Chemotherapy for brain metastases: Recent developments and clinical considerations

Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas

1978 • 1,663 citations

Determinants of tumor blood flow: a review.

1988 • 1,362 citations

Therapeutic irradiation and brain injury

1980 • 985 citations

Radiation‐induced dementia in patients cured of brain metastases

1989 • 943 citations

Delivery of Novel Therapeutic Agents in Tumors: Physiological Barriers and Strategies

1989 • 571 citations

Radation therapy for brain metastases

1980 • 461 citations

Cerebral necrosis after radiotherapy and/or intraarterial chemotherapy for brain tumors: PET and neuropathologic studies

1988 • 420 citations

Comparisons of carmustine, procarbazine, and high-dose methylprednisolone as additions to surgery and radiotherapy for the treatment of malignant glioma.

1983 • 394 citations

Adriamycin chemotherapy—efficacy, safety, and pharmacologic basis of an intermittent single high-dosage schedule

1974 • 393 citations

The Concept of a Blood-Brain Barrier

1980 • 347 citations

Brain metastases in adenocarcinoma of the lung: frequency, risk groups, and prognosis.

1988 • 322 citations

Analysis of the fate of systemically administered liposomes and implications for their use in drug delivery.

1982 • 303 citations

Chemotherapy induces regression of brain metastases in breast carcinoma

1986 • 271 citations

Breast cancer: metastatic patterns and their prognosis.

1988 • 256 citations

Neoadjuvant chemotherapy for newly diagnosed germ-cell tumors of the central nervous system

1987 • 216 citations

Liposomes in biological systems

1981 • 216 citations

Identification of an optimal subgroup for treatment evaluation of patients with brain metastases using rtog study 7916

1989 • 211 citations

Breast Cancer

1988 • 207 citations

Glucocorticoid treatment for brain metastases and epidural spinal cord compression: a review.

1988 • 204 citations

Criteria for evaluating patients undergoing chemotherapy for malignant brain tumors

1977 • 201 citations

Liposomes in biological systems

1980 • 193 citations

Variable Content of Histaminase, L-Dopa Decarboxylase and Calcitonin in Small-Cell Carcinoma of the Lung

1978 • 176 citations

Site-Specific, Sustained Release of Drugs to the Brain

1981 • 176 citations

Single brain metastases: surgery plus radiation or radiationalone

1986 • 173 citations

Toxicity of Chemotherapy.

1985 • 170 citations

Therapeutic Efficacy of Multiagent Chemotherapy with Drug Delivery Enhancement by Blood-Brain Barrier Modification in Glioblastoma

1986 • 166 citations

The morphology of cerebrospinal fluid drainage pathways in human arachnoid granulations

1985 • 161 citations

The treatment of single brain metastasis from non-oat cell lung: Carcinoma surgery and radiation. Versus radiation therapy alone

1986 • 152 citations

Increased detection of intracranial metastases with intravenous Gd-DTPA.

1987 • 149 citations

Oncology of the Nervous System

1983 • 146 citations

Cancer and the Nervous System

2012 • 142 citations

Malignant melanoma brain metastases. Review of roswell park memorial institute experience

1984 • 138 citations

Intracarotid infusion of cis-diamminedichloroplatinum in the treatment of recurrent malignant brain tumors

1984 • 136 citations

Cancer and the Nervous System

1969 • 130 citations

Optimizing drug delivery to brain tumors

1987 • 118 citations

Palliative radiotherapy for metastatic malignant melanoma: Brain metastases, bone metastases, and spinal cord compression

1988 • 114 citations

The Management of Brain Metastases

1983 • 108 citations

The rationale and methodology for intra-arterial chemotherapy with BCNU as treatment for glioblastoma

1985 • 106 citations

The optimum schedule for palliative radiotherapy for metastatic brain cancer

1977 • 102 citations

Intraparenchymal brain metastases: MR imaging versus contrast-enhanced CT.

1988 • 102 citations

Stem-cell survival and tumor control in the Lewis lung carcinoma.

1975 • 100 citations

Chemotherapy of Primary Brain Tumors

1985 • 99 citations

Chemotherapy of brain tumors: physiological and pharmacokinetic considerations.

1986 • 97 citations

Staging and prognostic factors in small cell carcinoma of the lung.

1983 • 89 citations

Neurologic disorders in patients with small cell lung cancer

1987 • 89 citations

The blood-brain barrier in health and disease

1987 • 87 citations

Chemotherapy of brain metastases: Current status

1984 • 84 citations

Regional Blood Flow and Blood-to-Tissue Transport in Five Brain Tumor Models

2015 • 78 citations

Drug Delivery to the Brain by Blood-Brain Barrier Circumvention and Drug Modification

1989 • 76 citations

Brain metastases in breast cancer patients receiving adjuvant chemotherapy

1982 • 74 citations

Cerebral metastatic choriocarcinoma: intensive therapy and prognosis.

