Increased and correlated nuclear factor-kappa B and Ku autoantigen activities are associated with development of multidrug resistance

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

Therapeutic potential of inhibition of the NF-κB pathway in the treatment of inflammation and cancer

2001 • 1,548 citations

Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB

2001 • 1,427 citations

Apoptosis in cancer therapy: Crossing the threshold

1994 • 1,351 citations

Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB

1999 • 1,001 citations

The DNA-dependent protein kinase

1999 • 896 citations

The Transcriptional Activity of NF-κB Is Regulated by the IκB-Associated PKAc Subunit through a Cyclic AMP–Independent Mechanism

1997 • 820 citations

DNA Damaging Agents Induce Expression of Fas Ligand and Subsequent Apoptosis in T Lymphocytes via the Activation of NF-κB and AP-1

1998 • 726 citations

Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

1994 • 637 citations

NF-κB Induces Expression of the Bcl-2 Homologue A1/Bfl-1 To Preferentially Suppress Chemotherapy-Induced Apoptosis

1999 • 574 citations

Absence of p350 Subunit of DNA-Activated Protein Kinase from a Radiosensitive Human Cell Line

1995 • 530 citations

Expression of bcl-xL can confer a multidrug resistance phenotype

1995 • 421 citations

Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

1997 • 396 citations

The transcription factor NF-κB: control of oncogenesis and cancer therapy resistance

2000 • 324 citations

DNA-dependent protein kinase acts upstream of p53 in response to DNA damage

1998 • 313 citations

Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks.

1993 • 311 citations

Nuclear clusterin/XIP8, an x-ray-induced Ku70-binding protein that signals cell death

2000 • 279 citations

The pro‐ or anti‐apoptotic function of NF‐κB is determined by the nature of the apoptotic stimulus

2000 • 250 citations

NF-κB-mediated Induction of mdr1b Expression by Insulin in Rat Hepatoma Cells

1997 • 191 citations

DNA-PK: at the cross-roads of biochemistry and genetics

1997 • 169 citations

Inducible chemoresistance to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothe cin (CPT-11) in colorectal cancer cells and a xenograft model is overcome by inhibition of nuclear factor-kappaB activation.

2000 • 160 citations

Regulation of inducible gene expression by the transcription factor NF-κB

1999 • 129 citations

The DNA-Dependent Protein Kinase Participates in the Activation of NFκB Following DNA Damage

1998 • 113 citations

Stable inhibition of nuclear factor kappaB in cancer cells does not increase sensitivity to cytotoxic drugs.

1999 • 88 citations

Apoptosis and radiosensitization of Hodgkin cells by proteasome inhibition

2000 • 86 citations

MULTIDRUG RESISTANCE IN LEUKAEMIA

1997 • 76 citations

DNA-Dependent Protein Kinase Phosphorylation of IκBα and IκBβ Regulates NF-κB DNA Binding Properties

1998 • 72 citations

Increased expression of DNA-dependent protein kinase confers resistance to adriamycin

1998 • 64 citations

Differential etoposide sensitivity of cells deficient in the Ku and DNA- PKcs components of the DNA-dependent protein kinase

1998 • 62 citations

Changes in Expression of the DNA Repair Protein Complex DNA-Dependent Protein Kinase after Ischemia and Reperfusion

1999 • 60 citations

Sequential emergence ofMRP- andMDR1-gene over-expression as well asMDR1-gene translocation in homoharringtonine-selected K562 human leukemia cell lines

1996 • 60 citations

Potentiation of chlorambucil cytotoxicity in B-cell chronic lymphocytic leukemia by inhibition of DNA-dependent protein kinase activity using wortmannin.

1998 • 52 citations

The p53 Response to DNA Damage In Vivo Is Independent of DNA-Dependent Protein Kinase

2000 • 52 citations

A Model for Ku Heterodimer Assembly and Interaction with DNA

1998 • 51 citations

Expression of MDR1 and glutatione S transferase-π genes and chemosensitivities in human gastrointestinal cancer

1992 • 51 citations

Potentiation of chemosensitivity in multidrug-resistant human leukemia CEM cells by inhibition of DNA-dependent protein kinase using wortmannin

2000 • 47 citations

DNA-dependent protein kinase activity correlates with Ku70 expression and radiation sensitivity in esophageal cancer cell lines.

2000 • 45 citations

The transcriptional repressor ICER and cAMP-induced programmed cell death

1997 • 41 citations

The effect of cyclic-AMP on the regulation of c-myc expression in T lymphoma cells.

1995 • 39 citations

Antiapoptotic role of NF‐κB in the auto‐oxidized dopamine‐induced apoptosis of PC12 cells

2001 • 37 citations

DNA-dependent Protein Kinase Protects against Heat-induced Apoptosis

1999 • 36 citations

The immunohistochemical expression of DNA-PKcs and Ku (p70/p80) in head and neck cancers: relationships with radiosensitivity

1999 • 34 citations

Downregulation of JNK/SAPK Activity Is Associated with the Cross-Resistance to P-Glycoprotein-Unrelated Drugs in Multidrug-Resistant FM3A/M Cells Overexpressing P-Glycoprotein

2000 • 34 citations

Inhibition of MDR1 gene expression by H-87, a selective inhibitor of cAMP-dependent protein kinase

1993 • 25 citations

Resistance to Apoptosis Induced by Topoisomerase I Inhibitors in Multidrug-Resistant HL60 Leukemic Cells

1998 • 19 citations

Cross-resistance patterns related to glutathione metabolism in primary human renal cell carcinoma

1991 • 19 citations

Prevention of etoposide-induced apoptosis by proteasome inhibitors in a human leukemic cell line but not in fresh acute leukemia blasts

2000 • 17 citations

DNA-Dependent Protein Kinase Activity Correlates With Clinical and In Vitro Sensitivity of Chronic Lymphocytic Leukemia Lymphocytes to Nitrogen Mustards

1998 • 14 citations

MDR hamster cells exhibiting multiple altered gene expression: effects of dexniguldipine-HCl (B859-35), cyclosporin A and buthionine sulfoximine.

1992 • 12 citations

Cross-resistance to cis-diamminedichloroplatinum(II) of a multidrug-resistant lymphoma cell line associated with decreased drug accumulation and enhanced DNA repair

1996 • 11 citations

Increased Intracellular cAMP Renders HL-60 Cells Resistant to Cytotoxicity of Taxol

1999 • 8 citations

[p53 activation by PI-3K family kinases after DNA double-strand breaks].

2000 • 7 citations

AUTHOR INDEX FOR VOLUME 261

1997 • 3 citations

Meeting the Challenge of Obesity

1999 • 1 citations

On the role of mitochondrial complex I in apoptosis induced by anti-cancer drugs

2000 • 1 citations