Obesity: Progress through genetic manipulation

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

1997 • 2,992 citations

Development of obesity in transgenic mice after genetic ablation of brown adipose tissue

1993 • 1,057 citations

Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y

1996 • 1,020 citations

Attenuation of the Obesity Syndrome of ob/ob Mice by the Loss of Neuropeptide Y

1996 • 814 citations

Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic

1995 • 714 citations

Handbook of obesity

1997 • 629 citations

Genetically lean mice result from targeted disruption of the RIIβ subunit of protein kinase A

1996 • 406 citations

Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity

1997 • 310 citations

Hypogonadism and obesity in mice with a targeted deletion of the Nhlh2 gene

1997 • 160 citations

Reduction of dietary obesity in aP2-Ucp transgenic mice: physiology and adipose tissue distribution

1996 • 132 citations

Transgenic Mice Overexpressing the β1-Adrenergic Receptor in Adipose Tissue Are Resistant to Obesity

1997 • 111 citations

A new class of obesity genes encodes leukocyte adhesion receptors

1997 • 103 citations

High level overexpression of glucose transporter-4 driven by an adipose-specific promoter is maintained in transgenic mice on a high fat diet, but does not prevent impaired glucose tolerance.

1995 • 51 citations

Appetite regulation: Shedding new light on obesity

1996 • 9 citations