Potentiation of chemosensitivity in multidrug-resistant human leukemia CEM cells by inhibition of DNA-dependent protein kinase using wortmannin

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase.

1994 • 678 citations

DNA-Dependent Kinase (p350) as a Candidate Gene for the Murine SCID Defect

1995 • 610 citations

Absence of p350 Subunit of DNA-Activated Protein Kinase from a Radiosensitive Human Cell Line

1995 • 530 citations

Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.

1998 • 526 citations

Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts.

1979 • 478 citations

Expression of bcl-xL can confer a multidrug resistance phenotype

1995 • 421 citations

Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

1997 • 396 citations

Restoration of X-ray Resistance and V(D)J Recombination in Mutant Cells by Ku cDNA

1994 • 351 citations

Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks.

1993 • 311 citations

Quercetin potentiates the effect of adriamycin in a multidrug-resistant MCF-7 human breast-cancer cell line: P-glycoprotein as a possible target

1994 • 263 citations

Direct correlation between DNA topoisomerase II activity and cytotoxicity in adriamycin-sensitive and -resistant P388 leukemia cell lines.

1989 • 263 citations

Functional interaction between DNA-PK and c-Abl in response to DNA damage

1997 • 254 citations

Stimulation of the DNA-dependent Protein Kinase by Poly(ADP-Ribose) Polymerase

1998 • 237 citations

Multidrug-resistant myeloma: laboratory and clinical effects of verapamil as a chemosensitizer

1991 • 228 citations

Competitive and noncompetitive inhibition of the DNA-dependent protein kinase.

1999 • 176 citations

DNA-PK: at the cross-roads of biochemistry and genetics

1997 • 169 citations

The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes murine fibroblasts and human tumor cells to radiation and blocks induction of p53 following DNA damage.

1996 • 149 citations

Mammalian mutants defective in the response to ionizing radiation-induced DNA damage

1995 • 122 citations

Multidrug resistance of cancer cells

1996 • 89 citations

DNA-Dependent Protein Kinase Activity Correlates With Clinical and In Vitro Sensitivity of Chronic Lymphocytic Leukemia Lymphocytes to Nitrogen Mustards

1998 • 87 citations

p95^vavAssociates with the Nuclear Protein Ku-70

1996 • 79 citations

MULTIDRUG RESISTANCE IN LEUKAEMIA

1997 • 76 citations

A phosphatidylinositol 3-kinase inhibitor wortmannin induces radioresistant DNA synthesis and sensitizes cells to bleomycin and ionizing radiation

1998 • 75 citations

DNA-Dependent Protein Kinase Phosphorylation of IκBα and IκBβ Regulates NF-κB DNA Binding Properties

1998 • 72 citations

Ku autoantigen affects the susceptibility to anticancer drugs.

1999 • 65 citations

Increased expression of DNA-dependent protein kinase confers resistance to adriamycin

1998 • 64 citations

Binding of an optically pure photoaffinity analogue of verapamil, LU-49888, to P-glycoprotein from multidrug-resistant human leukemic cell lines.

1990 • 63 citations

Functions of the DNA dependent protein kinase.

1997 • 59 citations

Absence of autoantigen Ku in mature human neutrophils and human promyelocytic leukemia line (HL-60) cells and lymphocytes undergoing apoptosis.

1995 • 57 citations

Potentiation of chlorambucil cytotoxicity in B-cell chronic lymphocytic leukemia by inhibition of DNA-dependent protein kinase activity using wortmannin.

1998 • 52 citations

The DNA-dependent protein kinase catalytic subunit (p460) is cleaved during Fas-mediated apoptosis in Jurkat cells.

1997 • 49 citations

Reduced topoisomerase II and elevated α class glutathione S-transferase expression in a multidrug resistant CHO cell line highly cross-resistant to mitomycin C

1992 • 44 citations

Differences between drug-sensitive and -resistant human leukemic CEM cells in c-jun expression, AP-1 DNA-binding activity, and formation of Jun/Fos family dimers, and their association with internucleosomal DNA ladders after treatment with VM-26.

1994 • 44 citations

Cellular Resistance to Cancer Chemotherapy

1994 • 40 citations

Growth inhibition, cytokinesis failure and apoptosis of multidrug-resistant leukemia cells after treatment with P-glycoprotein inhibitory agents

1999 • 39 citations

DNA-dependent Protein Kinase Protects against Heat-induced Apoptosis

1999 • 36 citations

The Relationship Between Modulation of MDR and Glutathione in MRP-Overexpressing Human Leukemia Cells

1998 • 30 citations

Site‐specific proteolytic cleavage of Ku protein bound to DNA

1993 • 30 citations

Expressions of DNA topoisomerase I and II gene and the genes possibly related to drug resistance in human myeloma cells

1993 • 26 citations

Inhibition of MDR1 gene expression by H-87, a selective inhibitor of cAMP-dependent protein kinase

1993 • 25 citations

Resistance to Apoptosis Induced by Topoisomerase I Inhibitors in Multidrug-Resistant HL60 Leukemic Cells

1998 • 19 citations

Chemoresistance to doxorubicin and cisplatin in a murine cell line. Analysis of P-glycoprotein, topoisomerase II activity, glutathione and related enzymes.

1994 • 13 citations