Ghrelin: An orexigenic and somatotrophic signal from the stomach

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

1999 • 8,261 citations

Central nervous system control of food intake

2000 • 6,305 citations

Leptin and the regulation of body weight in mammals

1998 • 5,366 citations

Ghrelin induces adiposity in rodents

2000 • 3,915 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

A role for ghrelin in the central regulation of feeding

2001 • 3,415 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

Role of leptin in the neuroendocrine response to fasting

1996 • 3,106 citations

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

2001 • 2,288 citations

A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release

1996 • 2,048 citations

Circulating Ghrelin Levels Are Decreased in Human Obesity

2001 • 1,999 citations

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

1997 • 1,891 citations

Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein

1997 • 1,835 citations

Ghrelin, a Novel Growth Hormone-Releasing Acylated Peptide, Is Synthesized in a Distinct Endocrine Cell Type in the Gastrointestinal Tracts of Rats and Humans¹

2000 • 1,794 citations

The role of neuropeptide Y in the antiobesity action of the obese gene product

1995 • 1,521 citations

The Novel Hypothalamic Peptide Ghrelin Stimulates Food Intake and Growth Hormone Secretion

2000 • 1,521 citations

Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight*

1999 • 1,467 citations

Leptin

2000 • 1,368 citations

The Leptin Receptor

1997 • 1,300 citations

Hypothalamic CART is a new anorectic peptide regulated by leptin

1998 • 1,283 citations

Growth Hormone-Releasing Factor from a Human Pancreatic Tumor That Caused Acromegaly

1982 • 1,263 citations

The stomach is a source of leptin

1998 • 1,215 citations

Signals That Regulate Food Intake and Energy Homeostasis

1998 • 1,190 citations

Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin

2001 • 1,181 citations

From Lesions to Leptin

1999 • 1,165 citations

Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis.

1979 • 1,145 citations

Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues

1997 • 1,137 citations

Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons

1998 • 1,136 citations

Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y

1996 • 1,020 citations

Ghrelin and Des-acyl Ghrelin: Two Major Forms of Rat Ghrelin Peptide in Gastrointestinal Tissue

2000 • 924 citations

Ghrelin Stimulates Gastric Acid Secretion and Motility in Rats

2000 • 875 citations

Ghrelin, an Endogenous Growth Hormone Secretagogue, Is a Novel Orexigenic Peptide That Antagonizes Leptin Action Through the Activation of Hypothalamic Neuropeptide Y/Y1 Receptor Pathway

2001 • 862 citations

Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus

1997 • 837 citations

Ghrelin Strongly Stimulates Growth Hormone Release in Humans

2000 • 835 citations

The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice

1998 • 802 citations

Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord

1998 • 797 citations

Insulin in the Brain: A Hormonal Regulator of Energy Balance*

1992 • 784 citations

Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus

1997 • 731 citations

Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food.

1991 • 678 citations

Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice.

1997 • 670 citations

On thein Vitroandin VivoActivity of a New Synthetic Hexapeptide that Acts on the Pituitary to Specifically Release Growth Hormone*

1984 • 652 citations

Upregulation of Ghrelin Expression in the Stomach upon Fasting, Insulin-Induced Hypoglycemia, and Leptin Administration

2001 • 629 citations

Integration of NPY, AGRP, and Melanocortin Signals in the Hypothalamic Paraventricular Nucleus

1999 • 603 citations

Neuropeptide Regulation of Appetite and Weight*

1987 • 598 citations

Co-Localization of Growth Hormone Secretagogue Receptor and NPY mRNA in the Arcuate Nucleus of the Rat

1999 • 592 citations

Structure−Function Studies on the New Growth Hormone-Releasing Peptide, Ghrelin: Minimal Sequence of Ghrelin Necessary for Activation of Growth Hormone Secretagogue Receptor 1a

2000 • 546 citations

What’s in a Name? In Search of Leptin’s Physiologic Role¹

1998 • 527 citations

Peptidomimetic Regulation of Growth Hormone Secretion

1997 • 520 citations

Unraveling the central nervous system pathways underlying responses to leptin

1998 • 520 citations

Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor

2001 • 517 citations

Obesity and the Hypothalamus: Novel Peptides for New Pathways

1998 • 448 citations

The Regulation of Growth Hormone Secretion

2015 • 440 citations

Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice

1997 • 435 citations

Growth Hormone-Releasing Hormone*

1986 • 427 citations

Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice

1997 • 425 citations

Receptor for Motilin Identified in the Human Gastrointestinal System

1999 • 396 citations

Ghrelin, A Novel Placental-Derived Hormone¹

2001 • 377 citations

Purification and Characterization of Rat des-Gln14-Ghrelin, a Second Endogenous Ligand for the Growth Hormone Secretagogue Receptor

2000 • 376 citations

Central Effect of Ghrelin, an Endogenous Growth Hormone Secretagogue, on Hypothalamic Peptide Gene Expression

2000 • 362 citations

Systemic Administration of Ghrelin Induces Fos and Egr‐1 Proteins in the Hypothalamic Arcuate Nucleus of Fasted and Fed Rats

2000 • 352 citations

Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus.

