Interleukin-11 promotes T cell polarization and prevents acute graft-versus-host disease after allogeneic bone marrow transplantation.

An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin

1996 • 937 citations

Total Body Irradiation and Acute Graft-Versus-Host Disease: The Role of Gastrointestinal Damage and Inflammatory Cytokines

1997 • 838 citations

Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers.

1989 • 761 citations

Cytokine dysregulation and acute graft-versus-host disease

1992 • 617 citations

Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease.

1987 • 609 citations

Cytokine dysregulation and acute graft-versus-host disease

1992 • 565 citations

Pretreatment of donor mice with granulocyte colony-stimulating factor polarizes donor T lymphocytes toward type-2 cytokine production and reduces severity of experimental graft-versus-host disease

1995 • 535 citations

Primary transplantation of allogeneic peripheral blood progenitor cells mobilized by filgrastim (granulocyte colony-stimulating factor) [see comments]

1995 • 508 citations

Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR)

1995 • 400 citations

Interleukin-11: Review of Molecular, Cell Biology, and Clinical Use

1997 • 386 citations

Macrophage priming and lipopolysaccharide-triggered release of tumor necrosis factor alpha during graft-versus-host disease.

1992 • 385 citations

Allogeneic peripheral blood stem cell transplantation in patients with advanced hematologic malignancies: a retrospective comparison with marrow transplantation

1996 • 370 citations

Allogeneic Peripheral Blood Stem Cell Transplantation May Be Associated With a High Risk of Chronic Graft-Versus-Host Disease

1997 • 329 citations

The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice.

1996 • 303 citations

Recombinant human IL-11 attenuates the inflammatory response through down-regulation of proinflammatory cytokine release and nitric oxide production.

1996 • 290 citations

The Th1/Th2 paradigm and the allograft response

1996 • 262 citations

IFN-gamma modulation of epithelial barrier function. Time course, reversibility, and site of cytokine binding.

1993 • 246 citations

Kinetics of Th1 and Th2 cytokine production during the early course of acute and chronic murine graft-versus-host disease. Regulatory role of donor CD8+ T cells.

1995 • 232 citations

Distinct cytokine patterns in early and chronic ileal lesions of Crohn's disease

1997 • 228 citations

CYTOKINE CASCADES IN ACUTE GRAFT-VERSUS-HOST DISEASE1

1997 • 225 citations

Polarized type 2 alloreactive CD4+ and CD8+ donor T cells fail to induce experimental acute graft-versus-host disease.

1995 • 204 citations

IL-11 regulates macrophage effector function through the inhibition of nuclear factor-kappaB.

1997 • 198 citations

Interleukin-11 prevents apoptosis and accelerates recovery of small intestinal mucosa in mice treated with combined chemotherapy and radiation.

1996 • 186 citations

Manipulation of the Th1/Th2 balance in autoimmune disease

1996 • 186 citations

Antibodies to IFN-gamma prevent immunologically mediated intestinal damage in murine graft-versus-host reaction.

1989 • 178 citations

A histopathologic study of gastric and small intestinal graft-versus-host disease following allogeneic bone marrow transplantation

1985 • 173 citations

Hepatic Graft Versus Host Disease: A Study of the Predictive Value of Liver Biopsy in Diagnosis

1984 • 169 citations

Role of cytotoxic T lymphocytes in the prevention of lupus-like disease occurring in a murine model of graft-vs-host disease.

1987 • 169 citations

A bone marrow stromal-derived growth factor, interleukin-11, stimulates recovery of small intestinal mucosal cells after cytoablative therapy

1994 • 161 citations

Cells of Th2 cytokine phenotype prevent LPS-induced lethality during murine graft-versus-host reaction. Regulation of cytokines and CD8+ lymphoid engraftment.

1994 • 147 citations

Effects of recombinant human interleukin-11 on hematopoietic reconstitution in transplant mice: acceleration of recovery of peripheral blood neutrophils and platelets

1993 • 139 citations

Allospecific CD8+ Tc1 and Tc2 populations in graft-versus-leukemia effect and graft-versus-host disease.

1996 • 137 citations

Interleukin-12 inhibits murine graft-versus-host disease

1995 • 128 citations

IL-11, a pleiotropic cytokine: exciting new effects of IL-11 on gastrointestinal mucosal biology.

