Co‐immunization with DNA vaccines expressing granulocyte–macrophage colony‐stimulating factor and mycobacterial secreted proteins enhances T‐cell immunity, but not protective efficacy against Mycobacterium tuberculosis

Efficacy of BCG Vaccine in the Prevention of Tuberculosis

1994 • 1,875 citations

GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells

1992 • 1,608 citations

Tuberculosis: Commentary on a Reemergent Killer

1992 • 1,400 citations

Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection.

1992 • 771 citations

Immunogenicity and protective efficacy of a tuberculosis DNA vaccine

1996 • 629 citations

Granulocyte/macrophage colony-stimulating factor and interleukin 1 mediate the maturation of murine epidermal Langerhans cells into potent immunostimulatory dendritic cells.

1988 • 565 citations

Vaccination against tuberculosis by DNA injection

1996 • 513 citations

Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines

1995 • 486 citations

Protective immunity against tuberculosis induced by vaccination with major extracellular proteins of Mycobacterium tuberculosis.

1995 • 438 citations

Effective vaccination of mice against Mycobacterium tuberculosis infection with a soluble mixture of secreted mycobacterial proteins

1994 • 431 citations

T Cell Response to Mycobacterium tuberculosis

1993 • 428 citations

Gene vaccination: plasmid DNA is more than just a blueprint

1998 • 359 citations

The kinetics of emergence and loss of mediator T lymphocytes acquired in response to infection with Mycobacterium tuberculosis.

1987 • 318 citations

Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines.

1997 • 307 citations

Differential Protective Efficacy of DNA Vaccines Expressing Secreted Proteins ofMycobacterium tuberculosis

1999 • 292 citations

Development of Th1 and Th2 Populations and the Nature of Immune Responses to Hepatitis B Virus DNA Vaccines Can Be Modulated by Codelivery of Various Cytokine Genes

1998 • 267 citations

Enhancement of cellular and humoral immune responses to hepatitis C virus core protein using DNA-based vaccines augmented with cytokine-expressing plasmids.

1997 • 257 citations

Modulation of amplitude and direction ofin vivo immune responses by co-administration of cytokine gene expression cassettes with DNA immunogens

1998 • 241 citations

Granulocyte-macrophage colony-stimulating factor activates macrophages derived from bone marrow cultures to synthesis of MHC class II molecules and to augmented antigen presentation function.

1988 • 227 citations

Evidence that granulocyte macrophage-colony-stimulating factor regulates the distribution and differentiated state of dendritic cells/Langerhans cells in human lung and lung cancers.

1993 • 198 citations

Delivery of Multiple CD8 Cytotoxic T Cell Epitopes by DNA Vaccination

1998 • 169 citations

The course of Mycobacterium tuberculosis infection in the lungs of mice lacking expression of either perforin- or granzyme-mediated cytolytic mechanisms

1997 • 166 citations

DNA multi-CTL epitope vaccines for HIV and Plasmodium falciparum: immunogenicity in mice

1998 • 140 citations

Perforin, a cytotoxic molecule which mediates cell necrosis, is not required for the early control of mycobacterial infection in mice

1997 • 138 citations

Functions and specificity of T cells following nucleic acid vaccination of mice against Mycobacterium tuberculosis infection.

1997 • 124 citations

A nine-amino acid peptide from IL-1beta augments antitumor immune responses induced by protein and DNA vaccines.

1996 • 118 citations

Inhibitory effects of chronic ethanol consumption on cellular immune responses to hepatitis C virus core protein are reversed by genetic immunizations augmented with cytokine-expressing plasmids.

1997 • 103 citations

Protective immunity against heterologous challenge with encephalomyocarditis virus by VP1 DNA vaccination: effect of coinjection with a granulocyte-macrophage colony stimulating factor gene

1997 • 85 citations

Costimulation provided by DNA immunization enhances antitumor immunity.

1997 • 79 citations

DNA vaccination with cytokine fusion constructs biases the immune response to ovalbumin

1997 • 76 citations

Induction of Antigen-Specific Tumor Immunity by Genetic and Cellular Vaccines against MAGE: Enhanced Tumor Protection by Coexpression of Granulocyte-Macrophage Colony-Stimulating Factor and B7-1

1996 • 64 citations

Granulocyte‐macrophage colony‐stimulating factor‐cultured bone marrow‐derived macrophages reveal accessory cell function and synthesis of MHC class II determinants in the absence of external stimuli

1988 • 61 citations

T-cell determinants and antibody binding sites on the major mycobacterial secretory protein MPB59 of Mycobacterium bovis

1994 • 60 citations

Selective up-regulation of macrophage function in granulocyte-macrophage colony-stimulating factor transgenic mice.

1991 • 49 citations

Amplification of T‐Cell and Antibody Responses in DNA‐Based Immunization with HIV‐1 Nef by Co‐Injection with a GM‐CSF Expression Vector

1997 • 39 citations

Pillars Article: The Kinetics of Emergence and Loss of Mediator T Lymphocytes Acquired in Response to Infection with Mycobacterium Tuberculosis. J. Immunol. 1987. 138: 293-298.

2017 • 36 citations