1999 • 347 citations

Cancer anorexia-cachexia syndrome: are neuropeptides the key?

1999 • 345 citations

Molecular Analysis of Rat Pituitary and Hypothalamic Growth Hormone Secretagogue Receptors

1997 • 341 citations

Feeding and body-weight regulation by hypothalamic neuropeptides—mediation of the actions of leptin

1999 • 330 citations

Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue.

1995 • 323 citations

The New Biology of Gastrointestinal Hormones

1998 • 323 citations

Long-term orexigenic effects of AgRP-(83—132) involve mechanisms other than melanocortin receptor blockade

2000 • 318 citations

Central Effects of a Novel Acylated Peptide, Ghrelin, on Growth Hormone Release in Rats

2000 • 316 citations

The Expression of the Growth Hormone Secretagogue Receptor Ligand Ghrelin in Normal and Abnormal Human Pituitary and Other Neuroendocrine Tumors1

2001 • 315 citations

On the Actions of the Growth Hormone-Releasing Hexapeptide, GHRP*

1991 • 308 citations

The role of gastrointestinal vagal afferents in the control of food intake: current prospects

2000 • 283 citations

Ghrelin-induced growth hormone secretion in humans

2000 • 278 citations

Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor

1999 • 276 citations

Central nervous system mechanisms contributing to the cachexia–anorexia syndrome

2000 • 264 citations

Erythromycin and other macrolides as prokinetic agents

1993 • 262 citations

Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects.

1996 • 256 citations

Novel insights into the neuroendocrinology of critical illness

2000 • 256 citations

Defense of differfing body weight set points in diet-induced obese and resistant rats

1998 • 252 citations

Cholecystokinin and satiety: current perspectives

2000 • 244 citations

Motilin and Clinical Application

1997 • 243 citations

Toward a new neurobiology of energy balance, appetite, and obesity: The anatomists weigh in

1998 • 239 citations

Ghrelin elicits a marked stimulatory effect on GH secretion in freely-moving rats

2000 • 235 citations

Identification and characterization of a novel gastric peptide hormone: The motilin-related peptide

2000 • 233 citations

Design, Synthesis, and Biological Activity of Peptides which Release Growth Hormone in Vitro*

1981 • 210 citations

Neuroendocrinology of Prolonged Critical Illness: Effects of Exogenous Thyrotropin-Releasing Hormone and Its Combination with Growth Hormone Secretagogues¹

1998 • 207 citations

The arcuate nucleus as a primary site of satiety effect of leptin in rats

1997 • 201 citations

Neuropeptide Y feeding receptors: are multiple subtypes involved?

1999 • 200 citations

Identification of a new G-protein-linked receptor for growth hormone secretagogues.

1996 • 199 citations

Structure-Activity Relationships of a Synthetic Pentapeptide that Specifically Releases Growth Hormonein Vitro*

1980 • 197 citations

Hypothalamic response to starvation: implications for the study of wasting disorders

1995 • 183 citations

Systemic administration of growth hormone-releasing peptide activates hypothalamic arcuate neurons

1993 • 182 citations

In vivo and in vitro Effects of Ghrelin/Motilin-Related Peptide on Growth Hormone Secretion in the Rat

2001 • 174 citations

The MONA LISA hypothesis in the time of leptin.

1998 • 172 citations

Two types of leptin-responsive gastric vagal afferent terminals: an in vitro single-unit study in rats

1997 • 170 citations

Unnatural Growth Hormone-Releasing Peptide Begets Natural Ghrelin

2001 • 164 citations

Transgenic approach to the study of body weight regulation.