1994 • 127 citations

Protection by recombinant human interleukin-11 against experimental TNB-induced colitis in rats

1996 • 118 citations

IL-2 reduces graft-versus-host disease and preserves a graft-versus-leukemia effect by selectively inhibiting CD4+ T cell activity.

1993 • 115 citations

IL-11 enhances survival and decreases TNF production after radiation-induced thoracic injury.

1996 • 112 citations

Interleukin-12 Preserves the Graft-Versus-Leukemia Effect of Allogeneic CD8 T Cells While Inhibiting CD4-Dependent Graft-Versus-Host Disease in Mice

1997 • 110 citations

Reconstitution of B cell immunity following bone marrow transplantation.

1992 • 109 citations

Interleukin-11 inhibits macrophage interleukin-12 production.

1997 • 102 citations

Protection of the Small Intestinal Clonogenic Stem Cells from Radiation‐Induced Damage by Pretreatment with Interleukin 11 also Increases Murine Survival Time

1996 • 94 citations

Neutralizing IL-12 during induction of murine acute graft-versus-host disease polarizes the cytokine profile toward a Th2-type alloimmune response and confers long term protection from disease.

1997 • 92 citations

Genetic nomenclature for loci controlling mouse lymphocyte antigens

1987 • 76 citations

The role of cytokines in acute graft-versus-host disease.

1997 • 70 citations

Alteration in the frequency, severity and duration of chemotherapy-induced mucositis in hamsters by interleukin-11

1995 • 69 citations

TRANSPLANTATION OF POLARIZED TYPE 2 DONOR T CELLS REDUCES MORTALITY CAUSED BY EXPERIMENTAL GRAFT-VERSUS-HOST DISEASE1

1996 • 65 citations

Trophic effects of interleukin-11 in rats with experimental short bowel syndrome

1996 • 65 citations

Human endothelial cell costimulation of T cell IFN-gamma production.

1997 • 58 citations

Interleukin-11 induces intestinal epithelial cell growth arrest through effects on retinoblastoma protein phosphorylation.

1996 • 54 citations

IL-12 p40 messenger RNA expression in target organs during acute graft-versus-host disease. Possible involvement of IFN-gamma.

1996 • 51 citations

IL-2 inhibits early increases in serum gamma interferon levels associated with graft-versus-host-disease.

1994 • 51 citations

Lack of a role of interleukin 11 in the growth of multiple myeloma

1992 • 43 citations

Increased survival and multilineage hematopoietic protection from delayed and severe myelosuppressive effects of a nitrosourea with recombinant interleukin-11.

1994 • 40 citations

Graft-Versus-Host Disease

1991 • 35 citations

Endogenous Interleukin-11 (IL-11) Expression Is Increased and Prophylactic Use of Exogenous IL-11 Enhances Platelet Recovery and Improves Survival During Thrombocytopenia Associated With Experimental Group B Streptococcal Sepsis in Neonatal Rats

1996 • 32 citations

NUCLEAR MAGNETIC RESONANCE OF HEPATIC GRAFT-VERSUS-HOST DISEASE IN MICE

1990 • 18 citations

A bone marrow stromal-derived growth factor, interleukin-11, stimulates recovery of small intestinal mucosal cells after cytoablative therapy

1994 • 17 citations

Interleukin-12 Preserves the Graft-Versus-Leukemia Effect of Allogeneic CD8 T Cells While Inhibiting CD4-Dependent Graft-Versus-Host Disease in Mice

1997 • 11 citations

Cellular pathology of experimental colitis induced by trinitrobenzenesulphonic acid (TNBS): Protective effects of recombinant human interleukin-11

1997 • 10 citations

Recovery of T cell populations after acute graft-vs-host reaction.

1994 • 10 citations

Effects of recombinant human interleukin-11 on hematopoietic reconstitution in transplant mice: acceleration of recovery of peripheral blood neutrophils and platelets

1993 • 8 citations

Donor lymphoid cells of Th2 cytokine phenotype reduce lethal graft versus host disease and facilitate fully allogeneic cell transfers in sublethally irradiated mice.

1994 • 7 citations

Interaction of interleukin-11 with cytotoxic therapiesin vitro against CEM cells andin vivo against EMT-6 murine mammary carcinoma

1996 • 7 citations

Interaction of interleukin‐11 with cytotoxic therapies in vitro against CEM cells and in vivo against EMT‐6 murine mammary carcinoma

1996 • 1 citations