Endocrine and Non-Endocrine Activities of Growth Hormone Secretagogues in Humans

The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis*

1986 • 2,235 citations

A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release

1996 • 2,048 citations

Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues

1997 • 1,137 citations

Peptidomimetic Regulation of Growth Hormone Secretion

1997 • 520 citations

Cloning and Characterization of Two Human G Protein-Coupled Receptor Genes (GPR38 and GPR39) Related to the Growth Hormone Secretagogue and Neurotensin Receptors

1997 • 289 citations

Induction of c-fos Messenger Ribonucleic Acid in Neuropeptide Y and Growth Hormone (GH)-Releasing Factor Neurons in the Rat Arcuate Nucleus Following Systemic Injection of the GH Secretagogue, GH-Releasing Peptide-6*

1997 • 285 citations

Corticotropin-Releasing Hormone in Humans*

1992 • 283 citations

Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects.

1996 • 256 citations

Hypothalamic Growth Hormone Secretagogue-Receptor (GHS-R) Expression Is Regulated by Growth Hormone in the Rat

1997 • 190 citations

Growth Hormone Releasing Peptides

1996 • 188 citations

Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, after intravenous, subcutaneous, intranasal, and oral administration in man.

1994 • 155 citations

Specific receptors for synthetic GH secretagogues in the human brain and pituitary gland

1998 • 148 citations

Growth Hormone-Releasing Peptide-6 Stimulates Sleep, Growth Hormone, ACTH and Cortisol Release in Normal Man

1995 • 116 citations

Intracerebroventricular growth-hormone-releasing peptide-6 stimulates eating without affecting plasma growth hormone responses in rats

1995 • 114 citations

Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects

1996 • 109 citations

Activation of the Hypothalamo-Pituitary-Adrenal Axis by the Growth Hormone (GH) Secretagogue, GH-Releasing Peptide-6, in Rats

1997 • 104 citations

Mediation by the central nervous system is critical to the in vivo activity of the GH secretagogue L-692,585

1996 • 101 citations

Growth Hormone (GH)-Releasing Peptide-6 Requires Endogenous Hypothalamic GH-Releasing Hormone for Maximal GH Stimulation¹

1998 • 98 citations

Expression of the Growth Hormone Secretagogue Receptor in Pituitary Adenomas and Other Neuroendocrine Tumors¹

1998 • 94 citations

Induction of c-fos Messenger Ribonucleic Acid in Neuropeptide Y and Growth Hormone (GH)-Releasing Factor Neurons in the Rat Arcuate Nucleus Following Systemic Injection of the GH Secretagogue, GH-Releasing Peptide-6

1997 • 93 citations

Acute cardiovascular and hormonal effects of GH and hexarelin, a synthetic GH-releasing peptide, in humans

1999 • 84 citations

Influence of sex, age and adrenergic pathways on the growth hormone response to GHRP-6

1993 • 83 citations

Effect of growth hormone (GH)-releasing hormone (GHRH), atropine, pyridostigmine, or hypoglycemia on GHRP-6-induced GH secretion in man.

1993 • 81 citations

Adrenocorticotropin- and Cortisol-Releasing Effect of Hexarelin, a Synthetic Growth Hormone-Releasing Peptide, in Normal Subjects and Patients with Cushing’s Syndrome¹

1997 • 81 citations

The Growth Hormone Response to Hexarelin in Children: Reproducibility and Effect of Sex Steroids1

1997 • 81 citations

Blocked growth hormone-releasing peptide (GHRP-6)-induced GH secretion and absence of the synergic action of GHRP-6 plus GH-releasing hormone in patients with hypothalamopituitary disconnection: evidence that GHRP- 6 main action is exerted at the hypothalamic level

1995 • 79 citations

Cardiac ischemia and impairment of vascular endothelium function in hearts from GH-deficient rats: Protection by hexarelin

1997 • 78 citations

Protectant Activity of Hexarelin or Growth Hormone Against Postischemic Ventricular Dysfunction in Hearts from Aged Rats

1998 • 74 citations

Growth Hormone (GH)-Releasing Peptide-6 Requires Endogenous Hypothalamic GH-Releasing Hormone for Maximal GH Stimulation

1998 • 70 citations

Atypical Growth Hormone Releasing Peptides

1994 • 70 citations

Modulation of Growth Hormone-Releasing Activity of Hexarelin in Man

1995 • 69 citations

Human Fetal Pituitary Expresses Functional Growth Hormone-Releasing Peptide Receptors¹

1998 • 67 citations

Widespread transcription of the growth hormone-releasing peptide receptor gene in neuroendocrine human tumors

1997 • 65 citations

Growth hormone (GH)-releasing peptide stimulation of GH release from human somatotroph adenoma cells: interaction with GH-releasing hormone, thyrotropin-releasing hormone, and octreotide.

