CD40 Ligand/Trimer DNA Enhances Both Humoral and Cellular Immune Responses and Induces Protective Immunity to Infectious and Tumor Challenge

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

Immunological Memory and Protective Immunity: Understanding Their Relation

1996 • 1,771 citations

CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.

1996 • 1,498 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization

1996 • 1,078 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

DNA VACCINES

1997 • 977 citations

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1996 • 959 citations

Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants

1997 • 919 citations

Two types of mouse helper T-cell clone

1987 • 813 citations

Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response.

1993 • 738 citations

The Adjuvant Effect of Interleukin-12 in a Vaccine Against Leishmania major

1994 • 687 citations

Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal.

1993 • 622 citations

Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization

1997 • 526 citations

Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization.

1996 • 524 citations

Gene vaccination with naked plasmid DNA: mechanism of CTL priming.

1996 • 494 citations

Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity.

1992 • 480 citations

Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand

1995 • 476 citations

The Role of CD40 Ligand in Costimulation and T‐Cell Activation

1996 • 441 citations

Requirement for CD40 Ligand in Costimulation Induction, T Cell Activation, and Experimental Allergic Encephalomyelitis

1996 • 425 citations

CD40 Ligand-Dependent T Cell Activation: Requirement of B7-CD28 Signaling Through CD40

1996 • 421 citations

Vaccination with DNA Encoding the Immunodominant LACK Parasite Antigen Confers Protective Immunity to Mice Infected with Leishmania major

1997 • 359 citations

Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow-derived cells.

1996 • 353 citations

Expression Cloning of a Protective Leishmania Antigen

1995 • 351 citations

In vivo engineering of a cellular immune response by co-administration of IL-12 expression vector with a DNA immunogen

1997 • 347 citations

Interleukin‐12 profoundly up‐regulates the synthesis of antigen‐specific complement‐fixing IgG2a, IgG2b and IgG3 antibody subclasses in vivo

1995 • 331 citations

Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines.

1997 • 307 citations

CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response.

1996 • 300 citations

Effects of IL-12 on helper T cell-dependent immune responses in vivo.

1994 • 294 citations

Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection.

1994 • 290 citations

In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen.

1997 • 286 citations

Intranasal immunization of a DNA vaccine with IL-12- and granulocyte-macrophage colony-stimulating factor (GM-CSF)-expressing plasmids in liposomes induces strong mucosal and cell-mediated immune responses against HIV-1 antigens.

1997 • 278 citations

Cytokine enhancement of DNA immunization leads to effective treatment of established pulmonary metastases.

1996 • 245 citations

CD40 and Its Ligand in Host Defense

1996 • 236 citations

Studies on the interdependence of gp39 and B7 expression and function during antigen‐specific immune responses

1995 • 225 citations

Immunization of non-human primates with DNA vaccines

1997 • 223 citations

CD40/CD40 ligand interactions are required for T cell‐dependent production of interleukin‐12 by mouse macrophages

1996 • 184 citations

Microbial products induce autoimmune disease by an IL-12-dependent pathway.

1997 • 170 citations

Structural characteristics of CD40 ligand that determine biological function

1994 • 166 citations

Interleukin‐12 induces interferon‐γ‐dependent switching of IgG alloantibody subclass

1996 • 160 citations

IL-12 enhances vaccine-induced immunity to schistosomes by augmenting both humoral and cell-mediated immune responses against the parasite.

1996 • 113 citations

Identification of a costimulatory molecule rapidly induced by CD40L as CD44H.

1996 • 108 citations

Antigen-driven but not lipopolysaccharide-driven IL-12 production in macrophages requires triggering of CD40.

1997 • 106 citations

Immunomodulatory effects of a plasmid expressing B7‐2 on human immunodeficiency virus‐1‐specific cell‐mediated immunity induced by a plasmid encoding the viral antigen

1997 • 104 citations

Immunostimulatory effects of a plasmid expressing CD40 ligand (CD154) on gene immunization.

1997 • 102 citations

CD40L is important for induction of, but not response to, costimulatory activity. ICAM-1 as the second costimulatory molecule rapidly up-regulated by CD40L.

1996 • 101 citations

Adsorption to aluminum hydroxide promotes the activity of IL-12 as an adjuvant for antibody as well as type 1 cytokine responses to HIV-1 gp120.

1997 • 100 citations

Comparison of numerous delivery systems for the induction of cytotoxic T lymphocytes by immunization

1996 • 93 citations

Polyclonal activation of the murine immune system by a goat antibody to mouse IgD. IX. Induction of a polyclonal IgE response.

1987 • 90 citations

CD40 ligand/CD40 stimulation regulates the production of IFN-gamma from human peripheral blood mononuclear cells in an IL-12- and/or CD28-dependent manner.

1998 • 86 citations

Interleukin (IL)-4-independent immunoglobulin class switch to immunoglobulin (Ig)E in the mouse.

1996 • 84 citations

CD40L: a multi-functional ligand

1993 • 84 citations

Costimulation provided by DNA immunization enhances antitumor immunity.

1997 • 79 citations

Interleukin 12 alters the isotype-restricted antibody response of mice to hen eggwhite lysozyme

1995 • 67 citations

CD40 Ligand/CD40 Stimulation Regulates the Production of IFN-γ from Human Peripheral Blood Mononuclear Cells in an IL-12- and/or CD28-Dependent Manner

1998 • 66 citations

Membranes from both Th1 and Th2 T cell clones stimulate B cell proliferation and prepare B cells for lymphokine-induced differentiation to secrete Ig.

1991 • 56 citations

Prospects for new vaccines against tuberculosis

1995 • 52 citations

Consistent neutrino masses from cosmology and solar physics

1990 • 25 citations