IMMUNE REGULATION BY CD40 AND ITS LIGAND GP39

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Activation of human dendritic cells through CD40 cross-linking.

1994 • 1,351 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation

1994 • 1,099 citations

Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation

1993 • 1,073 citations

Two TNF receptors

1992 • 1,048 citations

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

1994 • 1,043 citations

The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family

1995 • 990 citations

B70 antigen is a second ligand for CTLA-4 and CD28

1993 • 907 citations

Normal Development of Mice Deficient in β ₂ M, MCClass I Proteins, and CD8 ⁺ T Cells

1990 • 885 citations

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

1993 • 840 citations

CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM Syndrome

1993 • 836 citations

Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule

1992 • 820 citations

Mice deficient for the CD40 ligand

1994 • 753 citations

Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM

1993 • 739 citations

CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM

1993 • 719 citations

Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity

1993 • 688 citations

Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function.

1994 • 681 citations

Induction of human IgE synthesis in B cells by mast cells and basophils

1993 • 662 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal.

1993 • 622 citations

The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro.

1994 • 607 citations

CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40.

1993 • 593 citations

Generation of Memory B Cells and Plasma Cells in Vitro

1995 • 585 citations

B Cells Turn Off Virgin But Not Memory T Cells

1992 • 578 citations

T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo.

1992 • 558 citations

Humoral immune responses in CD40 ligand-deficient mice.

1994 • 541 citations

Structure of tumour necrosis factor

1989 • 512 citations

The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding.

1989 • 511 citations

Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion.

1993 • 502 citations

Selective Events in T Cell Development

1994 • 486 citations

Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.

1995 • 481 citations

CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression.

1995 • 481 citations

Involvement of CRAF1, a relative of TRAF, in CD40 signaling

1995 • 454 citations

Germinal centres in T-cell-dependent antibody responses

1992 • 442 citations

The Structure of Tumor Necrosis Factor-α at 2.6 Å Resolution

1989 • 441 citations

Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens.

1992 • 435 citations

gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory.

1994 • 431 citations

Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand.

1995 • 426 citations

Expression of functional CD40 by vascular endothelial cells.

1995 • 414 citations

B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40

1993 • 390 citations

The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4+ T cells.

1993 • 384 citations

Identification of a novel surface protein on activated CD4+ T cells that induces contact-dependent B cell differentiation (help).

1992 • 357 citations

In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39.

1993 • 354 citations

Effects of Cyclosporine A on T Cell Development and Clonal Deletion

1988 • 354 citations

A novel RING finger protein interacts with the cytoplasmic domain of CD40.

1994 • 345 citations

Activated human T cells express a ligand for the human B cell‐associated antigen CD40 which participates in T cell‐dependent activation of B lymphocytes

1992 • 323 citations

Identification and distribution of the costimulatory receptor CD28 in the mouse.

1992 • 316 citations

Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones.

1987 • 310 citations

TRANSPLANTATION TOLERANCE INDUCED BY CTLA4-Ig1

1994 • 303 citations

TRANSPLANTATION TOLERANCE INDUCED BY CTLA4-Ig1

1994 • 294 citations

Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen.

1994 • 293 citations

CD40 is functionally expressed on human thymic epithelial cells.

1992 • 261 citations

Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28.

1994 • 257 citations

CD40 preferentially costimulates activation of CD4+ T lymphocytes.

1994 • 255 citations

In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. I. In vivo expression of CD40 ligand, cytokines, and antibody production delineates sites of cognate T-B cell interactions.

1993 • 250 citations

CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation.

1994 • 245 citations

In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice

1994 • 245 citations

Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C gamma 2.

1994 • 238 citations

The two-signal model of lymphocyte activation twenty-one years later

1992 • 233 citations

A subset of CD4+ memory T cells contains preformed CD40 ligand that is rapidly but transiently expressed on their surface after activation through the T cell receptor complex.

1995 • 231 citations

Studies on the interdependence of gp39 and B7 expression and function during antigen‐specific immune responses

1995 • 225 citations

In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice

1994 • 205 citations

Molecular interactions mediating T-B lymphocyte collaboration in human lymphoid follicles. Roles of T cell-B-cell-activating molecule (5c8 antigen) and CD40 in contact-dependent help.

1992 • 194 citations

Antibody to the ligand of CD40, gp39, blocks the occurrence of the acute and chronic forms of graft-vs-host disease.

1994 • 187 citations

The structure of human lymphotoxin (tumor necrosis factor-beta) at 1.9-A resolution.

1992 • 187 citations

Memory B cell development but not germinal center formation is impaired by in vivo blockade of CD40-CD40 ligand interaction.

1994 • 182 citations

A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40

1995 • 177 citations

In vivo and in vitro clonal deletion of double-positive thymocytes.

1992 • 172 citations

A 3-D model for the CD40 ligand predicts that it is a compact trimer similar to the tumor necrosis factors

1993 • 168 citations

Ligation of B7 with CD28/CTLA‐4 on T cells results in CD40 ligand expression, interleukin‐4 secretion and efficient help for antibody production by B cells

1993 • 153 citations

CD40 ligand is functionally expressed on human eosinophils

1995 • 149 citations

In the absence of a CD40 signal, B cells are tolerogenic

1995 • 149 citations

An essential role for gp39, the ligand for CD40, in thymic selection.

