GITR: a multifaceted regulator of immunity belonging to the tumor necrosis factor receptor superfamily

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

1998 • 1,579 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance

1999 • 1,223 citations

CD27 is required for generation and long-term maintenance of T cell immunity

2000 • 726 citations

CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor β1 Production and Responsiveness

2002 • 614 citations

Human CD25+CD4+ T Suppressor Cell Clones Produce Transforming Growth Factor β, but not Interleukin 10, and Are Distinct from Type 1 T Regulatory Cells

2002 • 440 citations

Induction offoxP3+ Regulatory T Cells in the Periphery of T Cell Receptor Transgenic Mice Tolerized to Transplants

2004 • 416 citations

A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis

1997 • 410 citations

TNF ligands and receptors – a matter of life and death

2002 • 376 citations

Frontline: GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations

2004 • 358 citations

Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells

2003 • 353 citations

Phenotypic characterization of regulatory T cells in the human decidua

2004 • 338 citations

OX40-Deficient Mice Are Defective in Th Cell Proliferation but Are Competent in Generating B Cell and CTL Responses after Virus Infection

1999 • 320 citations

Functional Impairment of CD8+ T Cells by Regulatory T Cells during Persistent Retroviral Infection

2004 • 318 citations

CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein

1997 • 294 citations

Costimulation via Glucocorticoid-Induced TNF Receptor in Both Conventional and CD25+ Regulatory CD4+ T Cells

2004 • 288 citations

Costimulation of T cells by OX40, 4-1BB, and CD27

2003 • 229 citations

Immune Responses in 4-1BB (CD137)-Deficient Mice

2002 • 221 citations

Cutting Edge: The Natural Ligand for Glucocorticoid-Induced TNF Receptor-Related Protein Abrogates Regulatory T Cell Suppression

2004 • 202 citations

Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR

1999 • 191 citations

Identification of a Novel Activation-inducible Protein of the Tumor Necrosis Factor Receptor Superfamily and Its Ligand

1999 • 188 citations

Regulatory T Cells Overexpress a Subset of Th2 Gene Transcripts

2002 • 180 citations

Role of GITR in activation response of T lymphocytes

2002 • 169 citations

Cutting Edge: Ligation of the Glucocorticoid-Induced TNF Receptor Enhances Autoreactive CD4+ T Cell Activation and Experimental Autoimmune Encephalomyelitis

2004 • 164 citations

Regulation of Murine Inflammatory Bowel Disease by CD25+ and CD25− CD4+ Glucocorticoid-Induced TNF Receptor Family-Related Gene+ Regulatory T Cells

2003 • 142 citations

Emerging Applications of the Tumor Necrosis Factor Family of Ligands and Receptors in Cancer Therapy

2003 • 114 citations

Cloning and characterization of GITR ligand

2003 • 108 citations

Ig-Reactive CD4+CD25+ T Cells from Tolerized (New Zealand Black × New Zealand White)F1 Mice Suppress In Vitro Production of Antibodies to DNA

2004 • 106 citations

GITR Activation Induces an Opposite Effect on Alloreactive CD4+ and CD8+ T Cells in Graft-Versus-Host Disease

2004 • 103 citations

Glucocorticoid hormone-induced modulation of gene expression and regulation of T-cell death: role of GITR and GILZ, two dexamethasone-induced genes

1999 • 98 citations

GITR interacts with the pro-apoptotic protein Siva and induces apoptosis

2002 • 98 citations

Identification of a ligand for glucocorticoid-induced tumor necrosis factor receptor constitutively expressed in dendritic cells

2003 • 65 citations

Bypassing tumor-associated immune suppression with recombinant adenovirus constructs expressing membrane bound or secreted GITR-L

2004 • 65 citations

Expression of Glucocorticoid Induced TNF Receptor Family Related Protein (GITR) on peripheral T cells from normal human donors and patients with non-infectious uveitis

2003 • 54 citations

Recombinant glucocorticoid induced tumor necrosis factor receptor (rGITR) induces NOS in murine macrophage

2002 • 53 citations

Soluble glucocorticoid‐induced tumor necrosis factor receptor (sGITR) increased MMP‐9 activity in murine macrophage

2003 • 44 citations

Glucocorticoid-induced TNF receptor family gene (GITR) knockout mice exhibit a resistance to splanchnic artery occlusion (SAO) shock

2004 • 38 citations

Gene Structure and Chromosomal Assignment of Mouse GITR, a Member of the Tumor Necrosis Factor/Nerve Growth Factor Receptor Family

2000 • 33 citations

Regulation of autoimmune diabetes by non‐islet‐specific T cells — a role for the glucocorticoid‐induced TNF receptor

2004 • 27 citations

The soluble glucocorticoid-induced tumor necrosis factor receptor causes cell cycle arrest and apoptosis in murine macrophages

2004 • 21 citations

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