Interaction of dendritic cells with mycobacteria: Where the action starts

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

1995 • 2,531 citations

An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.

1993 • 2,410 citations

Disseminated tuberculosis in interferon gamma gene-disrupted mice.

1993 • 1,982 citations

Proliferating dendritic cell progenitors in human blood.

1994 • 1,922 citations

Efficacy of BCG Vaccine in the Prevention of Tuberculosis

1994 • 1,875 citations

Host Defense Mechanisms Triggered by Microbial Lipoproteins Through Toll-Like Receptors

1999 • 1,679 citations

Selective Recruitment of Immature and Mature Dendritic Cells by Distinct Chemokines Expressed in Different Anatomic Sites

1998 • 1,448 citations

Origin, maturation and antigen presenting function of dendritic cells

1997 • 1,375 citations

C3d of Complement as a Molecular Adjuvant: Bridging Innate and Acquired Immunity

1996 • 1,172 citations

Identification of nitric oxide synthase as a protective locus against tuberculosis

1997 • 1,161 citations

The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing

1995 • 959 citations

In Vivo Microbial Stimulation Induces Rapid CD40 Ligand–independent Production of Interleukin 12 by Dendritic Cells and their Redistribution to T Cell Areas

1997 • 937 citations

Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses

1998 • 918 citations

THE CD1 SYSTEM: Antigen-Presenting Molecules for T Cell Recognition of Lipids and Glycolipids

1999 • 711 citations

Interleukin 12 (IL-12) Is Crucial to the Development of Protective Immunity in Mice Intravenously Infected with Mycobacterium tuberculosis

1997 • 696 citations

Toll signaling pathways in the innate immune response

2000 • 637 citations

Immunogenicity and protective efficacy of a tuberculosis DNA vaccine

1996 • 629 citations

Structural Deficiencies in Granuloma Formation in TNF Gene-Targeted Mice Underlie the Heightened Susceptibility to Aerosol Mycobacterium tuberculosis Infection, Which Is Not Compensated for by Lymphotoxin

1999 • 612 citations

Vaccination against tuberculosis by DNA injection

1996 • 513 citations

Bacterial lipopolysaccharide stimulates the production of cytokines and the expression of costimulatory molecules by human peripheral blood dendritic cells: evidence for a soluble CD14-dependent pathway.

1997 • 443 citations

Activation of human dendritic cells following infection with Mycobacterium tuberculosis.

1997 • 430 citations

The mannose receptor functions as a high capacity and broad specificity antigen receptor in human dendritic cells

1997 • 397 citations

Lethal tuberculosis in interleukin-6-deficient mutant mice

1997 • 359 citations

The Mannose Receptor Delivers Lipoglycan Antigens to Endosomes for Presentation to T Cells by CD1b Molecules

1997 • 339 citations

Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion.

1996 • 330 citations

The role of interleukin-12 in acquired immunity to Mycobacterium tuberculosis infection.

1995 • 308 citations

The role of dendritic cells in the induction and regulation of immunity to microbial infection

1999 • 308 citations

Immunoregulation by interleukin-12

1996 • 298 citations

Differential Protective Efficacy of DNA Vaccines Expressing Secreted Proteins ofMycobacterium tuberculosis

1999 • 292 citations

Uptake of Leishmania major Amastigotes Results in Activation and Interleukin 12 Release from Murine Skin–derived Dendritic Cells: Implications for the Initiation of Anti-Leishmania Immunity

1998 • 284 citations

Genetic fusion of chemokines to a self tumor antigen induces protective, T-cell dependent antitumor immunity

1999 • 278 citations

Regulation of dendritic cell trafficking: a process that involves the participation of selective chemokines

1999 • 275 citations

Neutrophils Play a Protective Nonphagocytic Role in SystemicMycobacterium tuberculosisInfection of Mice

2000 • 268 citations

Chitin particle-induced cell-mediated immunity is inhibited by soluble mannan: mannose receptor-mediated phagocytosis initiates IL-12 production.

1997 • 265 citations

Bacteria-induced neo-biosynthesis, stabilization, and surface expression of functional class I molecules in mouse dendritic cells

1998 • 262 citations

Cytokine/chemokine cascades in immunity to tuberculosis

1999 • 254 citations

Enhanced responses to a DNA vaccine encoding a fusion antigen that is directed to sites of immune induction

1998 • 251 citations

Tissue Distribution of the DEC-205 Protein That Is Detected by the Monoclonal Antibody NLDC-145

1995 • 224 citations

Bone marrow-derived dendritic cells can process bacteria for MHC-I and MHC-II presentation to T cells.

