Human Dendritic Cell (DC)-Based Anti-Infective Therapy: Engineering DCs to Secrete Functional IFN-γ and IL-12

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

The expanding universe of T-cell subsets: Th1, Th2 and more

1996 • 3,710 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

Disseminated tuberculosis in interferon gamma gene-disrupted mice.

1993 • 1,982 citations

Vaccination of patients with B–cell lymphoma using autologous antigen–pulsed dendritic cells

1996 • 1,854 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

A Mutation in the Interferon-γ –Receptor Gene and Susceptibility to Mycobacterial Infection

1996 • 1,174 citations

Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines.

1996 • 849 citations

The Th1–Th2 hypothesis of HIV infection: new insights

1994 • 708 citations

Interleukin 12 (IL-12) Is Crucial to the Development of Protective Immunity in Mice Intravenously Infected with Mycobacterium tuberculosis

1997 • 696 citations

Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo.

1996 • 561 citations

Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo.

1993 • 487 citations

Bacterial lipopolysaccharide stimulates the production of cytokines and the expression of costimulatory molecules by human peripheral blood dendritic cells: evidence for a soluble CD14-dependent pathway.

1997 • 443 citations

Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones.

1994 • 438 citations

Impaired interleukin 12 production in human immunodeficiency virus-infected patients.

1994 • 435 citations

Activation of human dendritic cells following infection with Mycobacterium tuberculosis.

1997 • 430 citations

Restoration of HIV-Specific Cell-Mediated Immune Responses by Interleukin-12 in Vitro

1993 • 397 citations

Dendritic cells freshly isolated from human blood express CD4 and mature into typical immunostimulatory dendritic cells after culture in monocyte-conditioned medium.

1993 • 395 citations

Bone marrow-generated dendritic cells pulsed with a class I-restricted peptide are potent inducers of cytotoxic T lymphocytes.

1995 • 372 citations

Genetic Susceptibility to Leishmania : IL-12 Responsiveness in T _H 1 Cell Development

1996 • 367 citations

Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection.

1994 • 365 citations

Cytokines acting on or secreted by macrophages during intracellular infection (IL-10, IL-12, IFN-γ)

1997 • 349 citations

Dendritic cells and macrophages are required for Th1 development of CD4⁺ T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-_γ production is IFN-_γ-dependent

1993 • 346 citations

Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice.

1996 • 319 citations

Treatment of Visceral Leishmaniasis with Pentavalent Antimony and Interferon Gamma

1990 • 313 citations

Human Dendritic Cells Require Exogenous Interleukin-12–Inducing Factors to Direct the Development of Naive T-Helper Cells Toward the Th1 Phenotype

1997 • 302 citations

Murine dendritic cells pulsed in vitro with tumor antigen induce tumor resistance in vivo

1994 • 300 citations

Treatment of Refractory Disseminated Nontuberculous Mycobacterial Infection With Interferon Gamma: A Preliminary Report

1994 • 297 citations

Isolation and characterization of human peripheral blood dendritic cells.

1993 • 240 citations

Th1-Th2 Paradigm: Insights from Leprosy

1994 • 232 citations

Migration patterns of dendritic cells in the mouse. Traffic from the blood, and T cell-dependent and -independent entry to lymphoid tissues.

1988 • 215 citations

Interleukin-12 in infectious diseases

1997 • 214 citations

IL-12 synthesis by human Langerhans cells.

1996 • 186 citations

Antigen capture and major histocompatibility class II compartments of freshly isolated and cultured human blood dendritic cells.

1995 • 185 citations

Defective monocyte costimulation for IFN-gamma production in familial disseminated Mycobacterium avium complex infection: abnormal IL-12 regulation.

1996 • 174 citations

Role of dendritic cells in the priming of CD4+ T lymphocytes to peptide antigen in vivo.

1993 • 164 citations

Bone Marrow‐Derived Dendritic Cells Serve as Potent Adjuvants for Peptide‐Based Antitumor Vaccines

1997 • 144 citations

A TH1-TH2-like switch in candidiasis: new perspectives for therapy

1995 • 133 citations

Human cord blood cells as targets for gene transfer: potential use in genetic therapies of severe combined immunodeficiency disease.

1993 • 122 citations

Cytokine interactions in human immunodeficiency virus-infected individuals: roles of interleukin (IL)-2, IL-12, and IL-15.

1995 • 113 citations

IL-12 in conjunction with dendritic cells enhances antiviral CD8+ CTL responses in vitro.

1996 • 111 citations

Human dendritic Langerhans cells generated in vitro from CD34+ progenitors can prime naive CD4+ T cells and process soluble antigen.

1995 • 107 citations

T helper cell differentiation in immune response

1995 • 104 citations

T cell genetic background determines maintenance of IL-12 signaling: effects on BALB/c and B10.D2 T helper cell type 1 phenotype development.

1997 • 103 citations

In vivo migration of dendritic cells differentiated in vitro: a chimpanzee model.

1997 • 103 citations

Dendritic cells: a major story unfolds

1995 • 97 citations

Getting to the Source: Dendritic Cells as Therapeutic Reagents for the Treatment of Patients With Cancer

1997 • 95 citations

Retrovirally Transduced Human Dendritic Cells Express a Normal Phenotype and Potent T-Cell Stimulatory Capacity

1997 • 85 citations

IL-2 is necessary for the progression of leishmaniasis in susceptible murine hosts.

1993 • 80 citations

Cytokine Networks with Infection: Mycobacterial Infections, Leishmaniasis, Human Immunodeficiency Virus Infection, and Sepsis

1997 • 78 citations

Profile of human T cell response to leishmanial antigens. Analysis by immunoblotting.

1989 • 58 citations

Patients with multidrug-resistant tuberculosis with low CD4+ T cell counts have impaired Th1 responses.

1997 • 56 citations

Afferent Lymph Dendritic Cells: A Model for Antigen Capture and Presentationin Vivo

1990 • 21 citations

The Influence of Antigen-Presenting Cell Type and Interferon- on Priming and Cytokine Secretion of Leishmania major--Specific T Cells

1997 • 20 citations

The effect of interleukin-12 in ex-vivo expansion of human haemopoietic progenitors

1995 • 15 citations

Recognition of Histoplasma capsulatum yeast-cell antigens by human lymphocytes and human T-cell clones

1992 • 11 citations

Autocrine activation of hemopoietic progenitor-derived myelo-monocytic cells by IFN-gamma gene transfer.

1996 • 10 citations