1980 • 74 citations

Radioimmunotherapy of cancer: clinical studies and limiting factors

1987 • 73 citations

Redox Delivery System for Brain-Specific, Sustained Release of Dopamine

1983 • 71 citations

The Effect of Steroids on the Extravascular Distribution of Radiographic Contrast Material and Technetium Pertechnetate in Brain Tumors as Determined by Computed Tomography

1976 • 68 citations

Favorable Prognosis of Brain Metastases in Small Cell Lung Cancer

1987 • 68 citations

Concentrations of vinblastine in human intracerebral tumor and other tissues

1983 • 63 citations

Central neurotoxicity following intracarotid BCNU chemotherapy for malignant gliomas

1986 • 63 citations

Potential central nervous system antitumor agents. Hydantoin derivatives

1975 • 63 citations

AN ASSESSMENT OF THE ACCURACY OF COMPUTERIZED TRANSVERSE AXIAL SCANNING (EMI SCANNER) IN THE DIAGNOSIS OF INTRACRANIAL TUMOUR

1975 • 63 citations

Brain metastases from small cell lung cancer treated with combination chemotherapy

1988 • 55 citations

Intracarotid Chemotherapy with a Combination of 1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU), cis-Diaminedichloroplatinum (Cisplatin), and 4′-O-Demethyl-1-O-(4,6-O-2-thenylidene-β-D-glucopyranosyl)epipodophyllotoxin (VM-26) in the Treatment of Primary and Metastatic Brain Tumors

1984 • 55 citations

Chemotherapy administered in conjunction with osmotic blood-brain barrier modification in patients with brain metastases

1987 • 49 citations

Rapid efflux of some quaternary ammonium compounds from cerebrospinal fluid

1962 • 48 citations

Regional blood flow, capillary permeability, and glucose utilization in two brain tumor models: preliminary observations and pharmacokinetic implications.

1981 • 47 citations

Intracerebral penetration and tissue distribution of 2,5-diaziridinyl 3,6-bis(carboethoxyamino) 1,4-benzoquinone (AZQ, NSC-182986)

1983 • 47 citations

Chemotherapy of brain tumors

1972 • 43 citations

Chemotherapy in the treatment of malignant brain tumors.

1975 • 43 citations

Penetration of teniposide (VM-26) into human intracerebral tumors

1984 • 41 citations

Anxiolytic activity of a brain delivery system for GABA

1987 • 41 citations

BILATERAL BONE‐MARROW EXAMINATIONS IN SMALL‐CELL ANAPLASTIC CARCINOMA OF THE LUNG

1979 • 40 citations

Systemic Combination Chemotherapy as Primary Treatment of Brain Metastasis From Lung Cancer

1984 • 37 citations

Uptake and Distribution of <sup>3</sup>H-Methotrexate by the Murine Ependymoblastoma

1972 • 37 citations

Tissue and Hepatic Subcellular Distribution of Liposomes Containing Bleomycin after Intravenous Administration to Patients with Neoplasms

1976 • 33 citations

Long-term survival after brain metastasis from lung cancer

1986 • 33 citations

Ability of a New Antitumor Agent, AZQ, to Penetrate into Cerebrospinal Fluid

1981 • 27 citations

Teniposide (VM26): An effective treatment for brain metastases of small cell carcinoma of the lung

1988 • 26 citations

Therapeutic Potential for Blood-Brain Barrier Modification in Malignant Brain Tumor

2015 • 25 citations

Chemotherapy of experimental metastatic brain tumors in female Wistar rats.

1979 • 25 citations

Drug delivery to CNS tumors.

1981 • 23 citations

The Pharmacology of Brain Tumour Chemotherapy

1986 • 19 citations

Erfolgreiche Behandlung von Hirnmetastasen bei Mamma-Karzinom mit nicht liquorgängigen Zytostatika und Hormonen

1983 • 18 citations

Phase II evaluation of diaziquone (CI-904, AZQ) in the treatment of human malignant glioma

1985 • 17 citations

Keynote address: Chemical manipulations of tissue oxygenation for therapeutic benefit

1989 • 17 citations

Malignant Brain Tumors in Children

1987 • 17 citations

Principles of Chemotherapy in Brain Neoplasia

1987 • 17 citations

Intra-arterial chemotherapy of malignant gliomas.

1988 • 17 citations

Pathologic Effects of Chemotherapy

1983 • 16 citations

False-Negative Computerized Tomography in Brain Tumor

1977 • 16 citations

Phase II study of aziridinylbenzoquinone (AZQ) in patients with central nervous system malignancies: a Southwest Oncology Group study

1985 • 15 citations

Therapy of malignant brain tumors

1987 • 15 citations

Effect of 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride on experimental brain tumors.

1979 • 12 citations

Enhancing mass on CT

1983 • 12 citations

Uptake and distribution of 3h-methotrexate by the murine ependymo- blastoma.

1972 • 11 citations

Application of radioimmunoassay to monitor treatment of human cerebral gliomas with bleomycin entrapped within liposomes.

1988 • 11 citations

Transient neurologic disturbances, brain tumors, and normal computed tomography scans

1983 • 11 citations

Stimulation of gluconeogenesis by propylene glycol in the fasting rat

1974 • 11 citations

Corticosteroids:Their Effect on Primary and Metastatic Brain Tumors

1983 • 10 citations

Cerebral metastases from choriocarcinoma

1987 • 8 citations

Carrier drugs

1988 • 8 citations

Radiation induced soft tissue sarcoma and bone sarcoma

1977 • 8 citations

Simultaneous radiotherapy and chemotherapy in the treatment of brain metastases of malignant solid tumours.

1987 • 7 citations

Chemotherapy for Brain Metastases

2015 • 6 citations

Chemotherapy for primary brain tumors.

1978 • 5 citations

Biological approaches to the controlled delivery of drugs

1991 • 5 citations

A Molded Acrylic Applicator for Guiding the Peroral X-Ray Beam

1976 • 4 citations

False-negative computerized tomography in brain tumor

1977 • 4 citations

[Surgical treatment of brain metastases].

1984 • 4 citations