1997 • 223 citations

Coordinated events during bacteria-induced DC maturation

1999 • 219 citations

Human dendritic cell responses to lipopolysaccharide and CD40 ligation are differentially regulated by interleukin‐10

1997 • 210 citations

Vaccination against Chlamydial Genital Tract Infection after Immunization with Dendritic Cells Pulsed Ex Vivo with Nonviable Chlamydiae

1998 • 194 citations

Increased Antimycobacterial Immunity in Interleukin-10-Deficient Mice

1999 • 188 citations

CD1 Expression by Dendritic Cells in Human Leprosy Lesions: Correlation with Effective Host Immunity

1999 • 187 citations

Involvement of mannose receptor in cytokine interleukin-1beta (IL-1beta), IL-6, and granulocyte-macrophage colony-stimulating factor responses, but not in chemokine macrophage inflammatory protein 1beta (MIP-1beta), MIP-2, and KC responses, caused by attachment of Candida albicans to macrophages

1997 • 172 citations

Host Responses and Antigens Involved in Protective Immunity to Mycobacterium tuberculosis

1997 • 170 citations

Down-Regulation of CD1 on Antigen-Presenting Cells by Infection withMycobacterium tuberculosis

1998 • 169 citations

CD40 Ligand/Trimer DNA Enhances Both Humoral and Cellular Immune Responses and Induces Protective Immunity to Infectious and Tumor Challenge

1998 • 159 citations

Protection against aerosolMycobacterium tuberculosis infection usingMycobacterium bovis Bacillus Calmette Guérin-infected dendritic cells

1999 • 157 citations

Analysis of the local kinetics and localization of interleukin‐1α, tumour necrosis‘qc factor‐α and transforming growth factor‐β, during the course of experimental pulmonary tuberculosis

1997 • 146 citations

Dendritic Cell (DC)-Based Anti-Infective Strategies: DCs Engineered to Secrete IL-12 Are a Potent Vaccine in a Murine Model of an Intracellular Infection

1999 • 140 citations

Upon dendritic cell (DC) activation chemokines and chemokine receptor expression are rapidly regulated for recruitment and maintenance of DC at the inflammatory site

1999 • 133 citations

Tissue Distribution of the DEC-205 Protein That Is Detected by the Monoclonal Antibody NLDC-145

1995 • 129 citations

Mycobacterium tuberculosis‐activated dendritic cells induce protective immunityin mice

2000 • 129 citations

Mannose Receptor Mediated Antigen Uptake and Presentation in Human Dendritic Cells

1997 • 127 citations

Bacillus Calmette-Guérin mycobacteria stimulate human blood dendritic cells

1997 • 125 citations

Murine dendritic cells internalizeLeishmania major promastigotes, produce IL-12 p40 and stimulate primary T cell proliferationin vitro

1999 • 115 citations

Regulation of T lymphocyte trafficking into lymph nodes during an immune response by the chemokines macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta.

1998 • 112 citations

Modulation of antigen processing and presentation by covalently linked complement C3b fragment

1995 • 96 citations

Regulation of T Lymphocyte Trafficking into Lymph Nodes During an Immune Response by the Chemokines Macrophage Inflammatory Protein (MIP)-1α and MIP-1β

1998 • 87 citations

Human Dendritic Cells Very Efficiently Present a Heterologous Antigen Expressed on the Surface of Recombinant Gram-Positive Bacteria to CD4+ T Lymphocytes

1999 • 77 citations

Co‐immunization with DNA vaccines expressing granulocyte–macrophage colony‐stimulating factor and mycobacterial secreted proteins enhances T‐cell immunity, but not protective efficacy against Mycobacterium tuberculosis

1999 • 66 citations

Mechanisms of persistence of mycobacteria

1994 • 53 citations

Get into the groove! Targeting antigens to MHC class II

1999 • 52 citations

Human dendritic cell (DC)-based anti-infective therapy: engineering DCs to secrete functional IFN-gamma and IL-12.

1998 • 52 citations

EXPRESSION OF MONOCYTE CHEMOTACTIC PROTEIN-3 IN HUMAN MONOCYTES EXPOSED TO THE MYCOBACTERIAL CELL WALL COMPONENT LIPOARABINOMANNAN

1997 • 48 citations

Human Dendritic Cell (DC)-Based Anti-Infective Therapy: Engineering DCs to Secrete Functional IFN-γ and IL-12

1998 • 46 citations

3. Immunology of leprosy

1993 • 43 citations

Mannose Receptor Mediated Uptake of Antigens Strongly Enhances HLA-Class II Restricted Antigen Presentation by Cultured Dendritic Cells

1997 • 41 citations

The role of antigen-bound C3b in antigen processing

1996 • 15 citations

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