1994 • 64 citations

Cloning and Characterization of a Human and Murine T-Cell Orphan G-Protein-Coupled Receptor Similar to the Growth Hormone Secretagogue and Neurotensin Receptors

1998 • 63 citations

Age-related variations in the neuroendocrine control, more than impaired receptor sensitivity, cause the reduction in the GH-releasing activity of GHRPs in human aging.

1998 • 55 citations

Metabolic modulation of the growth hormone-releasing activity of hexarelin in man

1995 • 53 citations

Hypothalamic Growth Hormone Secretagogue-Receptor (GHS-R) Expression Is Regulated by Growth Hormone in the Rat

1997 • 53 citations

Effects of Dexamethasone and Alprazolam, a Benzodiazepine, on the Stimulatory Effect of Hexarelin, a Synthetic GHRP, on ACTH, Cortisol and GH Secretion in Humans

1998 • 50 citations

The effect of an opiate antagonist on the hormonal changes induced by hexarelin

1995 • 48 citations

The GH, prolactin, ACTH and cortisol responses to Hexarelin, a synthetic hexapeptide, undergo different age-related variations

1997 • 46 citations

Hexarelin, a Synthetic Growth-Hormone Releasing Peptide, Shows No Interaction with Corticotropin-Releasing Hormone and Vasopressin on Adrenocorticotropin and Cortisol Secretion in Humans

1997 • 45 citations

Orally active growth hormone secretagogues: state of the art and clinical perspectives

1998 • 45 citations

Hexarelin, a synthetic growth hormone releasing peptide, stimulates prolactin secretion in acromegalic but not in hyperprolactinaemic patients

1996 • 42 citations

Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, before and during puberty.

1995 • 40 citations

Human Fetal Pituitary Expresses Functional Growth Hormone-Releasing Peptide Receptors

1998 • 40 citations

Effects of Recombinant Human Insulin-Like Growth Factor I Administration on Growth Hormone (GH) Secretion, Both Spontaneous and Stimulated by GH-Releasing Hormone or Hexarelin, a Peptidyl GH Secretagogue, in Humans1

1999 • 40 citations

Interaction of the growth hormone releasing peptide hexarelin with somatostatin

1997 • 39 citations

Preserved Growth Hormone (GH) Secretion in Aged and Very Old Subjects after Testing with the Combined Stimulus GH-Releasing Hormone plus GH-Releasing Hexapeptide-6¹

1998 • 38 citations

Adrenocorticotropin and Cortisol Hyperresponsiveness to Hexarelin in Patients with Cushing’s Disease Bearing a Pituitary Microadenoma, But Not in Those with Macroadenoma¹

1998 • 35 citations

Mechanisms underlying the negative growth hormone (GH) autofeedback on the GH-releasing effect of hexarelin in man

1997 • 35 citations

The Growth Hormone Response to Hexarelin in Children: Reproducibility and Effect of Sex Steroids

1997 • 35 citations

Identification of a Pituitary Growth Hormone-Releasing Peptide (GHRP) Receptor Subtype by Photoaffinity Labeling

1998 • 35 citations

Oestrogen replacement does not restore the reduced GH-releasing activity of Hexarelin, a synthetic hexapeptide, in post-menopausal women

1997 • 35 citations

Age‐related growth hormone‐releasing activity of growth hormone secretagogues in humans

1997 • 31 citations

Hexarelin induced growth hormone release is influenced by exogenous growth hormone

1995 • 29 citations

Hexarelin exhibits protective activity against cardiac ischaemia in hearts from growth hormone-deficient rats

1998 • 24 citations

Growth hormone secretagogues as corticotrophin-releasing factors

1998 • 20 citations

Influence of beta-adrenergic agonists and antagonists on the GH-releasing effect of Hexarelin in man

1996 • 19 citations

Effects of histaminergic antagonists on the GH-releasing activity of GHRH or hexarelin, a synthetic hexapeptide, in man

1997 • 17 citations

Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, before and during puberty

1995 • 15 citations

Influence of galanin and serotonin on the endocrine response to Hexarelin, a synthetic peptidyl GH-secretagogue, in normal women

1998 • 12 citations

The GH-Releasing Effect of Hexarelin, a Synthetic Hexapeptide, in Newborns is Lower than in Young Adults

1997 • 9 citations