IL-2 Immunotoxin Therapy Modulates Tumor-Associated Regulatory T Cells and Leads to Lasting Immune-Mediated Rejection of Breast Cancers in neu-Transgenic Mice

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

Prevalence of Regulatory T Cells Is Increased in Peripheral Blood and Tumor Microenvironment of Patients with Pancreas or Breast Adenocarcinoma

2002 • 1,454 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

Natural versus adaptive regulatory T cells

2003 • 1,363 citations

Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood

2001 • 1,293 citations

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease.

1992 • 1,190 citations

Ex Vivo Isolation and Characterization of Cd4+Cd25+ T Cells with Regulatory Properties from Human Blood

2001 • 1,168 citations

Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells

2005 • 998 citations

Inhibition of CD4+25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide

2005 • 878 citations

Homeostatic Expansion of T Cells during Immune Insufficiency Generates Autoimmunity

2004 • 682 citations

Existent T-cell and antibody immunity to HER-2/neu protein in patients with breast cancer.

1994 • 467 citations

Sinks, suppressors and antigen presenters: how lymphodepletion enhances T cell-mediated tumor immunotherapy

2004 • 439 citations

Dendritic Cell Infiltration and Prognosis of Early Stage Breast Cancer

2004 • 437 citations

Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors

2005 • 423 citations

Recruitment of latent pools of high-avidity CD8+ T cells to the antitumor immune response

2005 • 403 citations

Human CD4+CD25+ regulatory T cells

2004 • 389 citations

Inability of a Fusion Protein of IL-2 and Diphtheria Toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to Eliminate Regulatory T Lymphocytes in Patients With Melanoma

2005 • 293 citations

Patterns of Human Tumor-Infiltrating Lymphocytes in 120 Human Cancers

1990 • 240 citations

HER-2/neu is a tumor rejection target in tolerized HER-2/neu transgenic mice.

2000 • 219 citations

Immunotoxins in cancer therapy

1999 • 214 citations

Prognostic value of tumor‐infiltrating dendritic cells expressing CD83 in human breast carcinomas

2003 • 213 citations

Natural T cell immunity against cancer.

2003 • 197 citations

Preterminal host dendritic cells in irradiated mice prime CD8+ T cell–mediated acute graft-versus-host disease

2002 • 197 citations

CD4+ CD25+ CD62+ T-Regulatory Cell Subset Has Optimal Suppressive and Proliferative Potential

2003 • 194 citations

Preterminal host dendritic cells in irradiated mice prime CD8+ T cell–mediated acute graft-versus-host disease

2002 • 172 citations

CD4⁺CD25⁺T cells responding to serologically defined autoantigens suppress antitumor immune responses

2003 • 168 citations

Pre-existent immunity to the HER-2/neu oncogenic protein in patients with HER-2/neu overexpressing breast and ovarian cancer

2000 • 161 citations

The collaboration of both humoral and cellular HER-2/neu-targeted immune responses is required for the complete eradication of HER-2/neu-expressing tumors.

2001 • 157 citations

Antigen-driven clonal proliferation, somatic hypermutation, and selection of B lymphocytes infiltrating human ductal breast carcinomas.

2003 • 155 citations

T lymphocytes that infiltrate tumors and atherosclerotic plaques produce heparin-binding epidermal growth factor-like growth factor and basic fibroblast growth factor: a potential pathologic role.

1995 • 146 citations

Specifically activated memory T cell subsets from cancer patients recognize and reject xenotransplanted autologous tumors

2004 • 117 citations

Specifically activated memory T cell subsets from cancer patients recognize and reject xenotransplanted autologous tumors

2004 • 109 citations

IFN-γ Controls the Generation/Activation of CD4+CD25+ Regulatory T Cells in Antitumor Immune Response

2005 • 102 citations

Identification and Characterization of the Immunodominant Rat HER-2/neu MHC Class I Epitope Presented by Spontaneous Mammary Tumors from HER-2/neu-Transgenic Mice

2003 • 100 citations

The CD8⁺ T cell repertoire against Her‐2/neu antigens in neu transgenic mice is of low avidity with antitumor activity

2004 • 73 citations

neu Antigen-Negative Variants Can Be Generated after neu-Specific Antibody Therapy in neu Transgenic Mice

2004 • 70 citations

Infiltrating dendritic/Langerhans cells in primary breast cancer

2000 • 62 citations

CD1a-positive infiltrating-dendritic cell density and 5-year survival from human breast cancer

2003 • 60 citations

Evaluation of pre-existent immunity in patients with primary breast cancer: molecular and cellular assays to quantify antigen-specific T lymphocytes in peripheral blood mononuclear cells.

2003 • 56 citations

Targeting diphtheria toxin to growth factor receptors

1995 • 46 citations

The role of lymphocytes and macrophages in human breast tumorigenesis: an immunohistochemical and morphometric study.

2002 • 41 citations

IL-12 enhances the generation of tumour antigen-specific Th1 CD4 T cells during ex vivo expansion

2004 • 36 citations

Soluble Cytokines Can Act as Effective Adjuvants in Plasmid DNA Vaccines Targeting Self Tumor Antigens

2003 • 25 citations

Immunoglobulin repertoire of B lymphocytes infiltrating breast medullary carcinoma

2004 • 23 citations

Prognostic significance of T-cell infiltrates, expression of β2-microglobulin and HLA-DR antigens in breast carcinoma

1994 • 21 citations

Immunotherapeutic approaches for the treatment of breast cancer.

1999 • 20 citations

Spontaneous mammary carcinomas fail to induce an immune response in syngeneic FVBN202 neu transgenic mice

2000 • 18 citations

Study of the relationship between immunohistologically demonstrated lymphocytes infiltrating human breast carcinomas and patients' survival

1991 • 16 citations

Immunotherapy for breast cancer.

2002 • 10 citations