Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

1988 • 1,562 citations

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

1989 • 1,015 citations

Genes and Antibodies

1959 • 675 citations

Junctional sequences of T cell receptor γδ genes: Implications for γδ T cell lineages and for a novel intermediate of V-(D)-J joining

1989 • 572 citations

Somatic hypermutagenesis in immunoglobulin genes

1992 • 458 citations

Most peripheral B cells in mice are ligand selected.

1991 • 424 citations

Molecular and cellular origins of B lymphocyte diversity

1991 • 346 citations

Origin of Antibody Variation

1966 • 314 citations

Evidence for the clonal abortion theory of B-lymphocyte tolerance.

1975 • 293 citations

In vitro tolerance induction of neonatal murine B cells.

1976 • 281 citations

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots.

1993 • 271 citations

Somatic generation of diversity in a mammalian primary lymphoid organ: The sheep ileal Peyer's patches

1991 • 269 citations

The evolution and involution of Peyer's patches in fetal and postnatal sheep

1983 • 266 citations

Somatic diversification of immunoglobulin heavy chain VDJ genes: Evidence for somatic gene conversion in rabbits

1990 • 255 citations

Discriminating intrinsic and actigen-selected mutational hotspots in immunoglobulin V genes

1993 • 222 citations

Modification of B Lymphocyte Differentiation by Anti-Immunoglobulins

1974 • 106 citations

Surface IgM mediated regulation of RAG gene expression in E mu-N-myc B cell lines.

1992 • 90 citations

V-region directed selection in differentiating B lymphocytes.

1993 • 88 citations

Evidence of extensive lymphocyte death in sheep Peyer's patches. I. A comparison of lymphocyte production and export.

1986 • 84 citations

Surface expression of differentiation antigens on lymphocytes in the ileal and jejunal Peyer's patches of lambs.

1989 • 71 citations

The follicle‐associated epithelium of the ileal Peyer's patch in ruminants is distinguished by its shedding of 50 nm particles

1987 • 58 citations

Differential peripheral expansion and in vivo antigen reactivity of α/β and γ/δ T cells emigrating from the early fetal lamb thymus

1990 • 50 citations

Role of environmental antigens in B cell proliferation in the bursa of Fabricius at neonatal stage

1993 • 42 citations

B cell repertoire in adult antigen‐free and conventional neonatal balb/c mice

1989 • 38 citations

Differential expression of VH gene families in peripheral B cell repertoires of newborn or adult immunoglobulin H chain congenic mice.

1992 • 35 citations

Kinetics of B cell subpopulations in peripheral lymphoid tissues: evidence for the presence of phenotypically distinct short-lived and long-lived B cell subsets

1993 • 33 citations

The influence of gut function on lymphoid cell populations in the intestinal mucosa of lambs.

1983 • 26 citations

The development and physiology of the gut-associated lymphoid system in lambs

2011 • 13 citations