Toward a new neurobiology of energy balance, appetite, and obesity: The anatomists weigh in

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity

1998 • 3,711 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Role of leptin in the neuroendocrine response to fasting

1996 • 3,106 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

Hypothalamic Integration: Organization of the Paraventricular and Supraoptic Nuclei

1983 • 1,962 citations

Brain Maps: Structure of the Rat Brain

1992 • 1,873 citations

Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein

1997 • 1,835 citations

Brain maps: structure of the rat brain

1993 • 1,678 citations

Identification of targets of leptin action in rat hypothalamus.

1996 • 1,502 citations

A role for melanin-concentrating hormone in the central regulation of feeding behaviour

1996 • 1,301 citations

Adipogenesis and Obesity: Rounding Out the Big Picture

1996 • 1,268 citations

Leptin enters the brain by a saturable system independent of insulin

1996 • 1,210 citations

Signals That Regulate Food Intake and Energy Homeostasis

1998 • 1,190 citations

Hypothalamic control of food intake in rats and cats.

1951 • 1,187 citations

The taste reactivity test. I. Mimetic responses to gustatory stimuli in neurologically normal rats

1978 • 1,170 citations

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.

1994 • 1,059 citations

The melanin‐concentrating hormone system of the rat brain: An immuno‐ and hybridization histochemical characterization

1992 • 1,052 citations

Distributions of leptin receptor mRNA isoforms in the rat brain

1998 • 1,011 citations

Leptin: The Tale of an Obesity Gene

1996 • 987 citations

Hypothalamic lesions and adiposity in the rat

1940 • 965 citations

The lateral hypothalamic syndrome: Recovery of feeding and drinking after lateral hypothalamic lesions.

1962 • 880 citations

Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area

1998 • 817 citations

Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues

1997 • 771 citations

Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus

1998 • 753 citations

Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus

1997 • 731 citations

Organization of cerebral cortical afferent systems in the rat. II. Magnocellular basal nucleus

1984 • 707 citations

Hypocretin/Orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: Relationship to the neuropeptide Y and agouti gene-related protein systems

1998 • 687 citations

The organization of forebrain afferents to the paraventricular and supraoptic nuclei of the rat

1983 • 681 citations

Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice.

1997 • 670 citations

The physiology of motivation.

1954 • 663 citations

Colocalization of neuropeptide Y immunoreactivity in brainstem catecholaminergic neurons that project to the paraventricular nucleus of the hypothalamus

1985 • 661 citations

Nigrostriatal bundle damage and the lateral hypothalamic syndrome.

1974 • 632 citations

Characterization of melanin-concentrating hormone in chum salmon pituitaries

1983 • 583 citations

The taste reactivity test. II. Mimetic responses to gustatory stimuli in chronic thalamic and chronic decerebrate rats

1978 • 582 citations

An arcuato-paraventricular and -dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenaline in the rat

1985 • 523 citations

Coexpression of Leptin Receptor and Preproneuropeptide Y mRNA in Arcuate Nucleus of Mouse Hypothalamus

1996 • 473 citations

Afferent projections to the oral motor nuclei in the rat

1983 • 463 citations

Leptin Inhibition of the Hypothalamic-Pituitary-Adrenal Axis in Response to Stress¹

1997 • 460 citations

Leptin Activates Neurons in Ventrobasal Hypothalamus and Brainstem

1997 • 428 citations

Melanin-Concentrating Hormone Acutely Stimulates Feeding, But Chronic Administration Has No Effect on Body Weight

1997 • 416 citations

The hypothalamus, intrinsic connections and outflow pathways to the endocrine system in relation to the control of feeding and metabolism

1987 • 394 citations

Reexamination of the role of the hypothalamus in motivation.

1970 • 388 citations

Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei

1998 • 376 citations

The physiological psychology of hunger: A physiological perspective.

1976 • 324 citations

Organization of cerebral cortical afferent systems in the rat. II. Hypothalamocortical projections

1985 • 316 citations

Hypothalamic Obesity: The Myth of the Ventromedial Nucleus

1973 • 291 citations

The Rat Melanin-Concentrating Hormone Messenger Ribonucleic Acid Encodes Multiple Putative Neuropeptides Coexpressed in the Dorsolateral Hypothalamus*

1989 • 289 citations

Immunohistochemical localization of a melanin concentrating hormone-like peptide in the rat brain

1985 • 267 citations

Reciprocal parabrachial-cortical connections in the rat

1982 • 250 citations

Neural mechanisms for the functional coupling of autonomic, endocrine and somatomotor responses in adaptive behavior

1981 • 241 citations

Arcuate nucleus neurons that project to the hypothalamic paraventricular nucleus: Neuropeptidergic identity and consequences of adrenalectomy on mRNA levels in the rat

1995 • 197 citations

Effects of Leptin on Corticotropin-Releasing Factor (CRF) Synthesis and CRF Neuron Activation in the Paraventricular Hypothalamic Nucleus of Obese (ob/ob) Mice

1998 • 164 citations

The distribution and cells of origin of ACTH(1–39)-stained varicosities in the paraventricular and supraoptic nuclei

1982 • 144 citations

Melanin-concentrating hormone is a potent anorectic peptide regulated by food-deprivation and glucopenia in the rat

1996 • 143 citations

Arcuate Nucleus Ablation Prevents Fasting-Induced Suppression of ProTRH mRNA in the Hypothalamic Paraventricular Nucleus

1998 • 138 citations

A diffuse αMSH‐immunoreactive projection to the hippocampus and spinal cord from individual neurons in the lateral hypothalamic area and zona incerta

1984 • 137 citations

Forebrain origins and terminations of the medial forebrain bundle metabolically activated by rewarding stimulation or by reward-blocking doses of pimozide

1985 • 122 citations

Intrahypothalamic injections of kainic acid produce feeding and drinking deficits in rats

1978 • 108 citations

Glucoregulatory Feeding by Rats After Intraventricular 6-Hydroxydopamine or Lateral Hypothalamic Lesions

1975 • 107 citations

C 16: Is Interruption of the Nigro-Striatal Dopamine System Producing the “Lateral Hypothalamus Syndrome”?

1970 • 92 citations

Lateral hypothalamic innervation of the cerebral cortex: Immunoreactive staining for a peptide resembling but immunochemically distinct from pituitary/arcuate α-melanocyte stimulating hormone

1986 • 91 citations

Evidence for vagal involvement in the eating elicited by adrenergic stimulation of the paraventricular nucleus

1981 • 72 citations

The physiology of motivation.

1994 • 41 citations