1995 • 148 citations

Induction of B cell costimulatory function by recombinant murine CD40 ligand

1994 • 148 citations

Two signals are required for negative selection of CD4+CD8+ thymocytes.

1993 • 143 citations

Cyclosporin A inhibits CD40 ligand expression in T lymphocytes.

1994 • 142 citations

Stimulation of protein tyrosine phosphorylation, phosphoinositide turnover, and multiple previously unidentified serine/threonine-specific protein kinases by the Pan-B-cell receptor CD40/Bp50 at discrete developmental stages of human B-cell ontogeny.

1991 • 139 citations

CD40 signaling pathway: anti-CD40 monoclonal antibody induces rapid dephosphorylation and phosphorylation of tyrosine-phosphorylated proteins including protein tyrosine kinase Lyn, Fyn, and Syk and the appearance of a 28-kD tyrosine phosphorylated protein.

1994 • 134 citations

Mice transgenic for a soluble form of murine CTLA-4 show enhanced expansion of antigen-specific CD4+ T cells and defective antibody production in vivo.

1994 • 132 citations

Coblockade of the LFA1:ICAM and CD28/CTLA4:B7 pathways is a highly effective means of preventing acute lethal graft-versus-host disease induced by fully major histocompatibility complex-disparate donor grafts

1995 • 119 citations

B7 expression on thymic medullary epithelium correlates with epithelium-mediated deletion of V beta 5+ thymocytes.

1994 • 118 citations

γ/δ T lymphocytes express CD40 ligand and induce isotype switching in B lymphocytes.

1995 • 112 citations

The role of LFA-1/ICAM-1 interactions during murine T lymphocyte development.

1991 • 105 citations

IL-4-producing CD8+ T cell clones can provide B cell help.

1995 • 98 citations

The regulation of T cell-dependent antibody formation in vitro by CD40 ligand and IL-2.

1993 • 97 citations

T cell-dependent induction of NF-kappa B in B cells.

1993 • 93 citations

Hyper IgM syndrome associated with defective CD40-mediated B cell activation.

1994 • 92 citations

Identification of the intracytoplasmic region essential for signal transduction through a B cell activation molecule, CD40

1990 • 90 citations

The Role of CD40 and its Ligand in the Regulation of the Immune Response

1994 • 85 citations

The role of CD40-CD40 ligand interaction in human T cell-B cell collaboration.

1994 • 85 citations

CD40: A cytokine receptor in search of a ligand

1990 • 82 citations

Deletion of antigen-specific immature thymocytes by dendritic cells requires LFA-1/ICAM interactions.

1992 • 81 citations

Identification of Residues on CD40 and Its Ligand Which Are Critical for the Receptor-Ligand Interaction

1995 • 74 citations

Receptor-specific induction of individual AP-1 components in B lymphocytes.

1995 • 72 citations

Structure-activity studies of human tumour necrosis factors

1994 • 72 citations

Signal transduction via CD4, CD8, and CD28 in mature and immature thymocytes. Implications for thymic selection.

1991 • 72 citations

Induction and reversal of long-lived specific unresponsiveness to a T-dependent antigen following CTLA4Ig treatment.

1995 • 70 citations

Analysis of gp39/CD40 Interactions Using Molecular Models and Site-Directed Mutagenesis

1995 • 60 citations

Protein tyrosine phosphorylation is mandatory for CD40‐mediated rescue of germinal center B cells from apoptosis

1993 • 60 citations

B7 costimulates proliferation of CD4-8+ T lymphocytes but is not required for the deletion of immature CD4+8+ thymocytes.

1992 • 59 citations

Membranes from both Th1 and Th2 T cell clones stimulate B cell proliferation and prepare B cells for lymphokine-induced differentiation to secrete Ig.

1991 • 56 citations

SUPPRESSED ANTIDONOR MLC RESPONSES IN RENAL TRANSPLANT CANDIDATES CONDITIONED WITH DONOR-SPECIFIC TRANSFUSIONS THAT CARRY THE RECIPIENTʼS NONINHERITED MATERNAL HLA HAPLOTYPE

1990 • 53 citations

The Effect of Combination Cyclosporine and CTLA4-Ig Therapy on Cardiac Allograft Survival

1994 • 47 citations

T cell clones from an X-linked hyper-immunoglobulin (IgM) patient induce IgE synthesis in vitro despite expression of nonfunctional CD40 ligand.

1994 • 29 citations

Mechanisms of T cell contact-dependent B cell activation.

1994 • 26 citations

The role of T cell subsets in regulating the in vivo efficacy of CTLA4-Ig in preventing graft-versus-host disease in recipients of fully MHC or multiple minor histocompatibility-disparate donor inocula.

1994 • 22 citations

Contact-dependent B-cell activation by helper T cells

1990 • 1 citations