Radiosensitization by targeting radioresistance-related genes with protein kinase A inhibitor in radioresistant cancer cells

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

Sensing and repairing DNA double-strand breaks

2002 • 1,112 citations

The DNA-dependent protein kinase

1999 • 896 citations

Role of chemopreventive agents in cancer therapy

2004 • 530 citations

Homologous and non-homologous recombination differentially affect DNA damage repair in mice

2000 • 245 citations

DNA repair and recombination factor Rad51 is over-expressed in human pancreatic adenocarcinoma

2000 • 209 citations

Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002

2003 • 179 citations

Interactive competition between homologous recombination and non-homologous end joining.

2003 • 173 citations

Genetic Analysis of the DNA-dependent Protein Kinase Reveals an Inhibitory Role of Ku in Late S–G2 Phase DNA Double-strand Break Repair

2001 • 163 citations

Gene expression profiling after irradiation: Clues to understanding acute and persistent responses?

2004 • 163 citations

Repair of radiation damage to DNA

2004 • 146 citations

Differential gene expression profiles of radioresistant oesophageal cancer cell lines established by continuous fractionated irradiation

2004 • 140 citations

The Molecular and Cellular Basis of Radiosensitivity: Implications for Understanding How Normal Tissues and Tumors Respond to Therapeutic Radiation

1999 • 113 citations

Activation of nuclear factor kappaB in radioresistance of TP53-inactive human keratinocytes.

2002 • 102 citations

Didox (A Novel Ribonucleotide Reductase Inhibitor) Overcomes bcl-2 Mediated Radiation Resistance in Prostate Cancer Cell Line PC-3

2002 • 101 citations

Protein Kinase A as Target for Novel Integrated Strategies of Cancer Therapy

2002 • 100 citations

Overexpression of Bcl‐2 in squamous cell carcinoma of the larynx: A marker of radioresistance

2002 • 82 citations

Evidence Supporting a Signal Transduction Pathway Leading to the Radiation-Resistant Phenotype in Human Tumor Cells

1997 • 76 citations

Enhanced radiosensitization and chemosensitization in NF‐κB‐suppressed human oral cancer cells via the inhibition of γ‐irradiation‐ and 5‐FU‐induced production of IL‐6 and IL‐8

2004 • 72 citations

Association of DNA-dependent protein kinase with hypoxia inducible factor-1 and its implication in resistance to anticancer drugs in hypoxic tumor cells

2004 • 68 citations

Involvement of ROS and JNK1 in selenite-induced a poptosisin Chang liver cells

2004 • 67 citations

Increased expression of DNA-dependent protein kinase confers resistance to adriamycin

1998 • 64 citations

The radioprotective effect of the 24 kDa FGF-2 isoform in HeLa cells is related to an increased expression and activity of the DNA dependent protein kinase (DNA-PK) catalytic subunit

2002 • 59 citations

BCL-2 family proteins modulate radiosensitivity in human malignant glioma cells.

2002 • 54 citations

Protein kinase A inhibitors enhance radiation‐induced apoptosis

1995 • 54 citations

Activation of the phosphatidylinositol 3-kinase/Akt pathway prevents radiation-induced apoptosis in breast cancer cells

2005 • 49 citations

Evidence for the involvement of DNA-dependent protein kinase in the phenomena of low dose hyper-radiosensitivity and increased radioresistance

2002 • 49 citations

Potentiation of chemosensitivity in multidrug-resistant human leukemia CEM cells by inhibition of DNA-dependent protein kinase using wortmannin

2000 • 47 citations

Increased and correlated nuclear factor-kappa B and Ku autoantigen activities are associated with development of multidrug resistance

2001 • 46 citations

Increased expression of human DNA repair genes, XRCC1, XRCC3 and RAD51, in radioresistant human KB carcinoma cell line N10

1998 • 45 citations

Relationship between Antiapoptotic Molecules and Metastatic Potency and the Involvement of DNA-Dependent Protein Kinase in the Chemosensitization of Metastatic Human Cancer Cells by Epidermal Growth Factor Receptor Blockade

2004 • 41 citations

Activation of stress-responsive promoters by ionizing radiation for deployment in targeted gene therapy

2004 • 31 citations

Cell cycle alteration, apoptosis and response of leukemic cell lines to gamma radiation with high- and low-dose rate.

2004 • 31 citations

Antisense Targeting Protein Kinase A Type I as a Drug for Integrated Strategies of Cancer Therapy

2003 • 25 citations

The Molecular and Cellular Basis of Radiosensitivity: Implications for Understanding How Normal Tissues and Tumors Respond to Therapeutic Radiation

1999 • 25 citations

Bis induces growth inhibition and differentiation of HL-60 cells via up-regulation of p27

2005 • 21 citations

Alteration of gene expression during radiation-induced resistance and tumorigenesis in NIH3T3 cells revealed by cDNA microarrays: involvement of MDM2 and CDC25B

2003 • 14 citations

Identification of Radiation-Responsive GenesIn VitroUsing a Gene Trap Strategy Predicts for Modulation of Expression by RadiationIn Vivo

2002 • 13 citations

Signal Transduction Inhibitors as Radiosensitizers

2002 • 12 citations

Changes in Gene Expression Associated with Stable Drug and Radiation Resistance in Small Cell Lung Cancer Cells are Similar to those Caused by a Single X-Ray Dose

2004 • 11 citations