Relationship between Antiapoptotic Molecules and Metastatic Potency and the Involvement of DNA-Dependent Protein Kinase in the Chemosensitization of Metastatic Human Cancer Cells by Epidermal Growth Factor Receptor Blockade

Epidermal growth factor-related peptides and their receptors in human malignancies

1995 • 2,689 citations

Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor.

2000 • 934 citations

Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase.

2000 • 766 citations

Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck.

1999 • 707 citations

The Clinical Significance of Epidermal Growth Factor Receptor (EGF-R) in Human Breast Cancer: A Review on 5232 Patients*

1992 • 585 citations

Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma.

2000 • 505 citations

Why the Epidermal Growth Factor Receptor? The Rationale for Cancer Therapy

2002 • 482 citations

Apoptosis pathways in cancer and cancer therapy

2004 • 457 citations

Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer Is correlated with survival.

2001 • 455 citations

Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225.

1999 • 335 citations

Receptor tyrosine kinases as targets for anticancer drugs

2002 • 251 citations

Recent Progress in the Development of Anticancer Agents

2002 • 186 citations

Up‐regulation of DNA‐dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma

2003 • 123 citations

Myeloid leukemias have increased activity of the nonhomologous end-joining pathway and concomitant DNA misrepair that is dependent on the Ku70/86 heterodimer.

2002 • 122 citations

Apoptosis and the response to anticancer therapy

2001 • 90 citations

Genes that regulate metastasis and angiogenesis.

2000 • 86 citations

Small-Molecule Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors

2003 • 83 citations

Biological modifiers as potential radiosensitizers: targeting the epidermal growth factor receptor family.

2000 • 78 citations

Molecular mechanisms underlying the interaction between ZD1839 (‘Iressa’) and cisplatin/5-fluorouracil

2003 • 77 citations

Optimization for the blockade of epidermal growth factor receptor signaling for therapy of human pancreatic carcinoma.

2001 • 73 citations

Examining the Relationship between Cancer Invasion / Metastasis and Drug Resistance

2002 • 71 citations

Selection with melphalan or paclitaxel (Taxol) yields variants with different patterns of multidrug resistance, integrin expression and in vitro invasiveness

2001 • 69 citations

Ku autoantigen affects the susceptibility to anticancer drugs.

1999 • 65 citations

Increased expression of DNA-dependent protein kinase confers resistance to adriamycin

1998 • 64 citations

DNA-dependent protein kinase content and activity in lung carcinoma cell lines: correlation with intrinsic radiosensitivity

1999 • 59 citations

Ku86 Variant Expression and Function in Multiple Myeloma Cells Is Associated with Increased Sensitivity to DNA Damage

2000 • 53 citations

Reduced Survival of Rectal Cancer Patients With Increased Tumor Epidermal Growth Factor Receptor Levels

2003 • 51 citations

Regulation of DNA-dependent protein kinase activity in leukemic cells

1997 • 48 citations

Potentiation of chemosensitivity in multidrug-resistant human leukemia CEM cells by inhibition of DNA-dependent protein kinase using wortmannin

2000 • 47 citations

Molecular markers in clinical radiation oncology

2003 • 46 citations

Increased and correlated nuclear factor-kappa B and Ku autoantigen activities are associated with development of multidrug resistance

2001 • 46 citations

Epidermal growth factor receptor blockade potentiates apoptosis mediated by Paclitaxel and leads to prolonged survival in a murine model of oral cancer.

2003 • 41 citations

Clinical studies with non-iressa EGFR tyrosine kinase inhibitors

2003 • 32 citations

DNA Repair: Relationship to Drug and Radiation Resistance, Metastasis and Growth Factors

1985 • 28 citations

Epidermal growth factor receptor tyrosine kinase inhibitors in late stage clinical trials

2003 • 28 citations

Involvement of DNA-dependent protein kinase in regulation of the mitochondrial heat shock proteins

2003 • 21 citations

What is the relationship between P-glycoprotein and adhesion molecule expression in melanoma cells?

2002 • 13 citations

Relationship between intrinsic radiation sensitivity and metastatic potential

1996 • 11 citations

Isolation and characterisation of radioresistant human KB carcinoma cells in vitro

1998 • 8 citations

Expression of bcl-2 and Bax in EGFR-antisense transfected and untransfected glioblastoma cells.

2000 • 7 citations

Genomic instability of murine hepatocellular carcinomas with low and high metastatic capacities

2004 • 6 citations

Homologous recombination in variants of the B16 murine melanoma with reference to their metastatic potential.

1996 • 6 citations

Homologous recombination in variants of the B16 murine melanoma with reference to their metastatic potential

1996 • 4 citations