The Leptin Receptor

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

1996 • 6,254 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

1995 • 3,730 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

Role of leptin in the neuroendocrine response to fasting

1996 • 3,106 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

The insulin signaling system.

1994 • 1,733 citations

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

1996 • 1,648 citations

Dimerization of cell surface receptors in signal transduction

1995 • 1,631 citations

Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action

1995 • 1,630 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Essential role of Stat6 in IL-4 signalling

1996 • 1,563 citations

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

1996 • 1,560 citations

The role of neuropeptide Y in the antiobesity action of the obese gene product

1995 • 1,521 citations

Identification of targets of leptin action in rat hypothalamus.

1996 • 1,502 citations

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

1989 • 1,411 citations

Cytokine signal transduction

1994 • 1,358 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

1978 • 1,274 citations

Leptin enters the brain by a saturable system independent of insulin

1996 • 1,210 citations

Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance

1996 • 1,170 citations

Transient increase in obese gene expression after food intake or insulin administration

1995 • 1,102 citations

Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice

1996 • 1,097 citations

Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor

1996 • 1,074 citations

OBESE, A NEW MUTATION IN THE HOUSE MOUSE*

1950 • 1,020 citations

Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans

1996 • 1,004 citations

Diabetes, a New Mutation in the Mouse

1966 • 966 citations

Localization of leptin receptor mRNA and the long form splice variant (Ob‐Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization

1996 • 879 citations

Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters.

1996 • 864 citations

The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors.

1996 • 820 citations

Defective STAT signaling by the leptin receptor in diabetic mice.

1996 • 803 citations

Effects of parabiosis of obese with diabetes and normal mice

1973 • 728 citations

Overexpression of the obese (ob) gene in adipose tissue of human obese subjects

1995 • 716 citations

Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction

1996 • 629 citations

Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130.

1991 • 587 citations

Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity.

1995 • 573 citations

Increased obese mRNA expression in omental fat cells from massively obese humans

1995 • 527 citations

Regulation of Expression of ob mRNA and Protein by Glucocorticoids and cAMP

1996 • 497 citations

Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus.

1995 • 466 citations

Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity.

1995 • 367 citations

Leptin Receptor (OB-R) Signaling

1997 • 290 citations

Phenotype of fatty Due to Gln269Pro Mutation in the Leptin Receptor (Lepr)

1996 • 289 citations

Threading analysis suggests that the obese gene product may be a helical cytokine

1995 • 261 citations

Identification of Incidental Sequence Polymorphisms and Absence of the db/db Mouse and fa/fa Rat Mutations

1996 • 225 citations

Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, immunoglobulin, and fibronectin domains.

1990 • 213 citations

Indication for Linkage of the Human OB Gene Region With Extreme Obesity

1996 • 171 citations

Absence of Mutations in the Human OB Gene in Obese/Diabetic Subjects

1996 • 165 citations

Obese gene expression: reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity.

1996 • 158 citations

Extreme Obesity May Be Linked to Markers Flanking the Human OB Gene

1996 • 157 citations

Rat obesity gene fatty (fa) maps to chromosome 5: evidence for homology with the mouse gene diabetes (db).

1991 • 136 citations

OB protein binds specifically to the choroid plexus of mice and rats.

1996 • 124 citations

Human Obese Gene: Molecular Screening in Japanese and Asian Indian NIDDM Patients Associated With Obesity

1996 • 51 citations