 • 70 citations

Human CD4+CD25+ regulatory T cells and infectious tolerance.

2004 • 69 citations

Expression of a Tolerizing Tumor Antigen in Peripheral Tissue Does Not Preclude Recovery of High-Affinity CD8+ T Cells or CTL Immunotherapy of Tumors Expressing the Antigen

2001 • 67 citations

Phenotyping of lymphocytes expressing regulatory and effector markers in infiltrating ductal carcinoma of the breast

2005 • 66 citations

Inhibition of the Transcription Factor Foxp3 Converts Desmoglein 3-Specific Type 1 Regulatory T Cells into Th2-Like Cells

2006 • 64 citations

Lymphocyte composition of tumor draining lymph nodes from cervical and endometrial cancer patients

2003 • 62 citations

Vaccine implications of folate binding protein, a novel cytotoxic T lymphocyte-recognized antigen system in epithelial cancers.

1999 • 59 citations

Complement-induced regulatory T cells suppress T-cell responses but allow for dendritic-cell maturation

2005 • 58 citations

The cDNA sequence of mouse LAMP-2. Evidence for two classes of lysosomal membrane glycoproteins.

1990 • 57 citations

Evaluation of pre-existent immunity in patients with primary breast cancer: molecular and cellular assays to quantify antigen-specific T lymphocytes in peripheral blood mononuclear cells.

2003 • 56 citations

Use of class II tetramers for identification of CD4+ T cells

2002 • 50 citations

Proportion of CD4⁺CD25⁺Regulatory T Cell is Increased in the Patients with Ovarian Carcinoma

2005 • 39 citations

Expression of Synovial Sarcoma X (SSX) Antigens in Epithelial Ovarian Cancer and Identification of SSX-4 Epitopes Recognized by CD4+ T Cells

2006 • 34 citations

Basiliximab reduces acute liver allograft rejection in pediatric patients

2002 • 22 citations

Regulatory T cells: prospective for clinical application in hematopoietic stem cell transplantation

2005 • 22 citations

Pre-existing T-cell immunity against mucin-1 in breast cancer patients and healthy volunteers

2005 • 20 citations