2000 • 158 citations

Growth Hormone Secretagogues: Physiological Role and Clinical Utility

1999 • 150 citations

Opioid receptor involvement in the effect of AgRP- (83–132) on food intake and food selection

2001 • 144 citations

Human neutrophils facilitate tumor cell transendothelial migration

2001 • 135 citations

Attenuation of leptin-mediated effects by monosodium glutamate-induced arcuate nucleus damage

1997 • 134 citations

Biologic Activities of Growth Hormone Secretagogues in Humans

2001 • 133 citations

Arcuate NPY neurons and energy homeostasis in diet-induced obese and resistant rats

1999 • 132 citations

Long-term CCK-leptin synergy suggests a role for CCK in the regulation of body weight

1999 • 131 citations

Satiating Effect of Cholecystokinina

1994 • 131 citations

Modulation of pulsatile GH release through a novel receptor in hypothalamus and pituitary gland.

1996 • 120 citations

Brain Peptides and Obesity: Pharmacologic Treatment

1995 • 119 citations

Intracerebroventricular growth-hormone-releasing peptide-6 stimulates eating without affecting plasma growth hormone responses in rats

1995 • 114 citations

Growth hormone-releasing peptide and its analogues

1995 • 113 citations

Influence of metabolic substrates and obesity on growth hormone secretion

1995 • 99 citations

Ghrelin: a step forward in the understanding of somatotroph cell function and growth regulation

2000 • 95 citations

Novel hexarelin analogs stimulate feeding in the rat through a mechanism not involving growth hormone release

1998 • 93 citations

Intracerebroventricular administration of the growth hormone-releasing peptide KP-102 increases food intake in free-feeding rats.

1996 • 93 citations

Central Nervous System IL-1β System and Neuropeptide Y mRNAs During IL-1β-induced Anorexia in Rats

1997 • 91 citations

MK-677, an Orally Active Growth Hormone Secretagogue, Reverses Diet-Induced Catabolism1

1998 • 91 citations

Interleukin-1 increases activity of the gastric vagal afferent nerve partly via stimulation of type A CCK receptor in anesthetized rats

1997 • 85 citations

Signal transduction systems employed by synthetic GH-releasing peptides in somatotrophs

1996 • 84 citations

Modest Overexpression of Neuropeptide Y in the Brain Leads to Obesity After High-Sucrose Feeding

2001 • 73 citations

Adenosine Is an Agonist of the Growth Hormone Secretagogue Receptor

2000 • 69 citations

The arcuate nucleus is pivotal in mediating the anorectic effects of centrally administered leptin

1999 • 68 citations

Growth Hormone Inhibits Its Own Secretion by Acting on the Hypothalamus through Its Receptors on Neuropeptide Y Neurons in the Arcuate Nucleus and Somatostatin Neurons in the Periventricular Nucleus

1998 • 66 citations

Motilin: A novel growth hormone releasing agent

1984 • 65 citations

Adenosine: A Partial Agonist of the Growth Hormone Secretagogue Receptor

2000 • 64 citations

Cytokines and sickness behavior: implications from knockout animal models

2001 • 60 citations

Cholecystokinin octapeptide analogues suppress food intake via central CCK-A receptors in mice

1993 • 59 citations

Pharmacological characterisation of a new oral GH secretagogue, NN703

1999 • 59 citations

Effect of β-adrenoceptor activation on [Ca²⁺]_iregulation in murine skeletal myotubes

1999 • 56 citations

Differential Orexigenic Effects of Hexarelin and Its Analogs in the Rat Hypothalamus: Indication for Multiple Growth Hormone Secretagogue Receptor Subtypes

2000 • 53 citations

Secretagogues and the somatotrope: signaling and proliferation.

2000 • 53 citations

Endocrine and Non-Endocrine Activities of Growth Hormone Secretagogues in Humans

1999 • 52 citations

Development of a High Specific Activity Sulfur-35-Labeled Sulfonamide Radioligand That Allowed the Identification of a New Growth Hormone Secretagogue Receptor

1996 • 50 citations

The growth hormone-releasing peptide KP-102 induces c-fos expression in the arcuate nucleus

1996 • 40 citations

Transgenic study of energy homeostasis equation: implications and confounding influences

2000 • 38 citations

Identification of Motilin mRNA in the Brain of Man and Rabbit. Conservation of Polymorphism of the Motilin Gene Across Species

1997 • 33 citations

Growth hormone and insulin-like growth factor-I as anabolic agents

1998 • 31 citations

Peripheral bombesin induces gastric vagal afferent activation in rats

1996 • 25 citations

Demonstration of a functional motilin receptor in TE671 cells from human cerebellum

2001 • 24 citations

Obesity: Progress through genetic manipulation

1998 • 5 citations